公开(公告)号：US07507753B2

公开(公告)日：2009-03-24

申请号：US10499903

申请日：2002-12-26

申请人： Nobuo Cho ,  Kazuyoshi Aso ,  Satoshi Endo ,  Naoyuki Kanzaki ,  Satoshi Sasaki

发明人： Nobuo Cho ,  Kazuyoshi Aso ,  Satoshi Endo ,  Naoyuki Kanzaki ,  Satoshi Sasaki

IPC分类号： A61K31/445 ,  C07D211/58

CPC分类号： C07D401/06 ,  C07D211/58 ,  C07D401/12 ,  C07D405/06

摘要： The present invention provides a compound having melanocortin receptor agonist activity or antagonist activity, which is a novel biaryl compound represented by the formula (I): wherein ring A and ring B are optionally further substituted 6-membered aromatic rings; X is —CONR4—, —SO2NR4—, —CH2NR4— (R4 is a hydrogen atom, an optionally substituted hydrocarbon group, etc.), etc.; Y is a spacer having 1 to 12 atoms, etc.; Z is —CONR6—, —CO— (R6 is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group), etc.; R1 is an optionally substituted amino group, etc.; R2 is an optionally substituted hydrocarbon group, etc.; R3 is an optionally substituted hydrocarbon group, etc.; and R5 is an optionally substituted hydrocarbon group, etc.; or a salt thereof.

摘要翻译： 本发明提供具有黑皮质素受体激动剂活性或拮抗剂活性的化合物，其为由式（I）表示的新型联芳基化合物：其中环A和环B任选进一步被取代的6元芳环; X是-CONR 4 - ，-SO 2 NR 4 - ， - CH 2 NR 4 - （R 4是氢原子，任选取代的烃基等）等; Y为1〜12个原子的间隔基等。 Z是-CONR 6 - ，-CO-（R 6是氢原子，任选取代的烃基或任选取代的杂环基）等; R1是任选取代的氨基等; R2是任选取代的烃基等; R3是任选取代的烃基等; R5是任意取代的烃基等; 或其盐。

公开(公告)号：US20050096359A1

公开(公告)日：2005-05-05

申请号：US10499903

申请日：2002-12-26

申请人： Nobuo Cho ,  Kazuyoshi Aso ,  Satoshi Endo ,  Naoyuki Kanzaki ,  Satoshi Sasaki

发明人： Nobuo Cho ,  Kazuyoshi Aso ,  Satoshi Endo ,  Naoyuki Kanzaki ,  Satoshi Sasaki

IPC分类号： A61P1/14 ,  A61P3/04 ,  A61P15/10 ,  A61P25/00 ,  A61P29/00 ,  A61P31/18 ,  A61P43/00 ,  C07D211/58 ,  C07D401/06 ,  C07D401/12 ,  C07D405/06 ,  A61K31/44 ,  A61K31/165 ,  A61K31/40 ,  C07C233/79 ,  C07C311/45

CPC分类号： C07D401/06 ,  C07D211/58 ,  C07D401/12 ,  C07D405/06

摘要： The present invention provides a compound having melanocortin receptor agonist activity or antagonist activity, which is a novel biaryl compound represented by the formula (I): wherein ring A and ring B are optionally further substituted 6-membered aromatic rings; X is —CONR4—, —SO2NR4—, —CH2NR4— (R4 is a hydrogen atom, an optionally substituted hydrocarbon group, etc.), etc.; Y is a spacer having 1 to 12 atoms, etc.; Z is —CONR6—, —CO— (R6 is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group), etc.; R1 is an optionally substituted amino group, etc.; R2 is an optionally substituted hydrocarbon group, etc.; R3 is an optionally substituted hydrocarbon group, etc.; and R5 is an optionally substituted hydrocarbon group, etc.; or a salt thereof.

摘要翻译： 本发明提供具有黑皮质素受体激动剂活性或拮抗剂活性的化合物，其为由式（I）表示的新型联芳基化合物：其中环A和环B任选进一步被取代的6元芳环; X是-CONR 4 - ， - SO 2 NR 4 - ， - CH 2 NR 4 （R 4是氢原子，任选取代的烃基等）等; Y为1〜12个原子的间隔基等。 Z是-CONR 6，-CO-（R 6是氢原子，任选取代的烃基或任选取代的杂环基）等; R 1是任选取代的氨基等; R 2是任选取代的烃基等; R 3是任选取代的烃基等; R 5是任选取代的烃基等; 或其盐。

公开(公告)号：US20130287075A1

公开(公告)日：2013-10-31

申请号：US13977164

申请日：2011-01-27

申请人： Satoshi Endo ,  Yoshiaki Koizumi ,  Toshiyasu Higuma ,  Takuya Mukai

发明人： Satoshi Endo ,  Yoshiaki Koizumi ,  Toshiyasu Higuma ,  Takuya Mukai

IPC分类号： H04L25/02

CPC分类号： H04L25/0262 ,  H04L12/6418 ,  H04L25/05 ,  H04L25/491

摘要： A sampler samples a receive signal received via a dedicated communication line. A data transfer rate adjuster measures a data transfer rate based on a number of start bit samples contained in the receive signal. A bit determiner makes a bit determination regarding the receive signal at the data transfer rate measured by the data transfer rate adjuster, to thereby acquire serial data contained in the receive signal. A transmitter sends, via the dedicated communication line, a transmit signal containing serial data sent by an MPU. An MPU communicator outputs to the transmitter the serial data sent by the MPU, and outputs to the MPU the serial data acquired by the bit determiner. The data transfer rate adjuster adjusts, when the transmitter sends the transmit signal multiple times at different data transfer rates, the data transfer rate based on the receive status of respective response signals thereto.

摘要翻译： 采样器对通过专用通信线路接收到的接收信号进行采样。 数据传送速率调整器基于包含在接收信号中的起始比特数目的数量来测量数据传送速率。 位确定器对由数据传输速率调整器测量的数据传输速率的接收信号进行位确定，从而获取包含在接收信号中的串行数据。 发送器通过专用通信线路发送包含由MPU发送的串行数据的发送信号。 MPU通信器向MPU发送由MPU发送的串行数据，并向MPU输出由位确定器获取的串行数据。 当发送器以不同的数据传输速率多次发送发送信号时，数据传输速率调整器根据各个响应信号的接收状态来调整数据传输速率。

公开(公告)号：US07129967B2

公开(公告)日：2006-10-31

申请号：US10789997

申请日：2004-03-02

申请人： Yuichi Seki ,  Satoshi Endo ,  Atsushi Nakagawa

发明人： Yuichi Seki ,  Satoshi Endo ,  Atsushi Nakagawa

IPC分类号： B41J2/435

CPC分类号： H04N1/047

摘要： Disclosed are a frequency modulation apparatus and a frequency modulation method for generating an image clock that is used for turning on/off a laser beam that scans an image bearing member, such as a photosensitive drum. The frequency modulation apparatus divides, into a plurality of segments for each pixel, a main scan line on an image bearing member, and calculates auxiliary clock periods based on a reference clock period and variable-magnification coefficients corresponding to the segments. Then, the frequency modulation apparatus generates image clocks for the respective segments based on an initial predesignated period value and the obtained auxiliary clock periods. Furthermore, the frequency modulation apparatus includes a detecting device for detecting a difference between a reference value stored in a memory and an actual laser irradiation location, and corrects a shift in the laser irradiation location in accordance with the detection results obtained by the detecting device.

公开(公告)号：US06610655B2

公开(公告)日：2003-08-26

申请号：US09999432

申请日：2001-11-15

申请人： Mitsuhiro Wakimasu ,  Hiroshi Inooka ,  Satoshi Endo ,  Takashi Kikuchi

发明人： Mitsuhiro Wakimasu ,  Hiroshi Inooka ,  Satoshi Endo ,  Takashi Kikuchi

IPC分类号： C07K102

CPC分类号： C07K7/64 ,  A61K38/00

摘要： Cyclic pentapeptides are disclosed having the following formula (I)-Cyclo(-A1-A2-A3-A4-A5-)-wherein A1, A2, A3, A4 and A5 are amino acid residues. The pentapeptide has amino acid residues in positions 1-2-3 to form a &ggr;-turn, and amino acid residues in positions 3-4-5-1 to form a &bgr;-turn in combination with the &ggr;-turn. D-&agr;-amino acid residues are selected for A1, A3, and A5 and L-&agr;-amino acid residues are selected for A2 and A4. Compounds having &ggr;-turns and &bgr;-turns can be synthesized, regardless of the kinds of amino acid residues, and it is possible to synthesize compounds in which desired amino acid residues are introduced into sites of &bgr;-turn and &ggr;-turn based on their importance from the viewpoint of biological activity. The present invention is therefore available for design of compounds having biological activity.

摘要翻译： 公开了具有下式（I）-Cyclo（-A1-A2-A3-A4-A5-））的环五肽 - 其中A1，A2，A3，A4和A5是氨基酸残基。 五肽在1-2-3位具有氨基酸残基以形成γ-转角，并且3-4-5-1位置的氨基酸残基与γ转弯结合形成β-转角。 选择A1，A3和A5的D-α-氨基酸残基，A2和A4选择L-α-氨基酸残基。 可以合成具有γ-匝数和β-匝数的化合物，而不考虑氨基酸残基的种类，并且可以合成其中所需氨基酸残基被引入β-匝和γ-匝转位点的化合物 从生物活动的角度来看重要。 因此，本发明可用于设计具有生物活性的化合物。

公开(公告)号：US5965526A

公开(公告)日：1999-10-12

申请号：US551251

申请日：1995-10-31

申请人： Mitsuhiro Wakimasu ,  Hiroshi Inooka ,  Satoshi Endo ,  Takashi Kikuchi

发明人： Mitsuhiro Wakimasu ,  Hiroshi Inooka ,  Satoshi Endo ,  Takashi Kikuchi

IPC分类号： A61K38/00 ,  C07K1/00 ,  C07K7/64 ,  A61K38/12

CPC分类号： C07K7/64 ,  C07K1/00 ,  A61K38/00

摘要： Cyclic pentapeptides are disclosed having the following formula (I) --Cyclo(-A.sub.1 -A.sub.2 -A.sub.3 -A.sub.4 -A.sub.5 -)-- wherein A.sub.1, A.sub.2, A.sub.3, A.sub.4 and A.sub.5, are amino acid residues. The pentapeptide has amino acid residues in positions 1-2-3 to form a .gamma.-turn, and amino acid residues in positions 3-4-5-1 to form a .beta.-turn in combination with the .gamma.-turn. D-.alpha.-amino acid residues are selected for A.sub.1, A.sub.3, and A.sub.5 and L-.alpha.-amino acid residues are selected for A.sub.2 and A.sub.4. Compounds having .gamma.-turns and .beta.-turns can be synthesized, regardless of the kinds of amino acid residues, and it is possible to synthesize compounds in which desired amino acid residues are introduced into sites of .beta.-turn and .gamma.-turn based on their importance from the viewpoint of biological activity. The present invention is therefore available for design of compounds having biological activity.

摘要翻译： 公开了具有下式（I）-Cyclo（-A1-A2-A3-A4-A5-））的环五肽，其中A1，A2，A3，A4和A5是氨基酸残基。 五肽在1-2-3位具有氨基酸残基以形成γ转角，并且3-4-5-1位置的氨基酸残基与γ转角组合形成β转角。 A1，A3和A5选择D-α-氨基酸残基，A2和A4选择L-氨基酸残基。 可以合成具有γ-转角和β-转角的化合物，而不管氨基酸残基的种类如何，并且可以合成其中所需氨基酸残基被引入β-转角和γ转角的位点的化合物，基于它们 从生物活动的角度来看重要。 因此，本发明可用于设计具有生物活性的化合物。

公开(公告)号：US5838411A

公开(公告)日：1998-11-17

申请号：US988234

申请日：1997-12-10

申请人： Kouji Hayakawa ,  Satoshi Endo ,  Hisashi Yoshida ,  Noboru Hoshino ,  Masayoshi Fujieda

发明人： Kouji Hayakawa ,  Satoshi Endo ,  Hisashi Yoshida ,  Noboru Hoshino ,  Masayoshi Fujieda

IPC分类号： G02F1/133 ,  G02F1/1333 ,  G02F1/1335 ,  G02F1/1343

CPC分类号： G02F1/134336 ,  G02F1/133512 ,  G02F2001/133388

摘要： A liquid crystal display device includes a liquid crystal display panel. The liquid crystal display panel includes a first transparent substrate having color filters arranged in a predetermined order, a patterned light blocking film formed between the color filters and first transparent electrodes formed on the color filters; a second transparent substrate having second transparent electrodes arranged to intersect the first transparent electrodes; a liquid crystal layer sandwiched between the first and second transparent substrates with the first and second transparent electrodes opposing each other and spacers dispersed between the first and second transparent substrates. The color filters and the light blocking film extend into a marginal area outside an area optically switchable upon application of an electric field on the liquid crystal display panel in substantially the same geometric pattern as within the optically switchable area. A plurality of dummy electrodes can also be formed in the marginal area on at least one of the first and second substrates, so as to oppose the transparent electrodes on the opposite substrate. The extension of the color filters and the light blocking film into a marginal area and the disposition of the dummy electrodes in the marginal area can be applied in one liquid crystal display panel, singly or in combination.

摘要翻译： 液晶显示装置包括液晶显示面板。 液晶显示面板包括具有以预定顺序布置的滤色器的第一透明基板，形成在滤色器和形成在滤色器上的第一透明电极之间的图案遮光膜; 第二透明基板，具有布置成与第一透明电极相交的第二透明电极; 夹在第一和第二透明基板之间的液晶层，其中第一和第二透明电极彼此相对，分隔在第一和第二透明基板之间。 滤色器和遮光膜延伸到在可与光可切换区域基本相同的几何图案中的在液晶显示面板上施加电场之后可光学切换的区域中的边缘区域。 多个虚拟电极也可以形成在第一和第二基板中的至少一个上的边缘区域中，以与相对基板上的透明电极相对。 将滤色器和遮光膜延伸到边缘区域中，并且虚拟电极在边缘区域中的布置可以单独地或组合地应用于一个液晶显示面板。

公开(公告)号：US10281495B2

公开(公告)日：2019-05-07

申请号：US14401724

申请日：2012-06-14

申请人： Satoshi Endo ,  Yoshiaki Koizumi ,  Takuya Mukai

发明人： Satoshi Endo ,  Yoshiaki Koizumi ,  Takuya Mukai

IPC分类号： G01R13/02 ,  G01R19/165 ,  H04L12/26 ,  H04L29/14

摘要： A switcher transmits, to an extractor/signal determiner, a converted current signal generated by a current-voltage converter when a converted current signal determiner determines that the converted current signal is generated by transmission of a current signal over a communication line, in the meantime, performs a switch-over so as not to transmit, to the extractor/signal determiner, a converted voltage signal generated by a voltage sensor. In addition, the switcher transmits, to the extractor/signal determiner, the converted voltage signal when a converted voltage signal determiner determines that the converted voltage signal is generated by transmission of a voltage signal over a communication line, in the meantime, performs a switch-over so as not to transmit, to the extractor/signal determiner, the converted current signal generated by the current-voltage converter.

公开(公告)号：US09557359B2

公开(公告)日：2017-01-31

申请号：US14765198

申请日：2013-02-14

申请人： Masahiro Ishihara ,  Satoshi Endo ,  Yoshiaki Koizumi ,  Shinsaku Kusube ,  Masaki Takata ,  Yoshihiro Taniguchi

发明人： Masahiro Ishihara ,  Satoshi Endo ,  Yoshiaki Koizumi ,  Shinsaku Kusube ,  Masaki Takata ,  Yoshihiro Taniguchi

IPC分类号： G01R19/00 ,  G01R25/00 ,  G01R29/18 ,  G01R15/18 ,  G01R31/02

CPC分类号： G01R25/005 ,  G01R15/142 ,  G01R15/18 ,  G01R29/18 ,  G01R31/02

摘要： A voltage/current verifier computes, for each phase, a phase difference between phase voltage and phase current from the phase of phase voltage and the phase of phase current computed for each phase by a phase acquirer, and determines conformity if all of the computed phase differences are within a preset range. A current/current verifier computes phase differences between phase currents from the phase of phase current computed for each phase by the phase acquirer, and determines conformity if all of the computed phase differences are less than 180°. A reporting device reports that a current transformer is incorrectly placed on a power line unless both the voltage/current verifier and the current/current verifier do not determine conformity.

摘要翻译： 电压/电流验证器针对每相进行相位电压与相电流相位之间的相位差，以及由相位获取器为每相计算的相电流相位，并且如果所有计算相位 差异在预设范围内。 电流/电流验证器根据相位获取器计算每相的相电流相位之间的相位差，并且如果所计算出的所有相位差都小于180°，则确定其一致性。 报告设备报告说，电流互感器不正确放置在电源线上，除非电压/电流验证器和当前/当前验证器都不确定一致性。

公开(公告)号：US20100035511A1

公开(公告)日：2010-02-11

申请号：US12461076

申请日：2009-07-30

申请人： Satoshi Endo

发明人： Satoshi Endo

IPC分类号： A63H18/00

CPC分类号： A63H19/15 ,  A63H17/05

摘要： The present invention is directed to improving the reality of a model container car that imitates the form of a real car.The vehicle main body 2 has a plurality of mounting holes 2b provided side by side along a vehicle length X, and opposed to one another along a vehicle width Y on a loading surface on which a container is mounted. The mounting member 5A is removably mounted on the mounting hole 2b. The mounting member 5A includes a upper engagement portion and a lower engagement portion. The lower engagement portion is provided within an insertion area inserted into the mounting hole 2b and engageable with the vehicle main body 2. The lower engagement portion is provided above the insertion area and engageable with an inner side surface of the container 4A.

摘要翻译： 本发明旨在改进模仿真实轿厢形式的模型集装箱车的现实。 车辆主体2具有沿着车辆长度X并列设置的多个安装孔2b，并且在安装容器的装载面上沿车宽Y彼此相对。 安装构件5A可拆卸地安装在安装孔2b上。 安装构件5A包括上接合部和下接合部。 下部接合部设置在插入安装孔2b的插入区域中并与车辆主体2接合。下部接合部设置在插入区域上方并与容器4A的内侧面接合。