公开(公告)号：US20130119242A1

公开(公告)日：2013-05-16

申请号：US13509502

申请日：2010-11-10

申请人： Nicholas John Goddard ,  Paul Taylor

发明人： Nicholas John Goddard ,  Paul Taylor

IPC分类号： G01N21/17

CPC分类号： G01N21/17 ,  G01N21/553 ,  G01N21/7703 ,  G01N33/54373 ,  G01N2021/7776 ,  G01N2333/922 ,  G01N2600/00

摘要： An optical sensor comprising a waveguide having a sensing layer which is molecularly imprinted such that it will receive and retain target entities to be sensed, the optical sensor further comprising a detection apparatus arranged to detect a change of an optical property of the waveguide which occurs when the target entities are received and retained in the sensing layer.

摘要翻译： 一种光学传感器，包括具有感测层的波导，该感测层被分子印迹，使得其将接收并保持待感测的目标实体，所述光学传感器还包括检测装置，该检测装置被布置成检测波导的光学特性的变化， 目标实体被接收并保留在感测层中。

公开(公告)号：US09316579B2

公开(公告)日：2016-04-19

申请号：US13509502

申请日：2010-11-10

申请人： Nicholas John Goddard ,  Paul Taylor

发明人： Nicholas John Goddard ,  Paul Taylor

IPC分类号： G01D5/353 ,  G02B6/43 ,  G01N21/17 ,  G01N21/552 ,  G01N21/77 ,  G01N33/543

CPC分类号： G01N21/17 ,  G01N21/553 ,  G01N21/7703 ,  G01N33/54373 ,  G01N2021/7776 ,  G01N2333/922 ,  G01N2600/00

摘要： An optical sensor comprising a waveguide having a sensing layer which is molecularly imprinted such that it will receive and retain target entities to be sensed, the optical sensor further comprising a detection apparatus arranged to detect a change of an optical property of the waveguide which occurs when the target entities are received and retained in the sensing layer.

摘要翻译： 一种光学传感器，包括具有感测层的波导，该感测层被分子印迹，使得其将接收并保持待感测的目标实体，所述光学传感器还包括检测装置，其被设置为检测波导的光学特性的变化， 目标实体被接收并保留在感测层中。

公开(公告)号：US06509161B1

公开(公告)日：2003-01-21

申请号：US09514994

申请日：2000-02-29

申请人： Michael Gordon Barker ,  Nicholas Billinton ,  Nicholas John Goddard ,  Richard Maurice Walmsley ,  Andrew William Knight ,  Peter Robert Fielden

发明人： Michael Gordon Barker ,  Nicholas Billinton ,  Nicholas John Goddard ,  Richard Maurice Walmsley ,  Andrew William Knight ,  Peter Robert Fielden

IPC分类号： G01N3353

CPC分类号： G01N33/582

摘要： A method of distinguishing between fluorescent light emitted by green fluorescent protein and fluorescent light emitted by auto-fluorescent molecules, the method comprising: using plane-polarised light to illuminate a sample containing green fluorescent protein and auto-fluorescent molecules; detecting the intensity of fluorescent light that is emitted with a first polarisation from the sample; detecting the intensity of fluorescent light that is emitted with a second polarisation from the sample; and subtracting a first of said detected intensities from a second of said detected intensities to obtain a difference signal.

摘要翻译： 一种鉴别绿色荧光蛋白发出的荧光和由自身荧光分子发出的荧光的方法，其特征在于，使用平面偏振光照射含有绿色荧光蛋白和自身荧光分子的样品，检测荧光强度 用来自样品的第一极化发射的光;检测来自样品的以第二极化发射的荧光的强度; 并且从所述检测到的强度的第二个中减去所述检测到的强度中的第一个，以获得差分信号。

公开(公告)号：US07492978B2

公开(公告)日：2009-02-17

申请号：US10529970

申请日：2002-10-07

申请人： Mohammed Zourob ,  Stephan Mohr ,  Bernard James Treves Brown ,  Peter Robert Fielden ,  Nicholas John Goddard

发明人： Mohammed Zourob ,  Stephan Mohr ,  Bernard James Treves Brown ,  Peter Robert Fielden ,  Nicholas John Goddard

IPC分类号： G02B6/00 ,  G02B6/26

CPC分类号： G01N21/648 ,  G01N21/47 ,  G01N21/7703 ,  G01N2015/0088 ,  G01N2015/1447 ,  G01N2021/7723 ,  G01N2021/7776 ,  G02B6/122 ,  G02B2006/12138

摘要： A novel single point leaky waveguide structure and its use as an optical sensor for the detection of particles is disclosed. The waveguide structure is fabricated to increase the overlap of the evanescent field extension from the sensor surface with particles in the bulk solution of a flowing system so as to place most of the volume of the particles within the evanescent field. Increasing the overlap of the evanescent field with the particles and permitting mode propagation along the direction of flow for a few millimetres provides an effective interrogation approach for multiple particle detection in a single flow channel.

摘要翻译： 公开了一种新颖的单点泄漏波导结构及其作为用于检测颗粒的光学传感器的用途。 制造波导结构以增加从传感器表面的消逝场延伸与流动系统的本体溶液中的颗粒的重叠，从而将大部分体积的颗粒置于消逝场内。 增加ev逝场与颗粒的重叠，并允许模式沿流动方向传播几毫米，为单个流道中的多个粒子检测提供了有效的询问方法。

公开(公告)号：US06483959B1

公开(公告)日：2002-11-19

申请号：US09622698

申请日：2000-10-19

申请人： Kirat Singh ,  Nicholas John Goddard

发明人： Kirat Singh ,  Nicholas John Goddard

IPC分类号： G02B600

CPC分类号： G01N21/7703 ,  G01N21/0303 ,  G01N21/553

摘要： A waveguide structure comprising a medium disposed of a sensing layer (21), a second layer of material (22) having a refractive index greater than that of the medium, and a substrate (24). The structure defines a waveguide capable of supporting an optical mode confined in a sensing layer. The medium is adapted for performing chemical or biological reactions within the medium which will result in a change of an optical property of the sensing layer of the waveguide. The thickness and refractive indexes of the layers are chosen such that an optical mode confined in the sensing layer will suffer substantially anti-resonant reflection as a consequence of the interface between the sensing layer and the second layer and the interface between the second layer and the substrate. Alternatively, the waveguide may comprise a low index sensing medium held between a superstrate and a substrate each of which has a refractive index higher than that of the medium. The waveguide may be capable of supporting two modes, such that one of the modes may be used as a reference during measurement of optical properties of a medium. The waveguide may be capable of supporting a leaky waveguide mode, the presence of the leaky waveguide mode being indicated by a peak of light returned from the waveguide.

摘要翻译： 一种波导结构，包括设置有感测层（21）的介质，具有大于介质折射率的折射率的第二材料层（22）和衬底（24）。 该结构限定了能够支持限定在感测层中的光学模式的波导。 介质适于在介质内进行化学或生物反应，这将导致波导的感测层的光学特性的变化。 选择层的厚度和折射率，使得限制在感测层中的光学模式将由于感测层和第二层之间的界面以及第二层和第二层之间的界面而遭受基本的反谐振反射 基质。 或者，波导可以包括保持在衬底和衬底之间的低折射率感测介质，每个衬底的折射率高于介质的折射率。 波导可能能够支持两种模式，使得在介质的光学性质的测量期间，可以将一种模式用作参考。 波导可能能够支持泄漏波导模式，漏波导模式的存在由波导返回的光的峰值表示。