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公开(公告)号：US20210140881A1
公开(公告)日：2021-05-13
申请号：US17094901
申请日：2020-11-11
IPC分类号： G01N21/39 , C12M1/34 , G01N33/68 , G01N21/45 , G01N21/359 , G01N21/3577
摘要： A method for studying cell viability and protein aggregation involves establishing a Fabry Perot etalon signal within an optical spectroscopic feature, e.g., in the near infrared region. Protein aggregation and cell viability can be reflected by changes observed in the magnitude of the Fourier Transform peaks observed in the frequency or space domain associated with the contrast of the etalon. In short, the presence of viable cells and protein aggregates can degrade the etalon contrast of an etalon window. In some cases, the concentration of cells and monomeric protein can be measured as well.
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公开(公告)号：US12031908B2
公开(公告)日：2024-07-09
申请号：US17094901
申请日：2020-11-11
IPC分类号： B01L3/00 , B01F23/00 , B01F23/41 , B01F101/23 , B23Q17/24 , C12M1/34 , C12Q1/18 , G01N21/3577 , G01N21/359 , G01N21/39 , G01N21/45 , G01N21/64 , G01N33/50 , G01N33/68
CPC分类号： G01N21/39 , C12M41/32 , G01N21/3577 , G01N21/359 , G01N21/45 , G01N33/6854 , G01N2201/06113
摘要： A method for studying cell viability and protein aggregation involves establishing a Fabry Perot etalon signal within an optical spectroscopic feature, e.g., in the near infrared region. Protein aggregation and cell viability can be reflected by changes observed in the magnitude of the Fourier Transform peaks observed in the frequency or space domain associated with the contrast of the etalon. In short, the presence of viable cells and protein aggregates can degrade the etalon contrast of an etalon window. In some cases, the concentration of cells and monomeric protein can be measured as well.
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公开(公告)号：US20230034379A1
公开(公告)日：2023-02-02
申请号：US17965017
申请日：2022-10-13
发明人： Bryan A. Hassell , David P. Marchessault , Christopher R. Saulnier , John C. Ho , Walid A. Atia
摘要： A device for monitoring a bioreactor is configured for in-situ analysis, e.g., by NIR, without the need for withdrawing a sample into a sample cell or into an ex-situ arrangement. The device can be inserted into a port of the bioreactor and provides a sample detection region defined by an optical element such as a lens and a photodetector. The electrical signal obtained from a photodetector that is part of the device can be directed to an analyzer via a detachable electrical connection.
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公开(公告)号：US20240319090A1
公开(公告)日：2024-09-26
申请号：US18733911
申请日：2024-06-05
IPC分类号： G01N21/39 , C12M1/34 , G01N21/3577 , G01N21/359 , G01N21/45 , G01N33/68
CPC分类号： G01N21/39 , C12M41/32 , G01N21/3577 , G01N21/359 , G01N21/45 , G01N33/6854 , G01N2201/06113
摘要： A method for studying cell viability and protein aggregation involves establishing a Fabry Perot etalon signal within an optical spectroscopic feature, e.g., in the near infrared region. Protein aggregation and cell viability can be reflected by changes observed in the magnitude of the Fourier Transform peaks observed in the frequency or space domain associated with the contrast of the etalon. In short, the presence of viable cells and protein aggregates can degrade the etalon contrast of an etalon window. In some cases, the concentration of cells and monomeric protein can be measured as well.
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公开(公告)号：US11499903B2
公开(公告)日：2022-11-15
申请号：US17030032
申请日：2020-09-23
发明人： Bryan A. Hassell , David P. Marchessault , Christopher R. Saulnier , John C. Ho , Walid A. Atia
摘要： A device for monitoring a bioreactor is configured for in-situ analysis, e.g., by NIR, without the need for withdrawing a sample into a sample cell or into an ex-situ arrangement. The device can be inserted into a port of the bioreactor and provides a sample detection region defined by an optical element such as a lens and a photodetector. The electrical signal obtained from a photodetector that is part of the device can be directed to an analyzer via a detachable electrical connection.
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公开(公告)号：US20210088433A1
公开(公告)日：2021-03-25
申请号：US17030032
申请日：2020-09-23
发明人： Bryan A. Hassell , David P. Marchessault , Christopher R. Saulnier , John C. Ho , Walid A. Atia
摘要： A device for monitoring a bioreactor is configured for in-situ analysis, e.g., by NIR, without the need for withdrawing a sample into a sample cell or into an ex-situ arrangement. The device can be inserted into a port of the bioreactor and provides a sample detection region defined by an optical element such as a lens and a photodetector. The electrical signal obtained from a photodetector that is part of the device can be directed to an analyzer via a detachable electrical connection.
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