-
公开(公告)号：US08481772B2
公开(公告)日：2013-07-09
申请号：US13407346
申请日：2012-02-28
申请人： Nicos A. Petasis
发明人： Nicos A. Petasis
IPC分类号： A23D9/00
CPC分类号： C07C69/732 , C07B2200/05 , C07F7/081 , C07F7/1804 , C07F7/1892
摘要： The invention features methods for the preparation of naturally occurring trihydroxy polyunsaturated eicosanoids and their structural analogs. The invention further provides new derivatives and analogs of trihydroxy polyunsaturated eicosanoids that can be prepared according to these methods. The invention also provides compositions and methods using trihydroxy polyunsaturated eicosanoid derivatives for the prevention, amelioration and treatment of a variety of diseases or conditions associated with inflammation or inflammatory response, autoimmune diseases, rheumatoid arthritis, cardiovascular diseases, or abnormal cell proliferation or cancer.
-
2.发明申请ANTI-INFLAMMATORY ACTIONS OF NEUROPROTECTIN D1/PROTECTIN D1 AND ITS NATURAL STEREOISOMERS 有权神经保护素D1 /保护素D1及其天然立体异构体的抗炎作用公开(公告)号：US20130150446A1
公开(公告)日：2013-06-13
申请号：US13625865
申请日：2012-09-24
IPC分类号： A61K31/202
CPC分类号： A61K31/202 , C07C59/42 , C07C69/732
摘要： The invention describes novel isolated, purified, 10,17-dihydroxy-docoosahexaenoic acids, esters, derivatives and their preparation.
摘要翻译： 本发明描述了新的分离的纯化的10,17-二羟基二十二碳六烯酸，酯，衍生物及其制备方法。
-
公开(公告)号：US07902257B2
公开(公告)日：2011-03-08
申请号：US12469423
申请日：2009-05-20
申请人： Nicos A. Petasis
发明人： Nicos A. Petasis
IPC分类号： A01N37/06
CPC分类号： C07F7/1892 , C07B2200/05 , C07C67/303 , C07F7/081 , C07C69/732
摘要： The invention features methods for the preparation of naturally occurring trihydroxy polyunsaturated eicosanoids and their structural analogs. The invention further provides new derivatives and analogs of trihydroxy polyunsaturated eicosanoids that can be prepared according to these methods. The invention also provides compositions and methods using trihydroxy polyunsaturated eicosanoid derivatives for the prevention, amelioration and treatment of a variety of diseases or conditions associated with inflammation or inflammatory response, autoimmune diseases, rheumatoid arthritis, cardiovascular diseases, or abnormal cell proliferation or cancer.
摘要翻译： 本发明的特征在于制备天然存在的三羟基多不饱和类花生酸及其结构类似物的方法。 本发明还提供了可以根据这些方法制备的三羟基多不饱和类花生酸的新衍生物和类似物。 本发明还提供了使用三羟基多不饱和类花生酸衍生物预防，改善和治疗与炎症或炎症反应，自身免疫性疾病，类风湿性关节炎，心血管疾病或异常细胞增殖或癌症相关的各种疾病或病症的组合物和方法。
-
公开(公告)号：US07812054B2
公开(公告)日：2010-10-12
申请号：US12539728
申请日：2009-08-12
IPC分类号： A01N37/06
CPC分类号： A61K31/202 , A61K31/22 , A61K31/365 , C07B2200/07 , C07C69/732 , C07C69/736 , C07C229/30 , C07C235/28 , C07C259/06 , C07C2601/16 , A61K2300/00
摘要： This invention provides new lipoxin analogs, compositions containing analogs, and methods of using these compounds and compositions for treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease. The invention also provides for methods of treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease with compositions containing COX-2 inhibitors. Further, the invention provides methods for preventing systemic diseases beyond theoral cavity that are related to periodontal disease using the composition containing lipoxin analogs, COX-2 inhibitors, or both.
摘要翻译： 本发明提供了新的脂氧素类似物，含有类似物的组合物，以及使用这些化合物和组合物治疗和预防口腔炎症的方法，包括牙龈炎，牙周炎和其它形式的牙周病。 本发明还提供了含有COX-2抑制剂的组合物治疗和预防口腔炎症的方法，包括牙龈炎，牙周炎和其他形式的牙周病。 此外，本发明提供了使用含有脂氧素类似物，COX-2抑制剂或两者的组合物来预防与牙周疾病相关的全腔外疾病的方法。
-
5.发明申请公开(公告)号：US20090311201A1
公开(公告)日：2009-12-17
申请号：US12539728
申请日：2009-08-12
CPC分类号： A61K31/202 , A61K31/22 , A61K31/365 , C07B2200/07 , C07C69/732 , C07C69/736 , C07C229/30 , C07C235/28 , C07C259/06 , C07C2601/16 , A61K2300/00
摘要： This invention provides new lipoxin analogs, compositions containing analogs, and methods of using these compounds and compositions for treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease. The invention also provides for methods of treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease with compositions containing COX-2 inhibitors. Further, the invention provides methods for preventing systemic diseases beyond theoral cavity that are related to periodontal disease using the composition containing lipoxin analogs, COX-2 inhibitors, or both.
摘要翻译： 本发明提供了新的脂氧素类似物，含有类似物的组合物，以及使用这些化合物和组合物治疗和预防口腔炎症的方法，包括牙龈炎，牙周炎和其他形式的牙周病。 本发明还提供了含有COX-2抑制剂的组合物治疗和预防口腔炎症的方法，包括牙龈炎，牙周炎和其他形式的牙周病。 此外，本发明提供了使用含有脂氧素类似物，COX-2抑制剂或两者的组合物来预防与口腔疾病相关的全腔外疾病的方法。
-
公开(公告)号：US20090247766A1
公开(公告)日：2009-10-01
申请号：US12413488
申请日：2009-03-27
IPC分类号： C07D409/04 , C07D495/04 , C07D407/04 , C07D209/10
CPC分类号： C07D209/12 , C07D209/08 , C07D209/40 , C07D209/42 , C07D209/80
摘要： The invention relates to a nitrogen heterocycle compound of formula 1: Also disclosed are a method of synthesizing the compound and use of the compound for treating various diseases and conditions.
摘要翻译： 本发明涉及式1的氮杂环化合物：还公开了合成化合物的方法和该化合物用于治疗各种疾病和病症的用途。
-
公开(公告)号：US07420000B2
公开(公告)日：2008-09-02
申请号：US10938256
申请日：2004-09-10
申请人： Nicos A. Petasis
发明人： Nicos A. Petasis
CPC分类号： A01N57/18 , A01N57/24 , A01N57/36 , C07F9/3808 , C07F9/4006 , C07F9/58 , C07F9/65515 , C07F9/65586 , C07F9/65846
摘要： Aminophosphonate and amino bisphosphonate compounds and methods for their preparation are provided. Also provided are pharmaceutical and agricultural compositions containing the compounds. The compounds and compositions are useful in methods for treatment of various diseases, including, inflammation, autoimmune disease, cardiovascular disease, bacterial infection, viral disease, abnormal cell proliferation, bone resorption disease, osteoporosis, or parasitic disease and in various agricultural methods, including, methods of eradicating weeds.
摘要翻译： 提供了氨基膦酸盐和氨基二膦酸盐化合物及其制备方法。 还提供含有这些化合物的药物和农业组合物。 化合物和组合物可用于治疗各种疾病的方法，包括炎症，自身免疫性疾病，心血管疾病，细菌感染，病毒性疾病，异常细胞增殖，骨吸收疾病，骨质疏松症或寄生虫病以及各种农业方法，包括 ，消除杂草的方法。
-
公开(公告)号：US06927294B1
公开(公告)日：2005-08-09
申请号：US10386389
申请日：2003-03-10
申请人： Nicos A. Petasis , Xin Yao , Jeffrey C. Raber
发明人： Nicos A. Petasis , Xin Yao , Jeffrey C. Raber
IPC分类号： C07D211/40 , C07D221/02 , C07D405/04 , C07D471/04
CPC分类号： C07D211/40 , C07D405/04 , C07D471/04
摘要： Functionalized nitrogen heterocyclic compounds, including benzodiazepines and azasugars, and synthetic methods for preparing such compounds. Nitrogen-containing heterocycles are prepared by reacting amino-carbonyl compounds that contain an amine moiety connected via a linker to a carbonyl moiety with an organoboron derivative.
摘要翻译： 官能化的氮杂环化合物，包括苯并二氮杂和氮杂异构体，以及制备这些化合物的合成方法。 通过将含有通过连接基连接的胺部分的氨基羰基化合物与羰基部分与有机硼衍生物反应制备含氮杂环。
-
公开(公告)号：US6030715A
公开(公告)日：2000-02-29
申请号：US948130
申请日：1997-10-09
IPC分类号： C07C211/61 , C07D223/14 , C07D223/26 , C07D487/22 , C09K11/06 , H01L51/00 , H01L51/30 , H01L51/50 , H01L51/52 , H05B33/14 , H05B33/28 , H05B33/26
CPC分类号： H01L51/0077 , C07C211/61 , C07D223/14 , C07D223/26 , C09B23/04 , C09B57/00 , C09K11/06 , H01L51/0053 , H01L51/0069 , H01L51/0071 , H01L51/0079 , H05B33/14 , H05B33/28 , C07C2103/18 , C07C2103/26 , C09K2211/1033 , C09K2211/1044 , C09K2211/1074 , C09K2211/185 , C09K2211/186 , H01L2251/308 , H01L2251/5323 , H01L51/0081 , H01L51/5012 , H01L51/5016 , Y10S428/917
摘要： Organic light emitting devices are disclosed which are comprised of a heterostructure for producing electoluminescence wherein the heterostructure is comprised of an emissive layer containing a dopant compound selected from the class of azlactone-related compounds having the chemical structure as represented by formula I: ##STR1## where R is hydrogen or a donor or acceptor group relative to hydrogen; R'=alkyl or substituted or unsubstituted aryl;R.sub.1 and R.sub.2 are hydrogen or are joined to form a fused aryl ring;X is O; NR.sub.5, where R.sub.5 is hydrogen or substituted or unsubstituted alkyl; alkyl or substituted or unsubstituted aryl;Z.sub.1 and Z.sub.2 are, independently of one another, a carbon or nitrogen atom; andY is M, a metal atom, whenever Z.sub.1 and Z.sub.2 are both nitrogen atoms;Y is O; NR.sub.6, where R.sub.6 is hydrogen or substituted or unsubstituted alkyl; or S; whenever either Z.sub.1 or Z.sub.2 is a carbon atom; orY is absent.
摘要翻译： 公开了由用于产生电致发光的异质结构组成的有机发光器件，其中异质结构由含有掺杂剂化合物的发射层组成，该掺杂剂化合物选自具有由式I表示的化学结构的吖内酯相关化合物：其中R为 氢或相对于氢的供体或受体基团; R'=烷基或取代或未取代的芳基; R1和R2是氢或连接形成稠合芳基环; X是O; NR5，其中R5是氢或取代或未取代的烷基; 烷基或取代或未取代的芳基; Z 1和Z 2彼此独立地为碳或氮原子; 而每当Z 1和Z 2均为氮原子时，Y为M为金属原子; Y是O; NR6，其中R6是氢或取代或未取代的烷基; 或S; 每当Z1或Z2是碳原子时; 或Y不存在。
-
公开(公告)号：US08461201B2
公开(公告)日：2013-06-11
申请号：US13042156
申请日：2011-03-07
申请人： Nicos A. Petasis
发明人： Nicos A. Petasis
IPC分类号： A01N37/06
CPC分类号： C07F7/1892 , C07B2200/05 , C07C67/303 , C07F7/081 , C07C69/732
摘要： The invention features methods for the preparation of naturally occurring trihydroxy polyunsaturated eicosanoids and their structural analogs. The invention further provides new derivatives and analogs of trihydroxy polyunsaturated eicosanoids that can be prepared according to these methods. The invention also provides compositions and methods using trihydroxy polyunsaturated eicosanoid derivatives for the prevention, amelioration and treatment of a variety of diseases or conditions associated with inflammation or inflammatory response, autoimmune diseases, rheumatoid arthritis, cardiovascular diseases, or abnormal cell proliferation or cancer.
-
-
-
-
-
-
-
-
-
搜索结果
44 条记录 (耗时 0.036 秒)
