公开(公告)号：US20240199591A1

公开(公告)日：2024-06-20

申请号：US18392203

申请日：2023-12-21

申请人： Northeastern University ,  Indiana University Research and Technology Corporation

发明人： Ganeshsingh A. THAKUR ,  Diomedes E. LOGOTHETIS ,  Lucas CANTWELL ,  Yu XU ,  Anantha SHEKHAR

IPC分类号： C07D409/12 ,  A61K31/415 ,  A61P25/22 ,  C07D231/40 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

CPC分类号： C07D409/12 ,  A61K31/415 ,  A61P25/22 ,  C07D231/40 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

摘要： Selective small molecule regulators of GIRK potassium channels are provided, which are effective in treatment of post-traumatic stress disorder and other medical conditions.

公开(公告)号：US20210355084A1

公开(公告)日：2021-11-18

申请号：US17054056

申请日：2019-06-26

申请人： Northeastern University

发明人： Ganeshsingh A. THAKUR ,  Sumanta GARAI

IPC分类号： C07D209/12 ,  C07D209/18 ,  C07D401/04 ,  C07D417/04 ,  C07D409/04 ,  C07D403/06 ,  A61P27/06

摘要： Heteroaromatic compounds are provided which are allosteric modulators of the cannabinoid receptors and which are useful for the treatment of glaucoma, pain, neuropathic pain, post-traumatic stress disorder (PTSD), and neurodegenerative diseases such as Huntington's disease, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and other diseases where cannabinoid receptors are involved.

公开(公告)号：US20170217984A1

公开(公告)日：2017-08-03

申请号：US15328112

申请日：2015-07-23

申请人： Northeastern University ,  University of Florida Research Foundation, Inc.

发明人： Ganeshsingh A. THAKUR ,  Abhijit R. KULKARNI ,  Roger Lee PAPKE

IPC分类号： C07D495/04 ,  C07D401/04 ,  C07D491/048 ,  C07D405/04 ,  C07D409/10 ,  C07D401/12 ,  C07D401/10 ,  C07D417/04 ,  C07D409/14 ,  C07D221/16 ,  C07D409/04

CPC分类号： C07D495/04 ,  C07D221/16 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D405/04 ,  C07D409/04 ,  C07D409/10 ,  C07D409/14 ,  C07D417/04 ,  C07D491/048

摘要： Compounds are provided which bind to an allosteric site on the mammalian alpha-7 nicotinic acetylcholine receptor (alpha-7 nAChR) and act as positive allosteric modulators with or without allosteric agonist activity. The compounds are useful in diagnosing, preventing, or treating a variety of disorders involving cognition, learning, memory, neurodegeneration, drug addiction, inflammation, chronic pain, and neuropathic pain. The compounds also can be used to enhance memory and learning in normal individuals.

公开(公告)号：US20170197918A1

公开(公告)日：2017-07-13

申请号：US15416311

申请日：2017-01-26

申请人： Northeastern University

发明人： Ganeshsingh A. THAKUR ,  Pushkar M. KULKARNI

IPC分类号： C07D209/10 ,  C07D401/06 ,  C07D401/10

CPC分类号： C07D209/10 ,  C07D209/14 ,  C07D401/06 ,  C07D401/10

摘要： The present invention relates to novel heterocyclic derivatives which are allosteric modulators of cannabinoid receptor 1 (CB1) and which are useful for the treatment or prevention of neurological and psychiatric disorders associated with endocannabinoid dysfunction and diseases in which the CB1 subtype of cannabinoid receptor is involved; to processes for their preparation; to pharmaceutical compositions comprising them; and to methods of using them.

公开(公告)号：US20150005346A1

公开(公告)日：2015-01-01

申请号：US14323492

申请日：2014-07-03

申请人： Northeastern University

发明人： Ganeshsingh A. THAKUR ,  Pushkar M. KULKARNI

IPC分类号： C07D209/10 ,  C07D401/06

CPC分类号： C07D209/10 ,  C07D209/14 ,  C07D401/06 ,  C07D401/10

摘要： The present invention relates to novel heterocyclic derivatives which are allosteric modulators of cannabinoid receptor 1 (CB1) and which are useful for the treatment or prevention of neurological and psychiatric disorders associated with endocannabinoid dysfunction and diseases in which the CB1 subtype of cannabinoid receptor is involved; to processes for their preparation; to pharmaceutical compositions comprising them; and to methods of using them.

摘要翻译： 本发明涉及新型杂环衍生物，其为大麻素受体1（CB1）的变构调节剂，其可用于治疗或预防与大麻素受体相关的内源性大麻素功能障碍的神经和精神疾病以及涉及其的CB1亚型的疾病; 进行准备; 包含它们的药物组合物; 以及使用它们的方法。