公开(公告)号：US06303104B1

公开(公告)日：2001-10-16

申请号：US09249295

申请日：1999-02-12

申请人： Anthony E. Winston ,  Jordan Barth ,  Norman Usen

发明人： Anthony E. Winston ,  Jordan Barth ,  Norman Usen

IPC分类号： A61K716

CPC分类号： A61Q11/00 ,  A61K8/19 ,  A61K8/24 ,  A61K2800/88

摘要： An oral product, preferably a toothpaste, effective for remineralizing subsurface dental lesions, mineralizing exposed dentinal tubules and whitening teeth stained with discoloring residues containing heavy metal ions such as Fe+3, Mn+2 and Cu+2, is composed of a first discrete part composed of a water-soluble or partially water-soluble calcium salt and optionally a non-toxic, non-calcium water-soluble divalent metal salt, and a second discrete part composed of a water-soluble orthophosphate salt and preferably a water-soluble fluoride salt. Further enhanced stain-removing properties without excessive abrasivity are imparted to the oral product when part (A) further contains an effective amount of an anhydrous dicalcium phosphate abrasive and part (B) further contains an effective amount of a silica abrasive.

摘要翻译： 用于再矿化地下牙齿病变，矿化暴露的牙质小管和由含有重金属离子如Fe + 3，Mn + 2和Cu + 2的变色残渣染色的美白牙齿的口服产品，优选牙膏由第一离散 由水溶性或部分水溶性钙盐和任选的无毒非钙水溶性二价金属盐组成的部分，以及由水溶性正磷酸盐组成的第二离散部分，优选水溶性 氟化盐。 当部分（A）还含有有效量的无水磷酸二钙研磨剂时，口腔产品也能赋予进一步增强的除污性能，而不会过度磨损，部分（B）还含有有效量的二氧化硅磨料。

公开(公告)号：US6036944A

公开(公告)日：2000-03-14

申请号：US301364

申请日：1999-04-29

申请人： Anthony E. Winston ,  Norman Usen

发明人： Anthony E. Winston ,  Norman Usen

IPC分类号： A61K8/24 ,  A61Q11/00 ,  A61K7/16

CPC分类号： A61Q11/00 ,  A61K8/24 ,  A61K2800/88

摘要： A method for remineralizing one or more subsurface lesions in a tooth and/or mineralizing one or more exposed dentinal tubules in the tooth involves dispensing effective amounts of at least one water-soluble calcium salt, at least one water-soluble non-toxic divalent metal compound wherein the divalent metal is other than calcium, at least one water-soluble phosphate salt and, optionally, a water-soluble fluoride salt; mixing the salts and compound to form a non-carbonated mixture having a pH in water such that a non-carbonated aqueous solution containing the mixture has a pH of from 4.5 to about 7.0; and then applying the non-carbonated mixture as the non-carbonated aqueous solution to a surface of the tooth for a sufficient period of time to allow sufficient amounts of calcium, phosphate and, if present, fluoride, ions in the solution to diffuse into the subsurface of the tooth where the diffused ions then react to form an insoluble precipitate onto the lesions and/or exposed tubules, thereby remineralizing the lesions and/or mineralizing the tubules.

摘要翻译： 一种用于再牙合牙齿中的一个或多个地下损伤和/或矿化牙齿中的一个或多个暴露的牙质小管的方法包括分配有效量的至少一种水溶性钙盐，至少一种水溶性无毒二价金属 化合物，其中二价金属不是钙，至少一种水溶性磷酸盐和任选的水溶性氟化物盐; 混合盐和化合物以形成具有在水中的pH的非碳酸化混合物，使得含有该混合物的非碳酸化水溶液的pH为4.5至约7.0; 然后将非碳酸化混合物作为非碳酸化的水溶液施加到牙齿的表面足够长的时间以允许足够量的钙，磷酸盐和（如果存在的话）溶液中的氟离子扩散到 然后扩散的离子然后反应以在病变和/或暴露的小管上形成不溶性沉淀物，从而使病变再矿化和/或使小管矿化。

公开(公告)号：US5895641A

公开(公告)日：1999-04-20

申请号：US670897

申请日：1996-06-26

申请人： Norman Usen ,  Anthony E. Winston

发明人： Norman Usen ,  Anthony E. Winston

IPC分类号： A61K8/21 ,  A61K8/24 ,  A61Q11/00 ,  A61K7/16 ,  A61K7/18

CPC分类号： A61Q11/00 ,  A61K8/21 ,  A61K8/24 ,  A61K2800/88

摘要： The present invention relates to the problems of remineralization without demineralization of dental enamel by applying to the teeth a composition which is present in two phases which do not react with one another until introduced into the oral cavity. One phase contains at least one water-soluble calcium compound and the other contains at least one water-soluble inorganic phosphate and at least one water-soluble fluorine compound. In this way the ions which effect remineralization can be absorbed by the dental enamel and their subsequent reaction causes rehardening of demineralized areas in the dental enamel.

摘要翻译： 本发明涉及通过向牙齿施用不同于相互反应直至引入口腔的两相中的组合物而使牙釉质没有软化的再矿化的问题。 一相含有至少一种水溶性钙化合物，另一种含有至少一种水溶性无机磷酸盐和至少一种水溶性氟化合物。 以这种方式，可以通过牙釉质吸收影响再矿化的离子，并且随后的反应引起牙釉质中软化区域的再固化。

公开(公告)号：US5571502A

公开(公告)日：1996-11-05

申请号：US512287

申请日：1995-08-08

申请人： Anthony E. Winston ,  Norman Usen

发明人： Anthony E. Winston ,  Norman Usen

IPC分类号： A61K8/00 ,  A61K8/19 ,  A61K8/21 ,  A61K8/24 ,  A61Q11/00 ,  A61K7/16 ,  A61K7/18 ,  A61K33/16

CPC分类号： A61Q11/00 ,  A61K8/19 ,  A61K8/24

摘要： This invention relates to non-aqueous compositions and methods utilizing same which are useful to remineralize subsurface dental enamel. More specifically, this invention relates to stable, single-part compositions containing calcium and phosphate salts which may be in a hydrophilic, non-aqueous vehicle and which when applied to lesions in dental enamel result in remineralization of subsurface dental enamel and/or mineralization of tubules in dentin thereby counteracting caries and/or hypersensitivity.

公开(公告)号：US4740366A

公开(公告)日：1988-04-26

申请号：US820694

申请日：1986-01-21

申请人： Anthony E. Winston ,  Raymond S. Brown ,  Frederick W. Lawson ,  Norman Usen

发明人： Anthony E. Winston ,  Raymond S. Brown ,  Frederick W. Lawson ,  Norman Usen

IPC分类号： A61L9/01 ,  A61L9/14 ,  A61L9/04

CPC分类号： A61L9/01 ,  A61L9/14

摘要： An air deodorizer, and a method for deodorizing rooms therewith, utilizing an aerosol of a solution containing from 2-25% by weight of non-toxic, non-oxidizing, deodorizing agent, said solution constituting liquid droplets having a weight average droplet size of less than 50 microns, more than 90% of said droplets having a size, by count, of less than 10 microns.

摘要翻译： 空气除臭剂及其室内除臭方法，利用含有2-25％（重量）无毒非氧化性除臭剂的溶液气溶胶，所述溶液构成液滴重均粒径为 小于50微米，超过90％的所述液滴具有小于10微米的尺寸。

公开(公告)号：US06482395B1

公开(公告)日：2002-11-19

申请号：US10137317

申请日：2002-05-03

申请人： Jordan Barth ,  Anthony E. Winston ,  Norman Usen

发明人： Jordan Barth ,  Anthony E. Winston ,  Norman Usen

IPC分类号： A61K968

CPC分类号： A61Q11/00 ,  A61K8/19 ,  A61K8/24 ,  A61K2800/88

摘要： A solid oral product, e.g., chewing gum, lozenge, an edible foodstuff, and the like, which is useful for remineralizing subsurface dental lesions and/or mineralizing exposed dentinal tubules, contains (A) a discrete cationic agglomerate component composed of at least one water-soluble or partially water-soluble calcium salt and a first inert solid carrier, and (B) a discrete anionic agglomerate component composed of at least one water-soluble orthophosphate salt and a second inert solid carrier. The agglomerate nature of the cationic and anionic components keeps these components separate from one another during storage of the product but allows the cationic and anionic salts to be simultaneously released from the product upon mixing of the product with water and/or saliva to form a mixed aqueous solution such that the solution contains both calcium cations released from the calcium salt and orthophosphate anions released by the orthophosphate salt.

摘要翻译： 可用于再矿化地下牙齿损伤和/或矿化暴露的牙质小管的固体口服产品，例如口香糖，锭剂，食用食品等，其包含（A）由至少一个 水溶性或部分水溶性钙盐和第一惰性固体载体，和（B）由至少一种水溶性正磷酸盐和第二惰性固体载体组成的离散的阴离子附聚物组分。 阳离子和阴离子组分的聚集性质使这些组分在产物储存期间彼此分离，但是当产品与水和/或唾液混合时，允许阳离子和阴离子盐同时从产物中释放，以形成混合 水溶液使得溶液含有从钙盐释放的钙阳离子和由正磷酸盐释放的正磷酸盐阴离子。

公开(公告)号：US06451290B2

公开(公告)日：2002-09-17

申请号：US09884354

申请日：2001-06-20

申请人： Anthony E. Winston ,  Norman Usen

发明人： Anthony E. Winston ,  Norman Usen

IPC分类号： A61K968

CPC分类号： A61Q11/00 ,  A61K8/19 ,  A61K8/24 ,  A61K2800/88

摘要： Improved solid products for remineralizing subsurface lesions and/or mineralizing exposed tubules in dentin contain an anionic component, a cationic component and a separating component for separating the anionic and cationic components in the product. The anionic component contains at least one water-soluble phosphate salt and the cationic component contains at least one partially water-soluble calcium salt. To remineralize subsurface lesions and/or mineralize exposed dentin tubules in a tooth, the anionic and cationic components are mixed with water and/or saliva to form a mixed aqueous composition having a pH of from greater than about 4.0 to about 10.0, which is then applied to the tooth. Because of the partial water-solubility of the calcium salt, the calcium cations and the phosphate anions in the mixed aqueous composition remain soluble for a period of time sufficient to allow the cations and anions to diffuse through the surface of the tooth to the subsurface and/or dentin, where the diffused cations and anions react to form an insoluble precipitate on the lesion for remineralization thereof and/or on the exposed tubule for mineralization thereof. The products may be in the form of chewing gums, lozenges, candies, edible food products, and the like.

摘要翻译： 用于再矿化地下病变和/或矿化牙本质中暴露的小管的改进的固体产品含有阴离子组分，阳离子组分和用于分离产物中阴离子和阳离子组分的分离组分。 阴离子组分含有至少一种水溶性磷酸盐，阳离子组分含有至少一种部分水溶性钙盐。 为了再次矿化地下损伤和/或使牙齿中暴露的牙质小管矿化，将阴离子和阳离子组分与水和/或唾液混合以形成具有大于约4.0至约10.0的pH的混合水性组合物 适用于牙齿。 由于钙盐的部分水溶性，混合水性组合物中的钙阳离子和磷酸盐阴离子保持溶解一段时间，足以允许阳离子和阴离子通过牙齿的表面扩散到地下， /或牙本质，其中扩散的阳离子和阴离子反应以在病变上形成不溶性沉淀物，用于再矿化和/或暴露的小管以使其矿化。 产品可以是口香糖，锭剂，糖果，食用食品等的形式。

公开(公告)号：US06440394B2

公开(公告)日：2002-08-27

申请号：US09893019

申请日：2001-06-26

申请人： Jordan Barth ,  Anthony E. Winston ,  Norman Usen

发明人： Jordan Barth ,  Anthony E. Winston ,  Norman Usen

IPC分类号： A61K916

CPC分类号： A61Q11/00 ,  A61K8/19 ,  A61K8/24 ,  A61K2800/88

摘要： A solid oral product, e.g., chewing gum, lozenge, an edible foodstuff, and the like, which is useful for remineralizing subsurface dental lesions and/or mineralizing exposed dentinal tubules, contains (A) a discrete cationic agglomerate component composed of at least one water-soluble or partially water-soluble calcium salt and a first inert solid carrier, and (B) a discrete anionic agglomerate component composed of at least one water-soluble orthophosphate salt and a second inert solid carrier. The agglomerate nature of the cationic and anionic components keeps these components separate from one another during storage of the product but allows the cationic and anionic salts to be simultaneously released from the product upon mixing of the product with water and/or saliva to form a mixed aqueous solution such that the solution contains both calcium cations released from the calcium salt and orthophosphate anions released by the orthophosphate salt.

公开(公告)号：US6159448A

公开(公告)日：2000-12-12

申请号：US722457

申请日：1996-09-27

申请人： Anthony E. Winston ,  Norman Usen

发明人： Anthony E. Winston ,  Norman Usen

IPC分类号： A61K8/19 ,  A61K8/21 ,  A61K8/23 ,  A61K8/24 ,  A61K8/36 ,  A61K8/362 ,  A61K8/365 ,  A61K8/86 ,  A61Q11/00 ,  A61K7/16 ,  A61K7/18

CPC分类号： A61Q11/00 ,  A61K8/19 ,  A61K8/21 ,  A61K8/24 ,  A61K2800/88

摘要： Improved one-part and two-part liquid products such as, e.g., mouthwashes, mouthrinses, toothpastes, gels and the like, for remineralizing subsurface lesions and/or mineralizing exposed dentin tubules in teeth contain a cationic component, an anionic component and a separating means for separating the cationic and anionic components. The anionic component contains water-soluble phosphate and fluoride salts, while the cationic component contains at least one partially water-soluble calcium salt and preferably at least one water-soluble salt of a divalent metal other than calcium. The tooth is treated with a mixed aqueous composition formed by mixing the cationic and anionic components with water and/or saliva. The mixed aqueous composition has a pH of from about 4.0 to about 10.0 and, in addition to dissolved calcium cations and dissolved phosphate and fluoride anions, contains a quantity of undissolved calcium salt. The use of the partially water-soluble calcium salt delays precipitation of the cations and anions in the aqueous composition until after the ions have diffused through the tooth surface to the subsurface and/or dentin so as to effect remineralization and/or mineralization, respectively.

公开(公告)号：US5958380A

公开(公告)日：1999-09-28

申请号：US888623

申请日：1997-07-07

申请人： Anthony E. Winston ,  Norman Usen

发明人： Anthony E. Winston ,  Norman Usen

IPC分类号： A61K8/19 ,  A61K8/24 ,  A61K8/34 ,  A61K8/365 ,  A61K9/68 ,  A61Q11/00 ,  A61K7/16

CPC分类号： A61Q11/00 ,  A61K8/19 ,  A61K8/24 ,  A61K8/345 ,  A61K8/365 ,  A61K9/0058

摘要： This invention relates to a stable, single-part chewing gum product and methods of using same to effect remineralization of subsurface lesions in teeth and/or mineralization of exposed dentinal tubules. The chewing gum product contains a water-soluble cationic portion, a water-soluble anionic portion and a stabilizing component which substantially inhibits reaction between the cationic and anionic portions during storage of the chewing gum product but which allows the cationic and anionic portions to be simultaneously released at a substantially equal rate from the product when the product is chewed in the presence of saliva and/or water. The cationic portion is composed of at least one water-soluble calcium salt, and the anionic portion contains at least one water-soluble phosphate and, optionally, at least one water-soluble fluoride salt. The stabilizing component may be at least one water-soluble divalent metal salt other than calcium salt, the divalent metal salt being disposed in the cationic portion of the product. Alternatively, the stabilizing component may be a desiccating agent or an encapsulating coating, wherein the encapsulating coating is disposed on particles of one or both of the cationic and anionic portions.

摘要翻译： 本发明涉及稳定的单一部分口香糖产品及其使用方法来实现牙齿中的地下损伤的再矿化和/或暴露的牙质小管的矿化。 口香糖产品含有水溶性阳离子部分，水溶性阴离子部分和稳定成分，其在口香糖产品储存期间基本上抑制阳离子部分和阴离子部分之间的反应，但是允许阳离子部分和阴离子部分同时 当产品在唾液和/或水的存在下咀嚼时，以与产品基本上相同的速率释放。 阳离子部分由至少一种水溶性钙盐组成，阴离子部分含有至少一种水溶性磷酸盐和任选的至少一种水溶性氟化物盐。 稳定成分可以是除钙盐以外的至少一种水溶性二价金属盐，二价金属盐配置在产物的阳离子部分。 或者，稳定组分可以是干燥剂或包封涂层，其中包封涂层设置在阳离子部分和阴离子部分中的一个或两个的颗粒上。