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公开(公告)号：US07667006B2
公开(公告)日：2010-02-23
申请号：US10582861
申请日：2004-03-09
CPC分类号： C07K16/1063 , C07K2317/76 , C07K2317/92 , G01N2333/16
摘要： The present invention aims at providing a high affinity anti-HIV antibody. According to the present invention, there are provided an antibody or a fragment thereof that binds to the gp12 glycoprotein of HIV and has a dissociation constant (KD) value of 1.0×10−9 (M) or less; a pharmaceutical composition comprising the antibody or fragment thereof; and a method of producing an anti-HIV antibody or a fragment thereof, comprising immunizing a GANP transgenic non-human mammal or a progeny thereof with a polypeptide consisting of the amino acid sequence as shown in SEQ ID NO: 6 as an antigen and collecting the antibody from the resultant mammal or progeny.
摘要翻译： 本发明旨在提供高亲和力的抗HIV抗体。 根据本发明，提供了与HIV的gp12糖蛋白结合并具有1.0×10-9（M）以下的解离常数（KD）值的抗体或其片段; 包含抗体或其片段的药物组合物; 以及产生抗HIV抗体或其片段的方法，包括用由SEQ ID NO：6所示的氨基酸序列组成的多肽免疫GANP转基因非人哺乳动物或其后代作为抗原并收集 来自所得哺乳动物或后代的抗体。
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公开(公告)号：US20080050365A1
公开(公告)日：2008-02-28
申请号：US10582861
申请日：2004-03-09
CPC分类号： C07K16/1063 , C07K2317/76 , C07K2317/92 , G01N2333/16
摘要： The present invention aims at providing a high affinity anti-HIV antibody. According to the present invention, there are provided an antibody or a fragment thereof that binds to the gp12 glycoprotein of HIV and has a dissociation constant (KD) value of 1.0×10−9 (M) or less; a pharmaceutical composition comprising the antibody or fragment thereof; and a method of producing an anti-HIV antibody or a fragment thereof, comprising immunizing a GANP transgenic non-human mammal or a progeny thereof with a polypeptide consisting of the amino acid sequence as shown in SEQ ID NO: 6 as an antigen and collecting the antibody from the resultant mammal or progeny
摘要翻译： 本发明旨在提供高亲和力的抗HIV抗体。 根据本发明，提供了结合HIV的gp12糖蛋白的抗体或其片段，其解离常数（KD）为1.0×10 -9（M）以下; 包含抗体或其片段的药物组合物; 以及产生抗HIV抗体或其片段的方法，包括用由SEQ ID NO：6所示的氨基酸序列组成的多肽免疫GANP转基因非人哺乳动物或其后代作为抗原并收集 来自所得哺乳动物或后代的抗体
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3.发明申请公开(公告)号：US20060166297A1
公开(公告)日：2006-07-27
申请号：US11263355
申请日：2005-10-31
申请人： Yusei Nagase , Shingo Shinagawa , Masao Kawakita , Kyoko Hiramatsu , Mika Ito , Yosuke Mizukami , Chiemi Minoda
发明人： Yusei Nagase , Shingo Shinagawa , Masao Kawakita , Kyoko Hiramatsu , Mika Ito , Yosuke Mizukami , Chiemi Minoda
IPC分类号： G01N33/537 , C07K16/00 , C12N5/16 , C12N5/06
CPC分类号： C07K16/30 , G01N33/57488
摘要： The present invention provides an anti-diacetylspermine specific monoclonal antibody which satisfies a specific measuring condition in an immunoreaction system between a solid-phased diacetylspermine and the anti-diacetylspermine specific monoclonal antibody, wherein the immunoreaction system comprises a sample diacetylspermine or sample N1-acetylspermidine to inhibit the immunoreaction; and the specific measuring condition is that the 50% inhibition activity against the immunoreaction by the diacetylspermine in the sample is at least 1,000 times as much as the 50% inhibition activity against the immunoreaction by the N1-acetylspermidine in the sample.
摘要翻译： 本发明提供一种抗二乙酰精胺特异性单克隆抗体，其在固相二乙酰精胺与抗二乙酰精胺特异性单克隆抗体之间的免疫反应系统中满足特定测定条件，其中免疫反应系统包含样品二乙酰精胺或样品N 1'-乙酰亚精胺抑制免疫反应; 具体的测定条件是，对于样品中的二乙酰精胺的免疫反应的50％抑制活性是抗N0 - 乙酰亚胺的免疫反应的50％抑制活性的至少1000倍 在样品中。
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4.发明申请公开(公告)号：US20100093006A1
公开(公告)日：2010-04-15
申请号：US12578322
申请日：2009-10-13
申请人： Yusei Nagase , Shingo Shinagawa , Masao Kawakita , Kyoko Hiramatsu , Mika Ito , Yosuke Mizukami , Chiemi Minoda
发明人： Yusei Nagase , Shingo Shinagawa , Masao Kawakita , Kyoko Hiramatsu , Mika Ito , Yosuke Mizukami , Chiemi Minoda
IPC分类号： G01N33/537 , C07K16/00 , C12N5/16
CPC分类号： C07K16/30 , G01N33/57488
摘要： The present invention provides an anti-diacetylspermine specific monoclonal antibody which satisfies a specific measuring condition in an immunoreaction system between a solid-phased diacetylspermine and the anti-diacetylspermine specific monoclonal antibody, wherein the immunoreaction system comprises a sample diacetylspermine or sample N1-acetylspermidine to inhibit the immunoreaction; and the specific measuring condition is that the 50% inhibition activity against the immunoreaction by the diacetylspermine in the sample is at least 1,000 times as much as the 50% inhibition activity against the immunoreaction by the N1-acetylspermidine in the sample.
摘要翻译： 本发明提供一种抗二乙酰精胺特异性单克隆抗体，其在固相化二乙酰精胺与抗二乙酰精胺特异性单克隆抗体之间的免疫反应系统中满足特定测定条件，其中免疫反应系统包含样品二乙酰精胺或样品N1-乙酰精胺 抑制免疫反应; 具体的测定条件是样品中二乙酰精胺的免疫反应的50％抑制活性至少为抗N1样品中N1-乙酰精胺的免疫反应的50％抑制活性的1000倍。
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公开(公告)号：US07700741B2
公开(公告)日：2010-04-20
申请号：US11263355
申请日：2005-10-31
申请人： Yusei Nagase , Shingo Shinagawa , Masao Kawakita , Kyoko Hiramatsu , Mika Ito , Yosuke Mizukami , Chiemi Minoda
发明人： Yusei Nagase , Shingo Shinagawa , Masao Kawakita , Kyoko Hiramatsu , Mika Ito , Yosuke Mizukami , Chiemi Minoda
IPC分类号： C12N15/02
CPC分类号： C07K16/30 , G01N33/57488
摘要： The present invention provides an anti-diacetylspermine specific monoclonal antibody which satisfies a specific measuring condition in an immunoreaction system between a solid-phased diacetylspermine and the anti-diacetylspermine specific monoclonal antibody, wherein the immunoreaction system comprises a sample diacetylspermine or sample N1-acetylspermidine to inhibit the immunoreaction; and the specific measuring condition is that the 50% inhibition activity against the immunoreaction by the diacetylspermine in the sample is at least 1,000 times as much as the 50% inhibition activity against the immunoreaction by the N1-acetylspermidine in the sample.
摘要翻译： 本发明提供一种抗二乙酰精胺特异性单克隆抗体，其在固相化二乙酰精胺与抗二乙酰精胺特异性单克隆抗体之间的免疫反应系统中满足特定测定条件，其中免疫反应系统包含样品二乙酰精胺或样品N1-乙酰精胺 抑制免疫反应; 具体的测定条件是样品中二乙酰精胺的免疫反应的50％抑制活性至少为抗N1样品中N1-乙酰精胺的免疫反应的50％抑制活性的1000倍。
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