公开(公告)号：US08346363B2

公开(公告)日：2013-01-01

申请号：US11318845

申请日：2005-12-27

申请人： Nissim Darvish ,  Tami Harel ,  Bella Felsen

发明人： Nissim Darvish ,  Tami Harel ,  Bella Felsen

IPC分类号： A61N1/00

CPC分类号： A61N1/36007

摘要： A pancreatic controller, comprising: a glucose sensor, for sensing a level of glucose or insulin in a body serum; at least one electrode, for electrifying an insulin producing cell or group of cells; a power source for electrifying said electrode with a pulse that does not initiate an action potential in said cell and has an effect of increasing insulin secretion; and a controller which receives the sensed level and controls said power source to electrify said electrode to have a desired effect on said level.

摘要翻译： 一种胰脏控制器，包括：葡萄糖传感器，用于感测体内血清中的葡萄糖或胰岛素水平; 至少一个电极，用于给胰岛素产生细胞或一组细胞带电; 用于以不在所述细胞中引发动作电位的脉冲对所述电极充电并具有增加胰岛素分泌的作用的电源; 以及控制器，其接收所感测的电平并控制所述电源以使所述电极带电以对所述电平具有期望的效果。

公开(公告)号：US20060184207A1

公开(公告)日：2006-08-17

申请号：US11318845

申请日：2005-12-27

申请人： Nissim Darvish ,  Tami Harel ,  Bella Felsen

发明人： Nissim Darvish ,  Tami Harel ,  Bella Felsen

IPC分类号： A61N1/18

CPC分类号： A61N1/36007

摘要： A pancreatic controller, comprising: a glucose sensor, for sensing a level of glucose or insulin in a body serum; at least one electrode, for electrifying an insulin producing cell or group of cells; a power source for electrifying said electrode with a pulse that does not initiate an action potential in said cell and has an effect of increasing insulin secretion; and a controller which receives the sensed level and controls said power source to electrify said electrode to have a desired effect on said level.

公开(公告)号：US08019421B2

公开(公告)日：2011-09-13

申请号：US10237263

申请日：2002-09-05

申请人： Nissim Darvish ,  Tami Harel ,  Bella Felsen ,  Offer Glasberg

发明人： Nissim Darvish ,  Tami Harel ,  Bella Felsen ,  Offer Glasberg

IPC分类号： A61N1/05

CPC分类号： A61N1/32 ,  A61N1/05 ,  A61N1/36007

摘要： A pancreatic controller, comprising: at least one electrode adapted for electrifying at least a portion of a pancreas; and a controller programmed to electrify said electrode so as to positively control at least the effect of at least two members of a group consisting of blood glucose level, blood insulin level and blood level of another pancreatic hormone. In one example, the controller controls insulin, glucagon and/or glucose blood levels.

摘要翻译： 一种胰脏控制器，包括：至少一个电极，其适于使胰腺的至少一部分通电; 以及控制器，其被编程为使所述电极通电，以便至少主动地控制由血糖水平，血胰岛素水平和另一胰腺激素血液水平组成的组中的至少两个成员的影响。 在一个实例中，控制器控制胰岛素，胰高血糖素和/或葡萄糖血液水平。

公开(公告)号：US07006871B1

公开(公告)日：2006-02-28

申请号：US09914889

申请日：2000-03-05

申请人： Nissim Darvish ,  Tami Harel ,  Bella Felsen

发明人： Nissim Darvish ,  Tami Harel ,  Bella Felsen

IPC分类号： A61N1/18

CPC分类号： A61N1/32 ,  A61B5/14532 ,  A61B5/425 ,  A61N1/36007

摘要： A pancreatic controller (102), comprising: a glucose sensor (118), for sensing a level of glucose or insulin in a body serum; at least one electrode (110, 112), for electrifying an insulin producing cell or group of cells; a power source (104) for electrifying said electrode with a pulse that does not initiate an action potential in said cell and has an effect of increasing insulin secretion; and a controller (106) which receives the sensed level and controls said power source to electrify said electrode to have a desired effect on said level.

摘要翻译： 一种胰脏控制器（102），包括：葡萄糖传感器（118），用于感测体内血清中的葡萄糖或胰岛素水平; 至少一个电极（110,112），用于对产生胰岛素的细胞或一组细胞进行通电; 电源（104），用于以不在所述电池中引发动作电位的脉冲对所述电极充电并具有增加胰岛素分泌的作用; 以及控制器（106），其接收感测到的电平并控制所述电源以使所述电极通电以对所述电平具有期望的效果。

公开(公告)号：US20080140142A1

公开(公告)日：2008-06-12

申请号：US11933168

申请日：2007-10-31

申请人： Nissim Darvish ,  Bella Felsen ,  Itzik Shemer ,  Judith Kornfield ,  Shlomo Ben-Haim ,  Maier Fenster ,  Yuval Mika

发明人： Nissim Darvish ,  Bella Felsen ,  Itzik Shemer ,  Judith Kornfield ,  Shlomo Ben-Haim ,  Maier Fenster ,  Yuval Mika

IPC分类号： A61N1/08

CPC分类号： A61N1/3627 ,  A61N1/05 ,  A61N1/0587 ,  A61N1/36514 ,  A61N1/36564

摘要： A method of modifying the force of contraction of at least a portion of a heart chamber is provided. A non-excitatory electric field of given duration is applied, at a delay after an activation of the heart, which increase the force of contraction by at least 5%. Apparatus is also provided for pacing with hemodynamic improvement. Circuitry applies an extended pacing signal to electrodes to pace the heart, the extended pacing signal having an overall duration greater than 8 ms from a time of initiation of application of that portion of the signal that initiates action potential propagation. The signal includes a train of biphasic pulses having pulse durations of at least 1 ms, and the signal has an amplitude that is at least three times as great as a threshold for pacing the heart and that is sufficient neither for cardioversion nor for defibrillation. Other embodiments are also described.

摘要翻译： 提供了改变心室的至少一部分的收缩力的方法。 给予持续时间的非兴奋性电场在心脏激活后延迟施加，其将收缩力增加至少5％。 还提供了用于具有血液动力学改善的起搏的装置。 电路将扩展的起搏信号施加到电极以对心脏进行调节，所述扩展起搏信号的总持续时间大于从启动动作电位传播的信号部分开始施加的时间大于8ms。 该信号包括具有至少1ms的脉冲持续时间的两列脉冲，并且该信号具有至少三倍于起搏心脏阈值的幅度，并且既不适用于心脏复律也不适用于除颤。 还描述了其它实施例。

公开(公告)号：US08321013B2

公开(公告)日：2012-11-27

申请号：US11933168

申请日：2007-10-31

申请人： Nissim Darvish ,  Bella Felsen ,  Itzhak Shemer ,  Judith Kornfeld ,  Shlomo Ben-Haim ,  Maier Fenster ,  Yuval Mika

发明人： Nissim Darvish ,  Bella Felsen ,  Itzhak Shemer ,  Judith Kornfeld ,  Shlomo Ben-Haim ,  Maier Fenster ,  Yuval Mika

IPC分类号： A61N1/00

CPC分类号： A61N1/3627 ,  A61N1/05 ,  A61N1/0587 ,  A61N1/36514 ,  A61N1/36564

摘要： A method of modifying the force of contraction of at least a portion of a heart chamber is provided. A non-excitatory electric field of given duration is applied, at a delay after an activation of the heart, which increase the force of contraction by at least 5%. Apparatus is also provided for pacing with hemodynamic improvement. Circuitry applies an extended pacing signal to electrodes to pace the heart, the extended pacing signal having an overall duration greater than 8 ms from a time of initiation of application of that portion of the signal that initiates action potential propagation. The signal includes a train of biphasic pulses having pulse durations of at least 1 ms, and the signal has an amplitude that is at least three times as great as a threshold for pacing the heart and that is sufficient neither for cardioversion nor for defibrillation. Other embodiments are also described.

摘要翻译： 提供了改变心室的至少一部分的收缩力的方法。 给予持续时间的非兴奋性电场在心脏激活后延迟施加，其将收缩力增加至少5％。 还提供了用于具有血液动力学改善的起搏的装置。 电路将扩展的起搏信号施加到电极以对心脏进行调节，所述扩展起搏信号的总持续时间大于从启动动作电位传播的信号部分开始施加的时间大于8ms。 该信号包括具有至少1ms的脉冲持续时间的两列脉冲，并且该信号具有至少三倍于起搏心脏阈值的幅度，并且既不适用于心脏复律也不适用于除颤。 还描述了其它实施例。

公开(公告)号：US07460907B1

公开(公告)日：2008-12-02

申请号：US09720639

申请日：1999-07-18

申请人： Nissim Darvish ,  Bella Felsen ,  Itzik Shemer ,  Judith Kornfeld

发明人： Nissim Darvish ,  Bella Felsen ,  Itzik Shemer ,  Judith Kornfeld

IPC分类号： A61N1/362

CPC分类号： A61N1/362 ,  A61N1/3627

摘要： Apparatus (170) for heart pacing with hemodynamic improvement, including one or more electrodes (36), which convey electrical signals to respective cardiac muscle segments. Signal generation circuitry (50) applies an extended pacing signal (60, 61), having an overall duration greater than three times a chronaxie time, to the one or more electrodes so as to pace the heart. The signal preferably includes a train of a plurality of biphasic pulses, and has an amplitude at least three times as great as a threshold for pacing the heart, but not sufficient for cardioversion.

摘要翻译： 用于具有血流动力学改善的心脏起搏的装置（170），包括将电信号传送到相应心肌段的一个或多个电极（36）。 信号发生电路（50）将具有大于时间三倍的总持续时间的扩展起搏信号（60,61）施加到所述一个或多个电极，以便心跳。 信号优选地包括多个双相脉冲串，并且具有至少三倍于用于起搏心脏的阈值的振幅，但不足以用于心脏复律。

公开(公告)号：US20130018458A1

公开(公告)日：2013-01-17

申请号：US13549068

申请日：2012-07-13

申请人： Ziv Yohanan ,  Nik Gurovich ,  Bella Felsen ,  Itai Pelled ,  Oded Meiri

发明人： Ziv Yohanan ,  Nik Gurovich ,  Bella Felsen ,  Itai Pelled ,  Oded Meiri

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2436 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0065 ,  A61F2250/0069

摘要： The present disclosure is directed to embodiments of catheter-based prosthetic heart valves, and in particular, prosthetic heart valves having sealing devices configured to seal the interface between the prosthetic valve and the surrounding tissue of the native annulus in which the prosthetic valve is implanted. In one embodiment, a prosthetic heart valve includes an annular sealing member that can be placed in a delivery orientation extending axially away from one end of the valve when the valve is in a radially compressed state. When the valve is expanded, the expansion of the frame causes the sealing member to be pulled to an operative orientation covering a portion of the frame. The present disclosure also discloses new mechanisms and techniques for mounting valve leaflets to a frame of a prosthetic heart valve.

摘要翻译： 本公开涉及基于导管的假体心脏瓣膜的具体实施方式，特别地，具有密封装置的假体心脏瓣膜被配置为密封假体瓣膜和植入人造瓣膜的天然环带的周围组织之间的界面。 在一个实施例中，假体心脏瓣膜包括环形密封构件，当阀处于径向压缩状态时，环形密封构件能够沿轴向远离阀的一端延伸的排放方向放置。 当阀膨胀时，框架的膨胀使得密封构件被拉到覆盖框架的一部分的操作取向。 本公开还公开了将瓣膜瓣安装到假体心脏瓣膜的框架的新机构和技术。

公开(公告)号：US20110319991A1

公开(公告)日：2011-12-29

申请号：US13167549

申请日：2011-06-23

申请人： Ilia Hariton ,  Netanel Benichou ,  Yaacov Nitzan ,  Bella Felsen ,  Diana Nguyen-Thien-Nhon ,  Rajesh Khanna ,  Son Nguyen ,  Tamir Levi ,  Itai Pelled

发明人： Ilia Hariton ,  Netanel Benichou ,  Yaacov Nitzan ,  Bella Felsen ,  Diana Nguyen-Thien-Nhon ,  Rajesh Khanna ,  Son Nguyen ,  Tamir Levi ,  Itai Pelled

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2433 ,  A61F2/2475 ,  A61F2/95 ,  A61F2002/9522 ,  A61F2220/0033 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2230/0054 ,  Y10T29/49863

摘要： An implantable prosthetic valve, according to one embodiment, comprises a frame, a leaflet structure, and a skirt member. The frame can have a plurality of axial struts interconnected by a plurality of circumferential struts. The leaflet structure comprises a plurality of leaflets (e.g., three leaflets arrange to form a tricuspid valve). The leaflet structure has a scalloped lower edge portion secured to the frame. The skirt member can be disposed between the leaflet structure and the frame.

摘要翻译： 根据一个实施例的可植入人造瓣膜包括框架，小叶结构和裙部构件。 框架可以具有由多个圆周支柱互连的多个轴向支柱。 小叶结构包括多个传单（例如，安排形成三尖瓣的三个小叶）。 小叶结构具有固定到框架的扇形下边缘部分。 裙部构件可以设置在小叶结构和框架之间。

公开(公告)号：US08795357B2

公开(公告)日：2014-08-05

申请号：US13549068

申请日：2012-07-13

申请人： Ziv Yohanan ,  Nik Gurovich ,  Bella Felsen ,  Itai Pelled ,  Oded Meiri

发明人： Ziv Yohanan ,  Nik Gurovich ,  Bella Felsen ,  Itai Pelled ,  Oded Meiri

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2436 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0065 ,  A61F2250/0069

摘要： The present disclosure is directed to embodiments of catheter-based prosthetic heart valves, and in particular, prosthetic heart valves having sealing devices configured to seal the interface between the prosthetic valve and the surrounding tissue of the native annulus in which the prosthetic valve is implanted. In one embodiment, a prosthetic heart valve includes an annular sealing member that can be placed in a delivery orientation extending axially away from one end of the valve when the valve is in a radially compressed state. When the valve is expanded, the expansion of the frame causes the sealing member to be pulled to an operative orientation covering a portion of the frame. The present disclosure also discloses new mechanisms and techniques for mounting valve leaflets to a frame of a prosthetic heart valve.

摘要翻译： 本公开涉及基于导管的假体心脏瓣膜的具体实施方式，特别地，具有密封装置的假体心脏瓣膜被配置为密封假体瓣膜和植入人造瓣膜的天然环带的周围组织之间的界面。 在一个实施例中，假体心脏瓣膜包括环形密封构件，当阀处于径向压缩状态时，环形密封构件能够沿轴向远离阀的一端延伸的排放方向放置。 当阀膨胀时，框架的膨胀使得密封构件被拉到覆盖框架的一部分的操作取向。 本公开还公开了将瓣膜瓣安装到假体心脏瓣膜的框架的新机构和技术。