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公开(公告)号:US20100144729A1
公开(公告)日:2010-06-10
申请号:US12524943
申请日:2008-01-31
IPC分类号: A61K31/5377 , C07D311/02 , A61K31/366 , C07D405/12 , A61K31/4025 , A61K31/453 , C07D413/12
CPC分类号: C07D311/16 , C07D311/18
摘要: A compound of formula (I) wherein R1, R2, R3 and R4 are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.
摘要翻译: 其中R 1,R 2,R 3和R 4如说明书中所定义的式(I)化合物,其制备方法,用途,特别是在移植中,以及含有它们的药物组合物。
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公开(公告)号:US20090318546A1
公开(公告)日:2009-12-24
申请号:US12296317
申请日:2007-04-10
申请人: Rolf Baenteli , Nigel Graham Cooke , Sven Weiler , Frederic Zecri
发明人: Rolf Baenteli , Nigel Graham Cooke , Sven Weiler , Frederic Zecri
IPC分类号: A61K31/37 , C07D311/04 , A61P37/02
CPC分类号: C07D311/16
摘要: A compound of formula (I) wherein R1, R2, R3, R4, R5, and ring A are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.
摘要翻译: 其中R 1,R 2,R 3,R 4,R 5和环A如说明书中所定义的式(I)化合物处理其制备,其用途,特别是移植,以及含有它们的药物组合物。
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公开(公告)号:US07943627B2
公开(公告)日:2011-05-17
申请号:US10507060
申请日:2003-03-14
申请人: Rolf Baenteli , Gerhard Zenke , Nigel Graham Cooke , Rudolf Duthaler , Gebhard Thoma , Anette Von Matt , Toshiyuki Honda , Naoko Matsuura , Kazuhiko Nonomura , Osamu Ohmori , Ichiro Umemura , Klaus Hinterding , Christos Papageorgiou
发明人: Rolf Baenteli , Gerhard Zenke , Nigel Graham Cooke , Rudolf Duthaler , Gebhard Thoma , Anette Von Matt , Toshiyuki Honda , Naoko Matsuura , Kazuhiko Nonomura , Osamu Ohmori , Ichiro Umemura , Klaus Hinterding , Christos Papageorgiou
IPC分类号: C07D239/48 , A61K31/505
CPC分类号: C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12
摘要: There are provided compounds of formula I wherein X, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as indicated in claim 1, useful in disorders where ZAP-70 and/or Syk inhibition plays a role or caused by a malfunction of signal cascades connected with FAK.
摘要翻译: 提供式I化合物,其中X,R 1,R 2,R 3,R 4,R 5,R 6,R 7,R 8和R 9如权利要求1所述,其可用于ZAP-70和/或Syk抑制起作用或 由与FAK连接的信号级联故障引起的。
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4.2,4 Di (hetero) -arylamino-pyrimidine derivatives as ZAP-70 and/or syk inhibitors 失效
标题翻译: 2,4-二(杂) - 芳基氨基 - 嘧啶衍生物,如ZAP-70和/或syk抑制剂公开(公告)号:US07671063B2
公开(公告)日:2010-03-02
申请号:US11377716
申请日:2006-03-16
申请人: Rolf Baenteli , Marie Claude Bernhard , Peter Buehlmayer , Nigel Graham Cooke , Rudolf Duthaler , Klaus Hinterding , Gebhard Thoma , Maurice Van Eis , Anette Von Matt , Louis Walliser , Gerhard Zenke
发明人: Rolf Baenteli , Marie Claude Bernhard , Peter Buehlmayer , Nigel Graham Cooke , Rudolf Duthaler , Klaus Hinterding , Gebhard Thoma , Maurice Van Eis , Anette Von Matt , Louis Walliser , Gerhard Zenke
IPC分类号: C07D405/12 , C07D239/48 , C07D413/14 , A61K31/506
CPC分类号: C07D239/48 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , Y02P20/582
摘要: Disclosed are pyrimidine derivatives of formula wherein R0, R1, R3 to R9, and Z have a signification as indicated in claim 1, which have interesting pharmaceutical properties.
摘要翻译: 公开了下式的嘧啶衍生物其中R 0,R 1,R 3至R 9和Z具有如权利要求1所示的含义,其具有有趣的药物性质。
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5.2,4- Di(hetero)-arylamino-pyrimidine derivatives as ZAP-70 and/or SYK inhibitors 失效
标题翻译: 2,4-二(杂) - 芳基氨基 - 嘧啶衍生物,为ZAP-70和/或SYK抑制剂公开(公告)号:US08283356B2
公开(公告)日:2012-10-09
申请号:US12686863
申请日:2010-01-13
申请人: Rolf Baenteli , Marie Claude Bernhard , Peter Buehlmayer , Nigel Graham Cooke , Rudolf Duthaler , Klaus Hinterding , Gebhard Thoma , Maurice Van Eis , Anette Von Matt , Louis Walliser , Gerhard Zenke
发明人: Rolf Baenteli , Marie Claude Bernhard , Peter Buehlmayer , Nigel Graham Cooke , Rudolf Duthaler , Klaus Hinterding , Gebhard Thoma , Maurice Van Eis , Anette Von Matt , Louis Walliser , Gerhard Zenke
IPC分类号: C07D405/12 , C07D239/48 , C07D413/14 , A61K31/506
CPC分类号: C07D239/48 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , Y02P20/582
摘要: Disclosed are pyrimidine derivatives of formula wherein R0, R1, R3 to R9, and Z have a signification as indicated in claim 1, which have interesting pharmaceutical properties.
摘要翻译: 公开了下式的嘧啶衍生物其中R 0,R 1,R 3至R 9和Z具有如权利要求1所示的含义,其具有有趣的药物性质。
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6.2,4- Di(hetero)-arylamino-pyrimidine Derivatives as ZAP-70 and/or SYK inhibitors 失效
标题翻译: 2,4-二(杂) - 芳基氨基 - 嘧啶衍生物,为ZAP-70和/或SYK抑制剂公开(公告)号:US20100152182A1
公开(公告)日:2010-06-17
申请号:US12686863
申请日:2010-01-13
申请人: Rolf Baenteli , Marie Claude Bernhard , Peter Buehlmayer , Nigel Graham Cooke , Rudolf Duthaler , Klaus Hinterding , Gebhard Thoma , Maurice Van Eis , Anette Von Matt , Louis Walliser , Gerhard Zenke
发明人: Rolf Baenteli , Marie Claude Bernhard , Peter Buehlmayer , Nigel Graham Cooke , Rudolf Duthaler , Klaus Hinterding , Gebhard Thoma , Maurice Van Eis , Anette Von Matt , Louis Walliser , Gerhard Zenke
IPC分类号: A61K31/5377 , C07D239/69 , A61K31/506 , A61P35/00 , A61P37/00 , A61P7/00 , C07D413/14
CPC分类号: C07D239/48 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , Y02P20/582
摘要: Disclosed are pyrimidine derivatives of formula wherein R0, R1, R3 to R9, and Z have a signification as indicated in claim 1, which have interesting pharmaceutical properties.
摘要翻译: 公开了下式的嘧啶衍生物其中R 0,R 1,R 3至R 9和Z具有如权利要求1所示的含义,其具有有趣的药物性质。
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公开(公告)号:US08431589B2
公开(公告)日:2013-04-30
申请号:US13069816
申请日:2011-03-23
申请人: Rolf Baenteli , Gerhard Zenke , Nigel Graham Cooke , Rudolf Duthaler , Gebhard Thoma , Anette Von Matt , Toshiyuki Honda , Naoko Matsuura , Kazuhiko Nonomura , Osamu Ohmori , Ichiro Umemura , Klaus Hinterding , Christos Papageorgiou
发明人: Rolf Baenteli , Gerhard Zenke , Nigel Graham Cooke , Rudolf Duthaler , Gebhard Thoma , Anette Von Matt , Toshiyuki Honda , Naoko Matsuura , Kazuhiko Nonomura , Osamu Ohmori , Ichiro Umemura , Klaus Hinterding , Christos Papageorgiou
IPC分类号: C07D239/48 , A61K31/505
CPC分类号: C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12
摘要: There are provided compounds of formula I wherein X, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as indicated in claim 1 , useful in disorders where ZAP-70 and/or Syk inhibition plays a role or caused by a malfunction of signal cascades connected with FAK.
摘要翻译: 提供式I化合物,其中X,R 1,R 2,R 3,R 4,R 5,R 6,R 7,R 8和R 9如权利要求1所述,其可用于ZAP-70和/或Syk抑制起作用或 由与FAK连接的信号级联故障引起的。
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8.Use of 9H-Purine-2,6-Diamine Derivatives in the Treatment of Proliferative Diseases and Novel 9H-Purine-2,6-Diamine Derivatives 审中-公开
标题翻译: 9H-嘌呤-2,6-二胺衍生物在增殖性疾病和新型9H-嘌呤-2,6-二胺衍生物的治疗中的应用公开(公告)号:US20070249639A1
公开(公告)日:2007-10-25
申请号:US10594412
申请日:2005-04-04
申请人: Rolf Baenteli , Patrick Chene , Stephen Collingwood , Pascal Furet , Peter Meier , Joseph Schoepfer
发明人: Rolf Baenteli , Patrick Chene , Stephen Collingwood , Pascal Furet , Peter Meier , Joseph Schoepfer
IPC分类号: A61K31/52 , C07D473/00
CPC分类号: C07D239/48 , A61K31/52 , C07D473/16
摘要: The invention relates to the use of 9H-purine-2,6-diamine compounds and salts thereof in the treatment of proliferative diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, pharmaceutical preparations comprising 9H-purine-2,6-diamine compounds, novel 9H-purine-2,6-diamine compounds, and a process for the preparation of the novel 9H-purine-2,6-diamine compounds.
摘要翻译: 本发明涉及9H-嘌呤-2,6-二胺化合物及其盐在治疗增殖性疾病和制备用于治疗所述疾病的药物制剂中的用途,包括9H-嘌呤-2,6 - 二胺化合物,新的9H-嘌呤-2,6-二胺化合物,以及制备新型9H-嘌呤-2,6-二胺化合物的方法。
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9.2,4 Di (hetero) -arylamino-pyrimidine derivatives as ZAP-70 and/or syk inhibitors 失效
标题翻译: 2,4-二(杂) - 芳基氨基 - 嘧啶衍生物,如ZAP-70和/或syk抑制剂公开(公告)号:US20060247262A1
公开(公告)日:2006-11-02
申请号:US11377716
申请日:2006-03-16
申请人: Rolf Baenteli , Marie Bernhard , Peter Buehlmayer , Nigel Cooke , Rudolf Duthaler , Klaus Hinterding , Gebhard Thoma , Maurice Van Eis , Anette Von Matt , Louis Walliser , Gerhard Zenke
发明人: Rolf Baenteli , Marie Bernhard , Peter Buehlmayer , Nigel Cooke , Rudolf Duthaler , Klaus Hinterding , Gebhard Thoma , Maurice Van Eis , Anette Von Matt , Louis Walliser , Gerhard Zenke
IPC分类号: A61K31/506 , C07D403/02
CPC分类号: C07D239/48 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , Y02P20/582
摘要: Disclosed are pyrimidine derivatives of formula wherein R0, R1, R3 to R9, and Z have a signification as indicated in claim 1, which have interesting pharmaceutical properties.
摘要翻译: 公开了下式的嘧啶衍生物其中R 0,R 1,R 3至R 9,Z具有 如权利要求1所述的含义,其具有有趣的药物性质。
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公开(公告)号:US20060100227A1
公开(公告)日:2006-05-11
申请号:US10507060
申请日:2003-03-14
申请人: Rolf Baenteli , Gerhard Zenke , Nigel Cooke , Rudolf Duthaler , Gebhard Thoma , Anette Von Matt , Toshiyuki Honda , Naoko Matsuura , Kazuhiko Nonomura , Osamu Ohmori , Ichiro Umemura , Klaus Hinterding , Christos Papageorgiou
发明人: Rolf Baenteli , Gerhard Zenke , Nigel Cooke , Rudolf Duthaler , Gebhard Thoma , Anette Von Matt , Toshiyuki Honda , Naoko Matsuura , Kazuhiko Nonomura , Osamu Ohmori , Ichiro Umemura , Klaus Hinterding , Christos Papageorgiou
IPC分类号: A61K31/505 , C07D403/02 , C07D239/48
CPC分类号: C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12
摘要: There are provided compounds of formula I Wherein X, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as indicated in claim 1, useful in disorders where ZAP-70 and/or Syk inhibition plays a role or caused by a malfunction of signal cascades connected with FAK.
摘要翻译: 提供式I的化合物,其中X,R 1,R 2,R 3,R 4, R 5,R 6,R 7,R 8和R 9均为 如权利要求1所述,其可用于ZAP-70和/或Syk抑制作用或由与FAK连接的信号级联的故障引起的疾病中。
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