公开(公告)号：US20200173041A1

公开(公告)日：2020-06-04

申请号：US16781486

申请日：2020-02-04

申请人： Northeastern University

发明人： Pradeep WADUGE ,  Swastik KAR ,  Meni WANUNU ,  Joseph LARKIN ,  Ismail BILGIN

IPC分类号： C25B9/10 ,  G01N33/487 ,  C01B32/186 ,  C12Q1/6869 ,  G01N27/447

摘要： The invention provides methods for direct growth of low noise, atomically thin freestanding membranes of two-dimensional monocrystalline or polycrystalline materials, such as transition metal chalcogenides including molybdenum disulfide. The freestanding membranes are directly grown over an aperture by reacting two precursors in a chemical vapor deposition process carried out at atmospheric pressure. Membrane growth is preferentially over apertures in a thin sheet of solid state material. The resulting membranes are one or a few atomic layers thick and essentially free of defects. The membranes are useful for sequencing of biopolymers through nanopores.

公开(公告)号：US20170058336A1

公开(公告)日：2017-03-02

申请号：US15119859

申请日：2015-02-23

申请人： Northeastern University

发明人： Audrey IVANKIN ,  Joseph LARKIN ,  Robert HENLEY ,  Meni WANUNU

IPC分类号： C12Q1/68 ,  G01N21/64

CPC分类号： C12Q1/6869 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6458 ,  G01N33/48721 ,  G01N2021/6439 ,  G01N2021/7786 ,  C12Q2521/543 ,  C12Q2563/137 ,  C12Q2565/631

摘要： Described herein are systems for analysis of biopolymers and complexes containing biopolymers based on optical measurement of ion flux through pores. Also described are methods of using such devices for analysis of biopolymers and complexes containing biopolymers, including methods of determining the nucleotide sequences of polynucleotides.

摘要翻译： 本文描述的是用于分析基于通过孔的离子通量的光学测量的含有生物聚合物的生物聚合物和络合物的系统。 还描述了使用这种装置来分析含有生物聚合物的生物聚合物和复合物的方法，包括确定多核苷酸的核苷酸序列的方法。

公开(公告)号：US20180135118A1

公开(公告)日：2018-05-17

申请号：US15572296

申请日：2016-05-11

申请人： Northeastern University

发明人： Meni WANUNU ,  Joseph LARKIN ,  Robert HENLEY

IPC分类号： C12Q1/6869 ,  B82Y20/00 ,  G02B6/10

CPC分类号： C12Q1/6869 ,  B82Y20/00 ,  G02B6/107 ,  C12Q2535/122 ,  C12Q2563/107 ,  C12Q2565/601 ,  C12Q2565/631

摘要： Devices and methods useful for sequencing and characterizing single nucleic acid molecules involve large arrays of nanopore zero-mode waveguides (NZMWs). The methods and devices are made possible by fabrication of nanoporous membranes of appropriate porosity for use in nucleotide sequencing. The fabrication methods eliminate the need for serial nanopore formation and make possible the mass production of highly efficient DNA and RNA single molecule sequencing devices.

公开(公告)号：US20210302410A1

公开(公告)日：2021-09-30

申请号：US17344035

申请日：2021-06-10

申请人： Northeastern University

发明人： Pradeep WADUGE ,  Joseph LARKIN ,  Moneesh UPMANYU ,  Swastik KAR ,  Meni WANUNU

IPC分类号： G01N33/487 ,  C23C16/26 ,  C23C16/56 ,  C23C16/02 ,  C01B32/186 ,  C12Q1/6869 ,  G01N27/447

摘要： Described herein are devices containing freestanding, ultrathin (

公开(公告)号：US20180038001A1

公开(公告)日：2018-02-08

申请号：US15552373

申请日：2015-11-25

申请人： Northeastern University

发明人： Pradeep WADUGE ,  Swastik KAR ,  Meni WANUNU ,  Joseph LARKIN ,  Ismail BILGIN

IPC分类号： C25B9/10 ,  C12Q1/68 ,  C01B32/186 ,  G01N33/487 ,  G01N27/447

CPC分类号： C25B9/10 ,  C01B32/186 ,  C12Q1/6869 ,  G01N27/4473 ,  G01N27/44791 ,  G01N33/48721

摘要： The invention provides methods for direct growth of low noise, atomically thin freestanding membranes of two-dimensional monocrystalline or polycrystalline materials, such as transition metal chalcogenides including molybdenum disulfide. The freestanding membranes are directly grown over an aperture by reacting two precursors in a chemical vapor deposition process carried out at atmospheric pressure. Membrane growth is preferentially over apertures in a thin sheet of solid state material. The resulting membranes are one or a few atomic layers thick and essentially free of defects. The membranes are useful for sequencing of biopolymers through nanopores.