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公开(公告)号:US08653092B2
公开(公告)日:2014-02-18
申请号:US13175050
申请日:2011-07-01
申请人: Nigel Graham Cooke , Paulo Fernandes Gomes Dos Santos , Nadege Graveleau , Christina Hebach , Klemens Högenauer , Gregory Hollingworth , Alexander Baxter Smith , Nicolas Soldermann , Frank Stowasser , Ross Strang , Nicola Tufilli , Anette Von Matt , Romain Wolf , Frédéric Zecri
发明人: Nigel Graham Cooke , Paulo Fernandes Gomes Dos Santos , Nadege Graveleau , Christina Hebach , Klemens Högenauer , Gregory Hollingworth , Alexander Baxter Smith , Nicolas Soldermann , Frank Stowasser , Ross Strang , Nicola Tufilli , Anette Von Matt , Romain Wolf , Frédéric Zecri
IPC分类号: C07D471/04 , A61K31/519 , A61P37/08 , A61P25/28 , A61P35/00 , A61P37/06
CPC分类号: C07D471/04 , A61K31/519 , A61K31/5377 , C07B2200/05
摘要: The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.
摘要翻译: 本发明涉及式(I)的取代的四氢 - 吡啶并 - 嘧啶衍生物,其中Y,R 1,R 2和m如说明书中所定义。 这些化合物适用于治疗由PI3K酶的活性介导的病症或疾病。
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公开(公告)号:US09499536B2
公开(公告)日:2016-11-22
申请号:US14151796
申请日:2014-01-09
申请人: Nigel Graham Cooke , Frédèric Zecri , Nicolas Soldermann , Romain Wolf , Christina Hebach , Klemens Hoegenauer , Gregory John Hollingworth , Anette Von Matt , Ross Sinclair Strang , Alexander Baxter Smith , Paulo Fernandes Gomes Dos Santos , Nadege Graveleau , Frank Stowasser , Nicola Tufilli
发明人: Nigel Graham Cooke , Frédèric Zecri , Nicolas Soldermann , Romain Wolf , Christina Hebach , Klemens Hoegenauer , Gregory John Hollingworth , Anette Von Matt , Ross Sinclair Strang , Alexander Baxter Smith , Paulo Fernandes Gomes Dos Santos , Nadege Graveleau , Frank Stowasser , Nicola Tufilli
IPC分类号: A61K31/519 , A61P35/02 , A61P19/02 , C07D471/04
CPC分类号: C07D471/04 , A61K31/519 , A61K31/5377 , C07B2200/05
摘要: The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.
摘要翻译: 本发明涉及式(I)的取代的四氢 - 吡啶并 - 嘧啶衍生物,其中Y,R 1,R 2和m如说明书中所定义。 这些化合物适用于治疗由PI3K酶的活性介导的病症或疾病。
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3.2,4- Di(hetero)-arylamino-pyrimidine derivatives as ZAP-70 and/or SYK inhibitors 失效
标题翻译: 2,4-二(杂) - 芳基氨基 - 嘧啶衍生物,为ZAP-70和/或SYK抑制剂公开(公告)号:US08283356B2
公开(公告)日:2012-10-09
申请号:US12686863
申请日:2010-01-13
申请人: Rolf Baenteli , Marie Claude Bernhard , Peter Buehlmayer , Nigel Graham Cooke , Rudolf Duthaler , Klaus Hinterding , Gebhard Thoma , Maurice Van Eis , Anette Von Matt , Louis Walliser , Gerhard Zenke
发明人: Rolf Baenteli , Marie Claude Bernhard , Peter Buehlmayer , Nigel Graham Cooke , Rudolf Duthaler , Klaus Hinterding , Gebhard Thoma , Maurice Van Eis , Anette Von Matt , Louis Walliser , Gerhard Zenke
IPC分类号: C07D405/12 , C07D239/48 , C07D413/14 , A61K31/506
CPC分类号: C07D239/48 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , Y02P20/582
摘要: Disclosed are pyrimidine derivatives of formula wherein R0, R1, R3 to R9, and Z have a signification as indicated in claim 1, which have interesting pharmaceutical properties.
摘要翻译: 公开了下式的嘧啶衍生物其中R 0,R 1,R 3至R 9和Z具有如权利要求1所示的含义,其具有有趣的药物性质。
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公开(公告)号:US07943627B2
公开(公告)日:2011-05-17
申请号:US10507060
申请日:2003-03-14
申请人: Rolf Baenteli , Gerhard Zenke , Nigel Graham Cooke , Rudolf Duthaler , Gebhard Thoma , Anette Von Matt , Toshiyuki Honda , Naoko Matsuura , Kazuhiko Nonomura , Osamu Ohmori , Ichiro Umemura , Klaus Hinterding , Christos Papageorgiou
发明人: Rolf Baenteli , Gerhard Zenke , Nigel Graham Cooke , Rudolf Duthaler , Gebhard Thoma , Anette Von Matt , Toshiyuki Honda , Naoko Matsuura , Kazuhiko Nonomura , Osamu Ohmori , Ichiro Umemura , Klaus Hinterding , Christos Papageorgiou
IPC分类号: C07D239/48 , A61K31/505
CPC分类号: C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12
摘要: There are provided compounds of formula I wherein X, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as indicated in claim 1, useful in disorders where ZAP-70 and/or Syk inhibition plays a role or caused by a malfunction of signal cascades connected with FAK.
摘要翻译: 提供式I化合物,其中X,R 1,R 2,R 3,R 4,R 5,R 6,R 7,R 8和R 9如权利要求1所述,其可用于ZAP-70和/或Syk抑制起作用或 由与FAK连接的信号级联故障引起的。
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5.2,4 Di (hetero) -arylamino-pyrimidine derivatives as ZAP-70 and/or syk inhibitors 失效
标题翻译: 2,4-二(杂) - 芳基氨基 - 嘧啶衍生物,如ZAP-70和/或syk抑制剂公开(公告)号:US07671063B2
公开(公告)日:2010-03-02
申请号:US11377716
申请日:2006-03-16
申请人: Rolf Baenteli , Marie Claude Bernhard , Peter Buehlmayer , Nigel Graham Cooke , Rudolf Duthaler , Klaus Hinterding , Gebhard Thoma , Maurice Van Eis , Anette Von Matt , Louis Walliser , Gerhard Zenke
发明人: Rolf Baenteli , Marie Claude Bernhard , Peter Buehlmayer , Nigel Graham Cooke , Rudolf Duthaler , Klaus Hinterding , Gebhard Thoma , Maurice Van Eis , Anette Von Matt , Louis Walliser , Gerhard Zenke
IPC分类号: C07D405/12 , C07D239/48 , C07D413/14 , A61K31/506
CPC分类号: C07D239/48 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , Y02P20/582
摘要: Disclosed are pyrimidine derivatives of formula wherein R0, R1, R3 to R9, and Z have a signification as indicated in claim 1, which have interesting pharmaceutical properties.
摘要翻译: 公开了下式的嘧啶衍生物其中R 0,R 1,R 3至R 9和Z具有如权利要求1所示的含义,其具有有趣的药物性质。
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公开(公告)号:US08431589B2
公开(公告)日:2013-04-30
申请号:US13069816
申请日:2011-03-23
申请人: Rolf Baenteli , Gerhard Zenke , Nigel Graham Cooke , Rudolf Duthaler , Gebhard Thoma , Anette Von Matt , Toshiyuki Honda , Naoko Matsuura , Kazuhiko Nonomura , Osamu Ohmori , Ichiro Umemura , Klaus Hinterding , Christos Papageorgiou
发明人: Rolf Baenteli , Gerhard Zenke , Nigel Graham Cooke , Rudolf Duthaler , Gebhard Thoma , Anette Von Matt , Toshiyuki Honda , Naoko Matsuura , Kazuhiko Nonomura , Osamu Ohmori , Ichiro Umemura , Klaus Hinterding , Christos Papageorgiou
IPC分类号: C07D239/48 , A61K31/505
CPC分类号: C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12
摘要: There are provided compounds of formula I wherein X, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as indicated in claim 1 , useful in disorders where ZAP-70 and/or Syk inhibition plays a role or caused by a malfunction of signal cascades connected with FAK.
摘要翻译: 提供式I化合物,其中X,R 1,R 2,R 3,R 4,R 5,R 6,R 7,R 8和R 9如权利要求1所述,其可用于ZAP-70和/或Syk抑制起作用或 由与FAK连接的信号级联故障引起的。
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公开(公告)号:US20110172231A1
公开(公告)日:2011-07-14
申请号:US13069816
申请日:2011-03-23
申请人: Rolf BAENTELI , Gerhard Zenke , Nigel Graham Cooke , Rudolf Duthaler , Gebhard Thoma , Anette Von Matt , Toshiyuki Honda , Naoko Matsuura , Kazuhiko Nonomura , Osamu Ohmori , Ichiro Umemura , Klaus Hinterding , Christos Papageorgiou
发明人: Rolf BAENTELI , Gerhard Zenke , Nigel Graham Cooke , Rudolf Duthaler , Gebhard Thoma , Anette Von Matt , Toshiyuki Honda , Naoko Matsuura , Kazuhiko Nonomura , Osamu Ohmori , Ichiro Umemura , Klaus Hinterding , Christos Papageorgiou
IPC分类号: A61K31/5377 , C07D403/12 , A61K31/506 , A61P29/00 , A61P35/00 , A61P35/02 , C07D239/48 , C07D413/12 , A61K31/496
CPC分类号: C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12
摘要: There are provided compounds of formula I wherein X, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as indicated in claim 1, useful in disorders where ZAP-70 and/or Syk inhibition plays a role or caused by a malfunction of signal cascades connected with FAK.
摘要翻译: 提供式I化合物,其中X,R 1,R 2,R 3,R 4,R 5,R 6,R 7,R 8和R 9如权利要求1所述,其可用于ZAP-70和/或Syk抑制起作用或 由与FAK连接的信号级联故障引起的。
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8.2,4- Di(hetero)-arylamino-pyrimidine Derivatives as ZAP-70 and/or SYK inhibitors 失效
标题翻译: 2,4-二(杂) - 芳基氨基 - 嘧啶衍生物,为ZAP-70和/或SYK抑制剂公开(公告)号:US20100152182A1
公开(公告)日:2010-06-17
申请号:US12686863
申请日:2010-01-13
申请人: Rolf Baenteli , Marie Claude Bernhard , Peter Buehlmayer , Nigel Graham Cooke , Rudolf Duthaler , Klaus Hinterding , Gebhard Thoma , Maurice Van Eis , Anette Von Matt , Louis Walliser , Gerhard Zenke
发明人: Rolf Baenteli , Marie Claude Bernhard , Peter Buehlmayer , Nigel Graham Cooke , Rudolf Duthaler , Klaus Hinterding , Gebhard Thoma , Maurice Van Eis , Anette Von Matt , Louis Walliser , Gerhard Zenke
IPC分类号: A61K31/5377 , C07D239/69 , A61K31/506 , A61P35/00 , A61P37/00 , A61P7/00 , C07D413/14
CPC分类号: C07D239/48 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , Y02P20/582
摘要: Disclosed are pyrimidine derivatives of formula wherein R0, R1, R3 to R9, and Z have a signification as indicated in claim 1, which have interesting pharmaceutical properties.
摘要翻译: 公开了下式的嘧啶衍生物其中R 0,R 1,R 3至R 9和Z具有如权利要求1所示的含义,其具有有趣的药物性质。
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公开(公告)号:US20100144729A1
公开(公告)日:2010-06-10
申请号:US12524943
申请日:2008-01-31
IPC分类号: A61K31/5377 , C07D311/02 , A61K31/366 , C07D405/12 , A61K31/4025 , A61K31/453 , C07D413/12
CPC分类号: C07D311/16 , C07D311/18
摘要: A compound of formula (I) wherein R1, R2, R3 and R4 are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.
摘要翻译: 其中R 1,R 2,R 3和R 4如说明书中所定义的式(I)化合物,其制备方法,用途,特别是在移植中,以及含有它们的药物组合物。
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公开(公告)号:US09029396B2
公开(公告)日:2015-05-12
申请号:US14194879
申请日:2014-03-03
IPC分类号: C07D215/04 , A61K31/47 , A61K31/499 , C07D401/14 , C07F9/6558 , A61K31/675
CPC分类号: A61K31/499 , A61K31/675 , A61K45/06 , C07D401/14 , C07F9/65583
摘要: The present invention relates to substituted indole derivatives, to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
摘要翻译: 本发明涉及取代的吲哚衍生物,其制备方法,它们作为药物的用途以及包含它们的药物组合物。
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