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公开(公告)号:US20120258107A1
公开(公告)日:2012-10-11
申请号:US13498504
申请日:2010-09-29
申请人: Niels Jonas Heilskov Graversen , Pia Svendsen , Peter Astrup Christensen , Maciej Bogdan Maniecki , Søren Kragh Moestrup , Holger Jon Møller , Gabriele Anton
发明人: Niels Jonas Heilskov Graversen , Pia Svendsen , Peter Astrup Christensen , Maciej Bogdan Maniecki , Søren Kragh Moestrup , Holger Jon Møller , Gabriele Anton
IPC分类号: C07K16/28 , G01N33/566 , A61K39/395 , A61P37/00 , A61P37/06 , A61P35/00 , A61P31/00 , C07K16/30 , A61P29/00
CPC分类号: A61K47/6851 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/92 , Y02A50/41
摘要: The present invention relates to agents comprising a binding moiety with binding specificity for SRCR domain 1 of the CD163 receptor, for use in medicine. The invention also relates to methods, uses, kits and compositions comprising such agents.
摘要翻译: 本发明涉及包含对CD163受体的SRCR结构域1具有结合特异性的结合部分的药剂,用于药物。 本发明还涉及包含这些试剂的方法,用途,试剂盒和组合物。
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公开(公告)号:US09724426B2
公开(公告)日:2017-08-08
申请号:US13498504
申请日:2010-09-29
申请人: Niels Jonas Heilskov Graversen , Pia Svendsen , Peter Astrup Christensen , Maciej Bogdan Maniecki , Søren Kragh Moestrup , Holger Jon Møller , Gabriele Anton
发明人: Niels Jonas Heilskov Graversen , Pia Svendsen , Peter Astrup Christensen , Maciej Bogdan Maniecki , Søren Kragh Moestrup , Holger Jon Møller , Gabriele Anton
IPC分类号: A61K39/395 , C07K16/28 , A61K47/48 , A61K51/10 , A61K39/00
CPC分类号: A61K47/6851 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/92 , Y02A50/41
摘要: The present invention relates to agents comprising a binding moiety with binding specificity for SRCR domain 1 of the CD163 receptor, for use in medicine. The invention also relates to methods, uses, kits and compositions comprising such agents.
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公开(公告)号:US20120276193A1
公开(公告)日:2012-11-01
申请号:US13498511
申请日:2010-09-29
申请人: Niels Jonas Heilskov Graversen , Pia Svendsen , Peter Astrup Christensen , Søren Kragh Moestrup , Holger Jon Møller , Gabriele Anton
发明人: Niels Jonas Heilskov Graversen , Pia Svendsen , Peter Astrup Christensen , Søren Kragh Moestrup , Holger Jon Møller , Gabriele Anton
IPC分类号: A61K39/395 , A61P29/00 , A61P37/06 , A61K39/44 , A61K9/127
CPC分类号: A61K31/573 , A61K31/58 , A61K47/6803 , A61K47/6849 , A61K47/6913 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/622
摘要: The present invention relates to therapeutic agents for the targeted delivery of an immunosuppressive agent to monocytes and/or monocyte-derived cells comprising a binding moiety with specificity for monocytes and/or monocyte-derived cells and an immunosuppressive agent. In one embodiment, the agent is a glucocorticoid-antibody conjugate. The invention also relates to methods, uses, kits and compositions comprising such agents.
摘要翻译: 本发明涉及用于向单核细胞和/或单核细胞衍生的细胞靶向递送免疫抑制剂的治疗剂,其包含对单核细胞和/或单核细胞衍生的细胞和免疫抑制剂具有特异性的结合部分。 在一个实施方案中,所述试剂是糖皮质激素 - 抗体缀合物。 本发明还涉及包含这些试剂的方法,用途,试剂盒和组合物。
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公开(公告)号:US20120149877A1
公开(公告)日:2012-06-14
申请号:US13302698
申请日:2011-11-22
申请人: Steffen Goletz , Antje Danielczyk , Uwe Karsten , Peter Ravn , Renate Stahn , Peter Astrup Christensen
发明人: Steffen Goletz , Antje Danielczyk , Uwe Karsten , Peter Ravn , Renate Stahn , Peter Astrup Christensen
CPC分类号: A61K51/1045 , A61K47/6851 , A61K47/6903 , A61K2039/505 , C07K16/3076 , C07K2317/24 , C07K2317/622 , C07K2317/626 , C07K2319/00
摘要: The invention relates to recognition molecules which are directed towards tumors and can be used in the diagnosis and therapy of tumor diseases.
摘要翻译: 本发明涉及指向肿瘤并可用于诊断和治疗肿瘤疾病的识别分子。
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公开(公告)号:US08088357B2
公开(公告)日:2012-01-03
申请号:US10536834
申请日:2003-12-01
申请人: Steffen Goletz , Antje Danielczyk , Uwe Karsten , Peter Ravn , Renate Stahn , Peter Astrup Christensen
发明人: Steffen Goletz , Antje Danielczyk , Uwe Karsten , Peter Ravn , Renate Stahn , Peter Astrup Christensen
IPC分类号: A61K39/395 , C07K16/18 , C07K16/30 , G01N33/574 , G01N33/577
CPC分类号: A61K51/1045 , A61K47/6851 , A61K47/6903 , A61K2039/505 , C07K16/3076 , C07K2317/24 , C07K2317/622 , C07K2317/626 , C07K2319/00
摘要: The invention relates to recognition molecules which are directed towards tumors and can be used in the diagnosis and therapy of tumor diseases.
摘要翻译: 本发明涉及指向肿瘤并可用于诊断和治疗肿瘤疾病的识别分子。
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公开(公告)号:US08617846B2
公开(公告)日:2013-12-31
申请号:US13302698
申请日:2011-11-22
申请人: Steffen Goletz , Antje Danielczyk , Uwe Karsten , Peter Ravn , Renate Stahn , Peter Astrup Christensen
发明人: Steffen Goletz , Antje Danielczyk , Uwe Karsten , Peter Ravn , Renate Stahn , Peter Astrup Christensen
IPC分类号: C12P21/08 , C07K16/30 , A61K39/395
CPC分类号: A61K51/1045 , A61K47/6851 , A61K47/6903 , A61K2039/505 , C07K16/3076 , C07K2317/24 , C07K2317/622 , C07K2317/626 , C07K2319/00
摘要: The invention relates to recognition molecules which are directed towards tumors and can be used in the diagnosis and therapy of tumor diseases.
摘要翻译: 本发明涉及指向肿瘤并可用于诊断和治疗肿瘤疾病的识别分子。
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