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公开(公告)号：US5735105A
公开(公告)日：1998-04-07
申请号：US481411
申请日：1995-10-02
CPC分类号： A61J3/07 , Y10S264/37 , Y10S425/804 , Y10T156/109
摘要： A continuous solvent free gelatin encapsulation apparatus and process includes an oil roll back assembly (20) for applying a controlled amount of a food-approved lubricant to a first side of the gelatin ribbon and an applicator guide bar assembly (40) for applying a controlled amount of food-approved lubricant to a second side of the gelatin ribbon. Two opposing food-approved lubricant coated gelatin ribbons are then united in a die assembly (50) to form gelatin capsules which are then dried and recovered.
摘要翻译： PCT No.PCT / GB93 / 02566 Sec。 371 1995年10月2日日期 102（e）日期1995年10月2日PCT 1993年12月16日PCT公布。 公开号WO94 / 13249 日期1994年6月23日一种连续无溶剂的明胶包封装置和方法包括用于将明显的胶带的第一面施加受控量的食品认可的润滑剂的油卷回装置（20）和涂抹器导杆组件（40） ），用于将受控量的食品认可的润滑剂施加到明胶带的第二侧。 然后将两个相对食物认可的润滑剂涂覆的明胶带合并在模具组件（50）中以形成明胶胶囊，然后将其干燥并回收。
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公开(公告)号：US5380534A
公开(公告)日：1995-01-10
申请号：US164629
申请日：1993-12-09
CPC分类号： A61J1/067
摘要： Knurled surfaces such as raised ribs are provided on the shell of a soft gelatin capsule in order to enhance gripping and manipulation of the capsule. The capsule has a removable tab at one end thereof which may also be provided with a knurled surface. One embodiment of the invention is a capsule used for delivery of medicaments to an external body surface. An alternative embodiment of the capsule is disclosed for insertion into a body orifice. The composition of the capsule includes a starch or starch derivative which gives the capsule a drier feel and increases the coefficient of friction of the surface of the shell, further improving the capsule's handling characteristics.
摘要翻译： 在软明胶胶囊的外壳上提供诸如凸肋的滚花表面，以增强胶囊的夹持和操纵。 胶囊在其一端具有可移除的突片，其也可以设置有滚花表面。 本发明的一个实施方案是用于将药物输送到外部身体表面的胶囊。 公开了胶囊的替代实施例用于插入体孔中。 胶囊的组成包括淀粉或淀粉衍生物，其给予胶囊更干燥的感觉并增加壳表面的摩擦系数，进一步改善胶囊的处理特性。
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公开(公告)号：US5670159A
公开(公告)日：1997-09-23
申请号：US368749
申请日：1995-01-04
IPC分类号： A61K8/00 , A61K8/11 , A61K9/48 , A61L9/04 , A61Q13/00 , B01J13/04 , C08L83/04 , C08L89/00 , C11B9/00
CPC分类号： A61Q13/00 , A61K8/11 , A61K9/4825 , A61K9/4858 , A61K9/4866 , Y10S514/962
摘要： Fragrances in soft gelatin capsules are disclosed. The desired fragrance is dissolved in a solvent system comprising a volatile solvent, a non-volatile cosolvent, or a combination of a volatile solvent and a non-volatile cosolvent or cosolvents. The resulting solution is then encapsulated by soft gelatin shell prepared with an odor-free, glycerol free gelatin plasticized with a partially dehydrated, hydrogenated glucose syrup.
摘要翻译： 公开了软明胶胶囊中的香料。 所需的香料溶解在包含挥发性溶剂，非挥发性助溶剂或挥发性溶剂和非挥发性共溶剂或助溶剂的组合的溶剂体系中。 然后将所得溶液用由无味的无甘油游离明胶制备的软明胶壳包封，该明胶用部分脱水的氢化葡萄糖浆增塑。
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公开(公告)号：US5614217A
公开(公告)日：1997-03-25
申请号：US482775
申请日：1995-06-07
IPC分类号： A61K9/48
CPC分类号： A61K9/4825 , A61K9/4816 , Y10S514/962
摘要： A gelatin capsule that is generally resistant to humidity having a non-hygroscopic plasticizer and an elasticity reducing gelatin extender in the formulation of the gelatin capsule shell. The capsule is capable of being manufactured on conventional rotary die encapsulation devices and can readily hold liquid fill materials. The capsule is breakable with manual pressure.
摘要翻译： 在明胶胶囊壳的制剂中，通常具有耐湿性的明胶胶囊具有不吸湿增塑剂和弹性降低的明胶延长剂。 胶囊能够在传统的旋转模头封装装置上制造，并且可以容易地保持液体填充材料。 胶囊易手动压力。
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公开(公告)号：US5484598A
公开(公告)日：1996-01-16
申请号：US313423
申请日：1994-09-27
CPC分类号： A61J1/067
摘要： Knurled surfaces such as raised ribs are provided on the shell of a soft gelatin capsule in order to enhance gripping and manipulation of the capsule. The capsule has a removable tab at one end thereof which may also be provided with a knurled surface. One embodiment of the invention is a capsule used for delivery of medicaments to an external body surface. An alternative embodiment of the capsule is disclosed for insertion into a body orifice. The composition of the capsule includes a starch or starch derivative which gives the capsule a drier feel and increases the coefficient of friction of the surface of the shell, further improving the capsule's handling characteristics.
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公开(公告)号：US08377470B2
公开(公告)日：2013-02-19
申请号：US13543244
申请日：2012-07-06
IPC分类号： A61K9/48
CPC分类号： A61K9/4816
摘要： A non-gelatin encapsulation system for liquid filled soft capsules, by nature of the carrier, the cationic-ionic balance of the carrier and the active ingredients, or the concentration of the active ingredients and excipients, are difficult or impossible to commercially encapsulate in gelatin capsules. In particular, the system is adapted for the encapsulation of highly basic, or alkaline, fills. The system provides for a predominantly starch and gelling carrageenan based shell, which displays high resistance to both concentrated fills and to alkaline fills, in particular, to those fills which contain the salt or salts of weak acids and strong bases.
摘要翻译： 用于液体填充的软胶囊的非明胶包封系统，由载体的性质，载体的阳离子离子平衡和活性成分，或活性成分和赋形剂的浓度，难以或不可能商业地包封在明胶中 胶囊。 特别地，该系统适用于高度碱性或碱性填料的包封。 该系统主要提供淀粉和胶凝角叉菜胶基壳，其显示出对浓缩填充物和碱性填料的高抗性，特别是含有弱酸和强碱的盐或盐的填料。
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公开(公告)号：US20120269889A1
公开(公告)日：2012-10-25
申请号：US13543244
申请日：2012-07-06
IPC分类号： A61K9/48 , A61K31/192 , A61K31/167
CPC分类号： A61K9/4816
摘要： A non-gelatin encapsulation system for liquid filled soft capsules, by nature of the carrier, the cationic-ionic balance of the carrier and the active ingredients, or the concentration of the active ingredients and excipients, are difficult or impossible to commercially encapsulate in gelatin capsules. In particular, the system is adapted for the encapsulation of highly basic, or alkaline, fills. The system provides for a predominantly starch and gelling carrageenan based shell, which displays high resistance to both concentrated fills and to alkaline fills, in particular, to those fills which contain the salt or salts of weak acids and strong bases.
摘要翻译： 用于液体填充的软胶囊的非明胶包封系统，由载体的性质，载体的阳离子离子平衡和活性成分，或活性成分和赋形剂的浓度，难以或不可能商业地包封在明胶中 胶囊。 特别地，该系统适用于高度碱性或碱性填料的包封。 该系统主要提供淀粉和胶凝角叉菜胶基壳，其显示出对浓缩填充物和碱性填料的高抗性，特别是含有弱酸和强碱的盐或盐的填料。
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公开(公告)号：US08231896B2
公开(公告)日：2012-07-31
申请号：US10984205
申请日：2004-11-08
IPC分类号： A61K9/48
CPC分类号： A61K9/4816
摘要： A non-gelatin encapsulation system for liquid filled soft capsules, by nature of the carrier, the cationic-ionic balance of the carrier and the active ingredients, or the concentration of the active ingredients and excipients, are difficult or impossible to commercially encapsulate in gelatin capsules. In particular, the system is adapted for the encapsulation of highly basic, or alkaline, fills. The system provides for a predominantly starch and gelling carrageenan based shell, which displays high resistance to both concentrated fills and to alkaline fills, in particular, to those fills which contain the salt or salts of weak acids and strong bases.
摘要翻译： 用于液体填充的软胶囊的非明胶包封系统，由载体的性质，载体的阳离子离子平衡和活性成分，或活性成分和赋形剂的浓度，难以或不可能商业地包封在明胶中 胶囊。 特别地，该系统适用于高度碱性或碱性填料的包封。 该系统主要提供淀粉和胶凝角叉菜胶基壳，其显示出对浓缩填充物和碱性填料的高抗性，特别是含有弱酸和强碱的盐或盐的填料。
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公开(公告)号：US06099858A
公开(公告)日：2000-08-08
申请号：US935401
申请日：1997-09-23
IPC分类号： A61K8/00 , A61K8/11 , A61K9/48 , A61L9/04 , A61Q13/00 , B01J13/04 , C08L83/04 , C08L89/00 , C11B9/00 , A61K9/50
CPC分类号： A61Q13/00 , A61K8/11 , A61K9/4825 , A61K9/4858 , A61K9/4866 , Y10S514/962
摘要： Methods for preparing soft gelatin capsules containing fragrances are disclosed. The desired fragrance is dissolved in a solvent system comprising a volatile solvent, a non-volatile cosolvent, or a combination of a volatile solvent and a non-volatile cosolvent or cosolvents. The resulting mixture is then encapsulated between gelatin ribbions prepared with an odor-free gelatin plasticized with a partially dehydrated, hydrogenated glucose syrup.
摘要翻译： 公开了制备含有香料的软明胶胶囊的方法。 所需的香料溶解在包含挥发性溶剂，非挥发性助溶剂或挥发性溶剂和非挥发性共溶剂或助溶剂的组合的溶剂体系中。 然后将所得混合物包封在用无气味明胶塑化的部分脱水，氢化葡萄糖浆制成的明胶肋之间。
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