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1.发明申请NOVEL SPIRO COMPOUNDS USEFUL AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE 有权新型螺旋体化合物作为硬脂酸苄酯的一种抑制剂公开(公告)号：US20110312952A1
公开(公告)日：2011-12-22
申请号：US13148985
申请日：2010-02-16
IPC分类号： A61K31/438 , C07D498/10 , A61P3/06 , C07D417/14 , A61P3/10 , A61K31/537 , C07D491/107
CPC分类号： A61K31/438 , C07D491/107
摘要： Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
摘要翻译： 结构式（I）的杂芳族化合物是相对于其他已知的硬脂酰辅酶A去饱和酶的硬脂酰辅酶Aδ-9去饱和酶（SCD1）的选择性抑制剂。 本发明的化合物可用于预防和治疗与脂质合成和代谢异常有关的病症，包括心血管疾病，如动脉粥样硬化; 肥胖; 糖尿病; 神经系统疾病; 代谢综合征; 胰岛素抵抗; 和肝脂肪变性。
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2.发明授权Spiro compounds useful as inhibitors of stearoyl-coenzyme A delta-9 desaturase 有权可用作硬脂酰辅酶A-9去饱和酶抑制剂的螺环化合物公开(公告)号：US09168248B2
公开(公告)日：2015-10-27
申请号：US13148985
申请日：2010-02-16
IPC分类号： C07D471/00 , C07D491/10 , A61K31/44 , A61K31/438 , C07D491/107
CPC分类号： A61K31/438 , C07D491/107
摘要： Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
摘要翻译： 结构式（I）的杂芳族化合物是相对于其他已知的硬脂酰辅酶A去饱和酶的硬脂酰辅酶Aδ-9去饱和酶（SCD1）的选择性抑制剂。 本发明的化合物可用于预防和治疗与脂质合成和代谢异常有关的病症，包括心血管疾病，如动脉粥样硬化; 肥胖; 糖尿病; 神经系统疾病; 代谢综合征; 胰岛素抵抗; 和肝脂肪变性。
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公开(公告)号：US08383643B2
公开(公告)日：2013-02-26
申请号：US13383446
申请日：2010-07-21
IPC分类号： A61K31/438 , C07D491/107
CPC分类号： C07D491/107
摘要： Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
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4.发明申请NOVEL SPIRO COMPOUNDS USEFUL AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE 失效新型螺旋体化合物作为硬脂酸苄酯的一种抑制剂公开(公告)号：US20120122912A1
公开(公告)日：2012-05-17
申请号：US13383446
申请日：2010-07-21
IPC分类号： A61K31/438 , A61P7/00 , A61P5/48 , A61P3/06 , C07D491/107 , A61P3/10
CPC分类号： C07D491/107
摘要： Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
摘要翻译： 结构式（I）的杂芳族化合物是相对于其他已知的硬脂酰辅酶A去饱和酶的硬脂酰辅酶Aδ-9去饱和酶（SCD1）的选择性抑制剂。 本发明的化合物可用于预防和治疗与脂质合成和代谢异常有关的病症，包括心血管疾病，如动脉粥样硬化; 肥胖; 糖尿病; 神经系统疾病; 代谢综合征; 胰岛素抵抗; 和肝脂肪变性。
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公开(公告)号：US20080132542A1
公开(公告)日：2008-06-05
申请号：US11998501
申请日：2007-11-30
IPC分类号： A61K31/454 , A61P3/06 , A61P3/10 , A61P9/10 , C07D417/14
CPC分类号： C07D413/14 , C07D417/14
摘要： Azacycloalkane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
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6.发明授权Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase 有权氮杂环烷烃衍生物作为硬脂酰辅酶抑制剂，δ-9去饱和酶公开(公告)号：US08063224B2
公开(公告)日：2011-11-22
申请号：US11998501
申请日：2007-11-30
IPC分类号： C07D401/00 , A61K31/445
CPC分类号： C07D413/14 , C07D417/14
摘要： Azacycloalkane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
摘要翻译： 结构式I的Azacycalkalkane衍生物是相对于其它已知的硬脂酰辅酶A去饱和酶的硬脂酰辅酶A delta-9去饱和酶（SCD1）的选择性抑制剂。 本发明的化合物可用于预防和治疗与脂质合成和代谢异常有关的病症，包括心血管疾病，如动脉粥样硬化; 肥胖; 糖尿病; 神经系统疾病; 代谢综合征; 胰岛素抵抗; 和肝脂肪变性。
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7.发明申请NOVEL HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE 审中-公开作为维生素D的抑制剂的新型异构化合物DELTA-9去饱和酶公开(公告)号：US20100249192A1
公开(公告)日：2010-09-30
申请号：US12744062
申请日：2008-12-09
IPC分类号： A61K31/4439 , C07D413/04 , A61K31/422 , A61P3/10 , A61P3/04 , A61P1/16 , A61P3/06 , A61P9/10 , C07D413/14 , C07D403/04 , A61K31/4192 , A61K31/41
CPC分类号： C07D401/04 , C07D403/04 , C07D409/04 , C07D413/04
摘要： Heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; Metabolic Syndrome; insulin resistance; cancer; liver steatosis; and non-alcoholic steatohepatitis. HetAr−W−X−Ar (I)
摘要翻译： 结构式I的杂芳族化合物是硬脂酰辅酶A delta-9去饱和酶（SCD）的抑制剂。 本发明的化合物可用于预防和治疗与脂质合成和代谢异常有关的病症，包括心血管疾病; 动脉粥样硬化 肥胖; 糖尿病; 神经系统疾病; 代谢综合征; 胰岛素抵抗; 癌症; 肝脂肪变性 和非酒精性脂肪性肝炎。 HetAr-W-X-Ar（I）
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8.发明申请BICYCLIC HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE 审中-公开作为硬脂酸苄酯A DELTA-9去饱和酶抑制剂的双相异构化合物公开(公告)号：US20100197692A1
公开(公告)日：2010-08-05
申请号：US12668537
申请日：2008-07-18
IPC分类号： A61K31/4985 , C07D487/04 , A61K31/519 , C07D471/04 , A61P3/10 , A61P3/04 , A61P9/10
CPC分类号： C07D473/32 , C07D487/04 , C07D513/04
摘要： Bicyclic heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; liver steatosis; and non-alcoholic steatohepatitis.
摘要翻译： 结构式I的双环杂芳族化合物是硬脂酰辅酶A-9去饱和酶（SCD）的抑制剂。 本发明的化合物可用于预防和治疗与脂质合成和代谢异常有关的病症，包括心血管疾病; 动脉粥样硬化 肥胖; 糖尿病; 神经系统疾病; 代谢综合征; 胰岛素抵抗; 肝脂肪变性 和非酒精性脂肪性肝炎。
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9.发明申请HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE 审中-公开作为硬脂酸苄酯A DELTA-9去饱和酶抑制剂的异构化合物公开(公告)号：US20110166152A1
公开(公告)日：2011-07-07
申请号：US13119467
申请日：2009-09-30
IPC分类号： A61K31/4985 , C07D277/62 , C07D487/04 , C07D471/04 , A61K31/426 , A61K31/437 , A61P3/10 , A61P9/10
CPC分类号： C07D403/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D487/04 , C07D498/04 , C07D513/04
摘要： Heteroaromatic compounds of structural formula (I) are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis.
摘要翻译： 结构式（I）的杂芳族化合物是硬脂酰辅酶A delta-9去饱和酶（SCD）的抑制剂。 本发明的化合物可用于预防和治疗与脂质合成和代谢异常有关的病症，包括心血管疾病，如动脉粥样硬化; 肥胖; 2型糖尿病; 胰岛素抵抗; 高血糖症 代谢综合征; 神经系统疾病; 癌症; 和肝脂肪变性。
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10.发明申请HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE 审中-公开作为硬脂酸苄酯A DELTA-9去饱和酶抑制剂的异构化合物公开(公告)号：US20110152295A1
公开(公告)日：2011-06-23
申请号：US13060756
申请日：2009-09-02
IPC分类号： A61K31/506 , C07D277/30 , C07D401/14 , C07D257/04 , C07D271/06 , C07D417/14 , C07D261/06 , A61K31/4178 , A61K31/4439 , A61K31/41 , A61K31/4245 , A61K31/422 , A61P9/10
CPC分类号： A61K31/4192 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/506 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14
摘要： Heteroaromatic compounds of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
摘要翻译： 结构式I的杂芳族化合物是相对于其它已知的硬脂酰辅酶A去饱和酶的硬脂酰辅酶Aδ-9去饱和酶（SCD1）的选择性抑制剂。 本发明的化合物可用于预防和治疗与脂质合成和代谢异常有关的病症，包括心血管疾病，如动脉粥样硬化; 肥胖; 糖尿病; 神经系统疾病; 代谢综合征; 胰岛素抵抗; 和肝脂肪变性。
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