公开(公告)号：US20210323947A1

公开(公告)日：2021-10-21

申请号：US17235120

申请日：2021-04-20

Applicant: Novartis AG ,  Katholieke Universiteit Leuven ,  Korea Research Institute of Chemical Technology

Inventor： Johan NEYTS ,  Daniel POON ,  Keith Bruce PFISTER

IPC: C07D405/12 ,  C07D405/14 ,  C07D307/93 ,  A61K45/06 ,  A61P31/14

Abstract: The invention provides compounds of Formula (I): as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections.

公开(公告)号：US20250090491A1

公开(公告)日：2025-03-20

申请号：US18797480

申请日：2024-08-07

Applicant: Novartis AG ,  Katholieke Universiteit Leuven ,  Korea Research Institute of Chemical Technology

Inventor： Johan NEYTS ,  Daniel POON ,  Keith Bruce PFISTER ,  Young-Sik JUNG ,  Soo Bong HAN ,  Yashwardhan R. MALPANI ,  Prashant CHAKRASALI ,  Sang-Ho LEE ,  Chong-Kyo LEE ,  Chonsaeng KIM ,  Jin Soo SHIN ,  Hae Soo KIM

IPC: A61K31/343 ,  A61P31/14 ,  C07D307/93

Abstract: This disclosure provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections.

公开(公告)号：US20210322362A1

公开(公告)日：2021-10-21

申请号：US17235140

申请日：2021-04-20

Applicant: Novartis AG ,  Katholieke Universiteit Leuven ,  Korea Research Institute of Chemical Technology

Inventor： Johan NEYTS ,  Daniel POON ,  Keith Bruce PFISTER

IPC: A61K31/343 ,  C07D307/93 ,  A61P31/14

Abstract: This disclosure provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections.

公开(公告)号：US20250011334A1

公开(公告)日：2025-01-09

申请号：US18743020

申请日：2024-06-13

Applicant: Novartis AG

Inventor： Rama JAIN ,  Dennis Christofer KOESTER ,  James R. MANNING ,  Vanessa MARX ,  Daniel POON ,  James Clifford SUTTON ,  Benjamin R. TAFT ,  Lifeng WAN ,  Aregahegn YIFRU ,  Qian ZHAO

IPC: C07D487/14 ,  A61K31/5025 ,  A61K31/53 ,  A61K31/5365 ,  A61K31/5383 ,  A61K31/551 ,  A61P31/16 ,  C07D471/14 ,  C07D498/14

Abstract: The invention provides compounds of Formula (1): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.

公开(公告)号：US20190247392A1

公开(公告)日：2019-08-15

申请号：US16210968

申请日：2018-12-05

Applicant: Novartis AG

Inventor： Jeffrey T. BAGDANOFF ,  Yu DING ,  Wooseok HAN ,  Zilin HUANG ,  Qun JIANG ,  Xianming JIN ,  Xiang KOU ,  Patrick LEE ,  Mika LINDVALL ,  Zhongcheng MIN ,  Yue PAN ,  Sabina PECCHI ,  Keith Bruce PFISTER ,  Daniel POON ,  Vivek RAUNIYAR ,  Xiaojing Michael WANG ,  Qiong ZHANG ,  Jianguang ZHOU ,  Shejin ZHU

IPC: A61K31/497 ,  A61K31/5355 ,  A61K31/4436 ,  A61K31/4433 ,  A61K31/44 ,  C07D403/06 ,  C07D401/12 ,  C07D401/06 ,  C07D213/73 ,  C07D413/14 ,  C07D241/20 ,  C07D401/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D498/04 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/4965 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/553 ,  A61K45/06

Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.

公开(公告)号：US20180057501A1

公开(公告)日：2018-03-01

申请号：US15686652

申请日：2017-08-25

Applicant: Novartis AG

Inventor： Rama JAIN ,  Dennis Christofer KOESTER ,  James R. MANNING ,  Vanessa MARX ,  Daniel POON ,  James Clifford SUTTON ,  Benjamin R. TAFT ,  Lifeng WAN ,  Aregahegn YIFRU ,  Qian ZHAO

IPC: C07D487/14 ,  C07D498/14 ,  C07D471/14

CPC classification number: C07D487/14 ,  C07D471/14 ,  C07D498/14

Abstract: The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.

公开(公告)号：US20180028532A1

公开(公告)日：2018-02-01

申请号：US15672568

申请日：2017-08-09

Applicant: Novartis AG

Inventor： Jeffrey T. BAGDANOFF ,  Yu DING ,  Wooseok HAN ,  Zilin HUANG ,  Qun JIANG ,  Xianming JIN ,  Xiang KOU ,  Patrick LEE ,  Mika LINDVALL ,  Zhongcheng MIN ,  Yue PAN ,  Sabina PECCHI ,  Keith Bruce PFISTER ,  Daniel POON ,  Vivek RAUNIYAR ,  Xiaojing Michael WANG ,  Qiong ZHANG ,  Jianguang ZHOU ,  Shejin ZHU

IPC: A61K31/497 ,  A61K31/4433 ,  A61K31/5355 ,  A61K31/44 ,  A61K31/4436

CPC classification number: A61K31/497 ,  A61K31/44 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/4965 ,  A61K31/506 ,  A61K31/5355 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/553 ,  A61K45/06 ,  A61K2121/00 ,  C07D213/73 ,  C07D241/20 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D413/14 ,  C07D498/04

Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.