公开(公告)号：US6117452A

公开(公告)日：2000-09-12

申请号：US132922

申请日：1998-08-12

申请人： Nils Ahlgren ,  Joseph Cascone ,  Joan Fitzpatrick ,  Steven E. Frisbee ,  John Getz ,  Mark R. Herman ,  Bernard M. Kiernan ,  Barbara Montwill ,  Ed O'Donnell ,  Desiree Pereira ,  Pradeepkumar P. Sanghvi

发明人： Nils Ahlgren ,  Joseph Cascone ,  Joan Fitzpatrick ,  Steven E. Frisbee ,  John Getz ,  Mark R. Herman ,  Bernard M. Kiernan ,  Barbara Montwill ,  Ed O'Donnell ,  Desiree Pereira ,  Pradeepkumar P. Sanghvi

IPC分类号： A61K9/16 ,  A61K9/26 ,  A61K9/50

CPC分类号： A61K9/1617

摘要： The thermoforming of compositions containing active agents is carried out by processing compositions containing certain fatty esters in combination.

摘要翻译： 包含活性剂的组合物的热成型通过组合含有某些脂肪酯的组合物进行。

公开(公告)号：US20110301131A1

公开(公告)日：2011-12-08

申请号：US13128057

申请日：2009-11-06

申请人： Joan Fitzpatrick ,  David Prior

发明人： Joan Fitzpatrick ,  David Prior

IPC分类号： A61K31/616 ,  A61K47/42 ,  A61K31/167 ,  A61K31/445 ,  A61K31/47 ,  A61K31/485 ,  A61K31/4468 ,  A61K31/454 ,  A61K31/4535 ,  A61K31/137 ,  A61K31/196 ,  A61K31/192 ,  A61K31/5415 ,  A61K31/405 ,  C07K1/107 ,  A61P23/00 ,  A61P25/04 ,  A61P29/00 ,  A61P31/00 ,  B01J19/08 ,  C07K14/78

CPC分类号： A61L31/044 ,  A61K9/0024 ,  A61K47/42 ,  A61L31/16 ,  A61L2300/00

摘要： The invention discloses an implant suitable for delivery of at least one drug, the implant comprising a fibrillar collagen matrix having, as measured in Example 1, a viscosity of greater than 100 mPas, optionally greater than 103 mPas, further optionally greater than 106 mPas, still further optionally greater than 109 mPas when a collagen dispersion formed from 140 mg of the fibrillar collagen matrix is dispersed in 25 ml of 2 mM HCl at a pH of less than 3.5 and at a temperature of 30.0+/−0.5° C. The invention also discloses a process for preparing an implant suitable for delivery of at least one drug, the process comprising the steps of forming a fibrillar collagen matrix from a collagen suspension; and carrying out a crosslinking step on either the fibrillar collagen matrix or the collagen suspension under conditions such that the fibrillar collagen matrix has, as measured in Example 1, a viscosity of greater than 100 mPas, optionally greater than 103 mPas, further optionally greater than 106 mPas, still further optionally greater than 109 mPas, when a collagen dispersion formed from 140 mg of the fibrillar collagen matrix is dispersed in 25 ml of 2 mM HCl at a pH of less than 3.5 and at a temperature of 30.0+/−0.5° C. The invention further discloses use of the aforementioned fibrillar collagen matrix for the manufacture of the aforementioned implant for extended local delivery adjacent the site of implantation of at least one drug from the implant.

摘要翻译： 本发明公开了适合于递送至少一种药物的植入物，所述植入物包含纤维状胶原基质，其具有如实施例1中测量的大于100mPas，任选地大于103mPas，进一步任选大于106mPas的粘度， 当将由140mg纤维状胶原基质形成的胶原分散体分散在25ml pH2.5的2mM HCl和30.0 +/- 0.5℃的温度下时，进一步可选地大于109mPas。 本发明还公开了一种制备适于递送至少一种药物的植入物的方法，所述方法包括以下步骤：从胶原悬浮液形成纤维状胶原基质; 并且在条件下在纤维状胶原基质或胶原悬浮液上进行交联步骤，使得如实施例1中测量的纤维状胶原基质的粘度大于100mPas，任选地大于103mPas，进一步可选地大于 当将140mg纤维状胶原基质形成的胶原分散体分散在25ml pH2.5的2mM HCl和30.0 +/- 0.5的温度下时，还可以大于109mPas。 本发明还公开了上述原纤维胶原蛋白基质用于制造上述植入物，用于在离植入物植入至少一种药物的位置附近进行延长的局部递送。