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公开(公告)号：US07501431B2
公开(公告)日：2009-03-10
申请号：US10551417
申请日：2004-03-29
申请人： Nobuaki Kushida , Naoko Watanabe , Takashi Yaguchi , Fumikazu Yokoyama , Goh Tsujiuchi , Takako Okuda
发明人： Nobuaki Kushida , Naoko Watanabe , Takashi Yaguchi , Fumikazu Yokoyama , Goh Tsujiuchi , Takako Okuda
IPC分类号： A61K31/4375 , C07D471/20
CPC分类号： C07D471/20 , C12P17/182 , C12R1/80
摘要： This invention provides novel PF1270A substance, PF1270B substance and PF1270C substance represented by the following formula (1) or pharmaceutically acceptable salts thereof, a method for producing the same and a pharmaceutical composition which comprises at least one of the same as the active ingredient. Since a group of the PF1270 substances of the invention show high affinity for histamine H3 receptor, they are expected as novel histamine H3 receptor ligands useful as medicaments.
摘要翻译： 本发明提供由下式（1）表示的新型PF1270A物质，PF1270B物质和PF1270C物质或其药学上可接受的盐，其制备方法和含有至少一种作为活性成分的药物组合物。 由于本发明的一组PF1270物质对组胺H3受体表现出高亲和力，所以它们被期望作为可用作药物的新型组胺H3受体配体。
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公开(公告)号：US20070105883A1
公开(公告)日：2007-05-10
申请号：US10551417
申请日：2004-03-29
申请人： Nobuaki Kushida , Naoko Watanabe , Takashi Yaguchi , Fumikazu Yokoyama , Goh Tsujiuchi , Takako Okuda
发明人： Nobuaki Kushida , Naoko Watanabe , Takashi Yaguchi , Fumikazu Yokoyama , Goh Tsujiuchi , Takako Okuda
IPC分类号： A61K31/4747 , C07D471/10
CPC分类号： C07D471/20 , C12P17/182 , C12R1/80
摘要： This invention provides novel PF1270A substance, PF1270B substance and PF1270C substance represented by the following formula (1) or pharmaceutically acceptable salts thereof, a method for producing the same and a pharmaceutical composition which comprises at least one of the same as the active ingredient. Since a group of the PF1270 substances of the invention show high affinity for histamine H3 receptor, they are expected as novel histamine H3 receptor ligands useful as medicaments.
摘要翻译： 本发明提供由下式（1）表示的新型PF1270A物质，PF1270B物质和PF1270C物质或其药学上可接受的盐，其制备方法和含有至少一种作为活性成分的药物组合物。 由于本发明的一组PF1270物质对组胺H 3 H 3受体表现出高亲和力，所以它们被认为是用作药物的新型组胺H 3 N 3受体配体。
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公开(公告)号：US06878535B2
公开(公告)日：2005-04-12
申请号：US10258539
申请日：2001-04-25
申请人： Takashi Yaguchi , Goh Tsujiuchi , Nobuaki Kushida , Masato Tani
发明人： Takashi Yaguchi , Goh Tsujiuchi , Nobuaki Kushida , Masato Tani
摘要： An objective of the present invention is to provide a method of producing soyasapogenol B and to provide novel microorganisms. The present invention provides a method of producing soyasapogenol B comprising the steps of culturing microorganisms that belong to genus Neocosmospora or genus Eupenicillium, in a medium containing a glycoside having soyasapogenol B as an aglycone, and then collecting soyasapogenol B from the resulting culture.
摘要翻译： 本发明的目的是提供一种生产大豆皂甙元B并提供新的微生物的方法。 本发明提供一种生产大豆皂甙元B的方法，包括以下步骤：在含有大豆皂甙元B作为糖苷配基的糖苷的培养基中培养属于新孢子虫属或青or属的微生物，然后从得到的培养物中收集大豆皂甙B.
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