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公开(公告)号：US20130142812A1
公开(公告)日：2013-06-06
申请号：US13701947
申请日：2011-06-03
IPC分类号： C07K16/30 , A61K39/395
CPC分类号： C07K16/30 , A61K39/39558 , C07K16/2863 , C07K2317/73
摘要： A cell growth inhibitor that includes, as an antibody component, an artificially produced anti-EGFR antibody having specific binding capacity to EGFR which is characterized in that an epitope therefor is in a cysteine-rich subdomain 2 (C2 domain) and/or in a ligand-binding domain 1 (L1 domain) among four subdomains contained in the extracellular domain of EGFR.
摘要翻译： 作为抗体成分的细胞生长抑制剂，其特征在于，其表位为富含半胱氨酸的亚结构域2（C2结构域）和/或 配体结合域1（L1结构域）在包含在EGFR细胞外结构域的四个子结构域之间。
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公开(公告)号：US09029513B2
公开(公告)日：2015-05-12
申请号：US13701947
申请日：2011-06-03
IPC分类号： C07K16/30 , A61K39/395 , C07K16/28
CPC分类号： C07K16/30 , A61K39/39558 , C07K16/2863 , C07K2317/73
摘要： A cell growth inhibitor that includes, as an antibody component, an artificially produced anti-EGFR antibody having specific binding capacity to EGFR which is characterized in that an epitope therefor is in a cysteine-rich subdomain 2 (C2 domain) and/or in a ligand-binding domain 1 (L1 domain) among four subdomains contained in the extracellular domain of EGFR.
摘要翻译： 作为抗体成分的细胞生长抑制剂，其特征在于，其表位为富含半胱氨酸的亚结构域2（C2结构域）和/或 配体结合域1（L1结构域）在包含在EGFR细胞外结构域的四个子结构域之间。
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公开(公告)号：US08603967B2
公开(公告)日：2013-12-10
申请号：US13386539
申请日：2010-07-28
申请人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa
发明人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa
CPC分类号： C07K7/08 , A61K47/6455 , C07K2319/10 , C12N2710/14143
摘要： A method for transferring a foreign substance includes the steps of: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including either the amino acid sequence KKRTLRKNDRKKR (SEQ ID NO. 1) or an amino acid sequence formed by the substitution, deletion, and/or addition (insertion) of 1, 2, or 3 amino acid residues in the amino acid sequence, and a foreign substance of interest that is bonded to the N-terminus and/or C-terminus of the carrier peptide fragment; supplying the construct for transferring a foreign substance to a test sample that contains a target eukaryotic cell; and incubating the test sample that has been supplied with the construct for transferring a foreign substance to thereby transfer the construct into the eukaryotic cell in the test sample.
摘要翻译： 用于转移异物的方法包括以下步骤：制备用于转移含有包含氨基酸序列KKRTLRKNDRKKR（SEQ ID NO.1）或由该取代形成的氨基酸序列的载体肽片段的异物的构建体， 缺失和/或添加（插入）氨基酸序列中的1,2或3个氨基酸残基，以及与载体肽片段的N末端和/或C末端键合的目标异源 ; 提供用于将异物转移到含有目标真核细胞的测试样品的构建体; 并将已经提供的用于转移异物的构建物的测试样品孵育，从而将构建体转移到测试样品中的真核细胞中。
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公开(公告)号：US20090253618A1
公开(公告)日：2009-10-08
申请号：US11996207
申请日：2006-07-20
CPC分类号： C07K14/4703 , A61K38/00
摘要： A neuronal differentiation inducer comprising at least one peptide which can induce the differentiation of at least one cell into a neurocyte. The peptide is an artificially synthesized peptide comprising an amino acid sequence derived from a BC-box of at least one protein belonging to the SOCS protein family or an amino acid sequence having a partial modification in the BC-box-derived amino acid sequence, wherein the BC-box-derived amino acid sequence is composed of at least 10 contiguous amino acid residues selected in the amino acid sequence constituting the BC-box.
摘要翻译： 一种神经元分化诱导剂，其包含至少一种能诱导至少一种细胞分化为神经细胞的肽。 肽是人造合成的肽，其包含衍生自属于SOCS蛋白家族的至少一种蛋白质的BC盒的氨基酸序列或在BC-盒衍生的氨基酸序列中具有部分修饰的氨基酸序列，其中 BC盒衍生的氨基酸序列由在构成BC盒的氨基酸序列中选择的至少10个连续氨基酸残基组成。
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公开(公告)号：US20060089488A1
公开(公告)日：2006-04-27
申请号：US11247376
申请日：2005-10-11
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/16122
摘要： Artificially synthesized antimicrobial peptide that does not occur naturally is provided by the present invention. The antimicrobial peptide includes one unit, two units or more units of amino acid sequence composed of the following 8 amino acid residues: (R or Q)-(L or F or I)—I—K-(L or F or I or V)-L-Y-Q; and/or, modified sequence composed of said sequence with partial modification.
摘要翻译： 人造合成的天然不发生的抗微生物肽由本发明提供。 抗微生物肽包括由以下8个氨基酸残基组成的一个单元，两个单元或更多个氨基酸序列单元：<？in-line-formula description =“In-line Formulas”end =“lead”？>（R或 Q） - （L或F或I）-IK-（L或F或I或V）-LYQ; 和/或由所述序列组成的经修改的修改序列。
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公开(公告)号：US08710005B2
公开(公告)日：2014-04-29
申请号：US13258788
申请日：2010-04-12
IPC分类号： A61K38/16 , C07K14/435
CPC分类号： C07K14/4756 , A61K38/00
摘要： A neuronal differentiation inducer provided by the present invention contains an artificially synthesized peptide which includes an amino acid sequence constituting a signal peptide in amyloid precursor protein (APP), or a partial sequence of the amino acid sequence constituting this signal peptide.
摘要翻译： 本发明提供的神经元分化诱导剂含有人造合成的肽，其包含构成该淀粉状蛋白前体蛋白（APP）中的信号肽的氨基酸序列或构成该信号肽的氨基酸序列的部分序列。
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7.发明申请公开(公告)号：US20140072592A1
公开(公告)日：2014-03-13
申请号：US13978419
申请日：2012-01-06
IPC分类号： G01N33/68 , C07K16/18 , C07K14/705 , C07K14/47 , C07K14/245 , C07K16/12 , C07K16/28
CPC分类号： G01N33/6896 , C07K14/245 , C07K14/4711 , C07K14/70596 , C07K16/1232 , C07K16/18 , C07K16/2896
摘要： The object of the present invention is to provide a method to obtain an antibody for a hydrophobic peptide, which can be used for general purposes easily and with great reliability. Also provided is a method for preparing an antigen characterized in that a hydrophobic peptide, which is unbound to carrier protein, is used as high-molecular-weight aggregates in an aqueous solution containing a nonionic surfactant.
摘要翻译： 本发明的目的是提供一种获得疏水性肽抗体的方法，其可以容易且高可靠性地用于一般目的。 还提供了制备抗原的方法，其特征在于将未结合载体蛋白的疏水性肽用作含有非离子表面活性剂的水溶液中的高分子量聚集体。
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公开(公告)号：US08019803B2
公开(公告)日：2011-09-13
申请号：US11664990
申请日：2005-10-13
申请人： Mitsuo Eguchi , Tetsuhiko Yoshida
发明人： Mitsuo Eguchi , Tetsuhiko Yoshida
IPC分类号： G06F17/10
CPC分类号： G06T5/10 , G06T5/003 , G06T2207/30176
摘要： The present invention provides a technology which can perform a precise restoration to a distribution of original information by carrying out an iterative calculation using only a distribution of degraded information. The method according to the present invention performs the restoration to original information based only on degraded information. The method according to the present invention considers the distribution of the degraded information and the distribution of the original information as distributions of probability density functions, and considers a transfer function of a transfer system as a probability density function of a conditional probability. The most probable estimations of the distribution of the original information with respect to the distribution of the degraded information and the most probable estimations of the distribution of the transfer function are alternately carried out to finally restore the original information by means of the iterative calculation based on the Bayes' theorem for probability density functions.
摘要翻译： 本发明提供一种技术，其可以通过仅使用劣化信息的分布进行迭代计算，来对原始信息的分布进行精确的恢复。 根据本发明的方法仅基于退化的信息执行对原始信息的恢复。 根据本发明的方法将劣化信息的分布和原始信息的分布视为概率密度函数的分布，并将转移系统的传递函数视为条件概率的概率密度函数。 相对于劣化信息的分布和最可能的传递函数分布的估计，原始信息的分布的最可能的估计被交替地执行，以通过基于以下的迭代计算来最终恢复原始信息： 贝叶斯定理的概率密度函数。
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公开(公告)号：US20060122122A1
公开(公告)日：2006-06-08
申请号：US11294583
申请日：2005-12-05
IPC分类号： A61K38/08
摘要： Antimicrobial agent including an artificially synthesized antimicrobial peptide that does not occur naturally is provided by present invention. The peptide included in the antimicrobial agent includes 1 unit, 2 units or more units of sequence(s) or sequence(s) with partial modification, the sequence(s) composed of at least 6 contiguous amino acid residues selected from any one of amino acid sequences: (a)KVQIINKK; (b)SVQIVYKP; (c)QVEVKSEK; (d)KKVAVVRT; (e)KKVAIIRT; (f)KKPTSAK, and the total number of amino acid residues included in 1 unit, 2 units or more units of sequence(s) is 30% or more of the total number of amino acid residues constituting the peptide chain.
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公开(公告)号：US06907393B1
公开(公告)日：2005-06-14
申请号：US10110242
申请日：2000-10-12
申请人： Tetsuhiko Yoshida
发明人： Tetsuhiko Yoshida
CPC分类号： C12N15/1089
摘要： The present invention provides methods for selecting artificial promotor candidates that reduce the number of promotors required to be evaluated by actual experimentation when designing artificial promotor candidates that are potentially effective for structural genes. In these artificial promotor candidate selection methods, a randomly selected nucleotide sequence is joined upstream of a structural gene (S1). Next, nucleotides are extracted in a predetermined pattern from a designated region containing at least the transcription start site of the joined nucleotide sequence, thereby generating a virtual amino acid sequence, and an index curve is generated from the virtual amino acid sequence (S2, S3). Then, the nucleotide sequence joined upstream of the structural gene is selected as an artificial promotor candidate if the index curve exhibits a sign change near the transcription start site (S4).
摘要翻译： 本发明提供了当设计对结构基因潜在有效的人工启动子候选物时，选择人工启动子候选物的方法，所述人工启动子候选物通过实际实验减少需要评估的启动子数目。 在这些人工启动子候选选择方法中，将随机选择的核苷酸序列连接到结构基因的上游（S1）。 接下来，从包含连接的核苷酸序列的至少转录起始位点的指定区域以规定的图案提取核苷酸，从而生成虚拟氨基酸序列，从虚拟氨基酸序列生成指标曲线（S 2， S 3）。 然后，如果索引曲线在转录起始位点附近表现出符号变化，则选择连接在结构基因上游的核苷酸序列作为人工启动子候选物（S 4）。
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