公开(公告)号：US10307415B2

公开(公告)日：2019-06-04

申请号：US15618715

申请日：2017-06-09

申请人： Northwestern University ,  The Wistar Institute of Anatomy and Biology

发明人： Phillip B. Messersmith ,  Iossif A. Strehin ,  Ellen Heber-Katz

IPC分类号： A61K31/4745 ,  C12N9/02 ,  C08G65/333 ,  C08G65/332 ,  C08G65/334 ,  A61K47/60

摘要： Methods and compositions are described for enhancing tissue regeneration or wound repair in a mammalian subject comprising a composition comprising (a) a proline hydroxylase inhibitor component or molecule that increases or upregulates HIF1a and (b) a carrier component comprising a hydrogel.

公开(公告)号：US20190381031A1

公开(公告)日：2019-12-19

申请号：US16429822

申请日：2019-06-03

申请人： Northwestern University ,  The Wistar Institute of Anatomy and Biology

发明人： Phillip B. Messersmith ,  Iossif A. Strehin ,  Ellen Heber-Katz

IPC分类号： A61K31/4745 ,  C08G65/333 ,  C12N9/02 ,  C08G65/332 ,  C08G65/334 ,  A61K47/60

摘要： Methods and compositions are described for enhancing tissue regeneration or wound repair in a mammalian subject comprising a composition comprising (a) a proline hydroxylase inhibitor component or molecule that increases or upregulates HIF1a and (b) a carrier component comprising a hydrogel.

公开(公告)号：US11033541B2

公开(公告)日：2021-06-15

申请号：US16429822

申请日：2019-06-03

申请人： Northwestern University ,  The Wistar Institute of Anatomy and Biology

发明人： Phillip B. Messersmith ,  Iossif A. Strehin ,  Ellen Heber-Katz

IPC分类号： A61K31/4745 ,  C08G65/333 ,  C12N9/02 ,  C08G65/332 ,  C08G65/334 ,  A61K47/60

摘要： Methods and compositions are described for enhancing tissue regeneration or wound repair in a mammalian subject comprising a composition comprising (a) a proline hydroxylase inhibitor component or molecule that increases or upregulates HIF1a and (b) a carrier component comprising a hydrogel.

公开(公告)号：US09675607B2

公开(公告)日：2017-06-13

申请号：US14544003

申请日：2014-11-13

申请人： Northwestern University ,  The Wistar Institute of Anatomy and Biology

发明人： Phillip B. Messersmith ,  Iossif A. Strehin ,  Ellen Heber-Katz

IPC分类号： A61K47/48 ,  A61K31/4745 ,  C12N9/02 ,  C08G65/333

CPC分类号： A61K31/4745 ,  A61K47/48215 ,  A61K47/48784 ,  A61K47/60 ,  C08G65/332 ,  C08G65/333 ,  C08G65/33331 ,  C08G65/33337 ,  C08G65/33396 ,  C08G65/3342 ,  C08G65/3344 ,  C08G65/3348 ,  C08G2210/00 ,  C08G2650/32 ,  C08G2650/58 ,  C08L2203/02 ,  C12N9/0071 ,  C12Y114/11002

摘要： Methods and compositions are described for enhancing tissue regeneration or wound repair in a mammalian subject comprising a composition comprising (a) a proline hydroxylase inhibitor component or molecule that increases or upregulates HIF1a and (b) a carrier component comprising a hydrogel.