公开(公告)号：US20170058336A1

公开(公告)日：2017-03-02

申请号：US15119859

申请日：2015-02-23

申请人： Northeastern University

发明人： Audrey IVANKIN ,  Joseph LARKIN ,  Robert HENLEY ,  Meni WANUNU

IPC分类号： C12Q1/68 ,  G01N21/64

CPC分类号： C12Q1/6869 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6458 ,  G01N33/48721 ,  G01N2021/6439 ,  G01N2021/7786 ,  C12Q2521/543 ,  C12Q2563/137 ,  C12Q2565/631

摘要： Described herein are systems for analysis of biopolymers and complexes containing biopolymers based on optical measurement of ion flux through pores. Also described are methods of using such devices for analysis of biopolymers and complexes containing biopolymers, including methods of determining the nucleotide sequences of polynucleotides.

摘要翻译： 本文描述的是用于分析基于通过孔的离子通量的光学测量的含有生物聚合物的生物聚合物和络合物的系统。 还描述了使用这种装置来分析含有生物聚合物的生物聚合物和复合物的方法，包括确定多核苷酸的核苷酸序列的方法。

公开(公告)号：US20180135118A1

公开(公告)日：2018-05-17

申请号：US15572296

申请日：2016-05-11

申请人： Northeastern University

发明人： Meni WANUNU ,  Joseph LARKIN ,  Robert HENLEY

IPC分类号： C12Q1/6869 ,  B82Y20/00 ,  G02B6/10

CPC分类号： C12Q1/6869 ,  B82Y20/00 ,  G02B6/107 ,  C12Q2535/122 ,  C12Q2563/107 ,  C12Q2565/601 ,  C12Q2565/631

摘要： Devices and methods useful for sequencing and characterizing single nucleic acid molecules involve large arrays of nanopore zero-mode waveguides (NZMWs). The methods and devices are made possible by fabrication of nanoporous membranes of appropriate porosity for use in nucleotide sequencing. The fabrication methods eliminate the need for serial nanopore formation and make possible the mass production of highly efficient DNA and RNA single molecule sequencing devices.