公开(公告)号：US20170240548A1

公开(公告)日：2017-08-24

申请号：US15435137

申请日：2017-02-16

Applicant: Novartis AG

Inventor： Jiping FU ,  Xianming JIN ,  Patrick LEE ,  Peichao LU ,  Joseph Michael YOUNG

IPC: C07D471/14 ,  C07D491/147 ,  A61K31/4375

CPC classification number: C07D471/14 ,  A61K31/4375 ,  C07D217/08 ,  C07D491/14 ,  C07D491/147

Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by hepatitis B virus, and reducing the occurrence of serious conditions associated with HBV.

公开(公告)号：US20190247392A1

公开(公告)日：2019-08-15

申请号：US16210968

申请日：2018-12-05

Applicant: Novartis AG

Inventor： Jeffrey T. BAGDANOFF ,  Yu DING ,  Wooseok HAN ,  Zilin HUANG ,  Qun JIANG ,  Xianming JIN ,  Xiang KOU ,  Patrick LEE ,  Mika LINDVALL ,  Zhongcheng MIN ,  Yue PAN ,  Sabina PECCHI ,  Keith Bruce PFISTER ,  Daniel POON ,  Vivek RAUNIYAR ,  Xiaojing Michael WANG ,  Qiong ZHANG ,  Jianguang ZHOU ,  Shejin ZHU

IPC: A61K31/497 ,  A61K31/5355 ,  A61K31/4436 ,  A61K31/4433 ,  A61K31/44 ,  C07D403/06 ,  C07D401/12 ,  C07D401/06 ,  C07D213/73 ,  C07D413/14 ,  C07D241/20 ,  C07D401/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D498/04 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/4965 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/553 ,  A61K45/06

Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.

公开(公告)号：US20180028532A1

公开(公告)日：2018-02-01

申请号：US15672568

申请日：2017-08-09

Applicant: Novartis AG

Inventor： Jeffrey T. BAGDANOFF ,  Yu DING ,  Wooseok HAN ,  Zilin HUANG ,  Qun JIANG ,  Xianming JIN ,  Xiang KOU ,  Patrick LEE ,  Mika LINDVALL ,  Zhongcheng MIN ,  Yue PAN ,  Sabina PECCHI ,  Keith Bruce PFISTER ,  Daniel POON ,  Vivek RAUNIYAR ,  Xiaojing Michael WANG ,  Qiong ZHANG ,  Jianguang ZHOU ,  Shejin ZHU

IPC: A61K31/497 ,  A61K31/4433 ,  A61K31/5355 ,  A61K31/44 ,  A61K31/4436

CPC classification number: A61K31/497 ,  A61K31/44 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/4965 ,  A61K31/506 ,  A61K31/5355 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/553 ,  A61K45/06 ,  A61K2121/00 ,  C07D213/73 ,  C07D241/20 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D413/14 ,  C07D498/04

Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.

公开(公告)号：US20180030053A1

公开(公告)日：2018-02-01

申请号：US15782722

申请日：2017-10-12

Applicant: Novartis AG

Inventor： Jiping FU ,  Xianming JIN ,  Patrick LEE ,  Peichao LU ,  Joseph Michael YOUNG

IPC: C07D471/14 ,  C07D491/147 ,  A61K31/4375

CPC classification number: C07D471/14 ,  A61K31/4375 ,  C07D217/08 ,  C07D491/14 ,  C07D491/147

Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by hepatitis B virus, and reducing the occurrence of serious conditions associated with HBV.

公开(公告)号：US20170174640A1

公开(公告)日：2017-06-22

申请号：US15454187

申请日：2017-03-09

Applicant: Novartis AG

Inventor： Jiping FU ,  Xianming JIN ,  Subramanian KARUR ,  Guillaume LAPOINTE ,  Patrick LEE ,  Zachary Kevin SWEENEY

IPC: C07D261/04 ,  C07D413/04 ,  A61K31/4439 ,  A61K45/06 ,  A61K31/5377 ,  C07D417/10 ,  A61K31/427 ,  A61K31/422 ,  A61K31/42 ,  C07D413/10

CPC classification number: C07D261/04 ,  A61K31/42 ,  A61K31/421 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/5377 ,  A61K45/06 ,  C07D413/04 ,  C07D413/10 ,  C07D417/10

Abstract: This invention pertains generally to compounds of Formula I and compositions containing such compounds, as well as methods of using such compounds to treat bacterial infections. In certain aspects, the invention pertains to methods and compositions for treating infections caused by Gram-negative bacteria.

公开(公告)号：US20200270265A1

公开(公告)日：2020-08-27

申请号：US15999664

申请日：2017-02-16

Applicant: Novartis AG

Inventor： Jiping FU ,  Xianming JIN ,  Patrick LEE ,  Peichao LU ,  Joseph Michael YOUNG

IPC: C07D491/147 ,  C07D471/04 ,  C07D519/00 ,  A61P31/20

Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by hepatitis B virus, and reducing the occurrence of serious conditions associated with HBV.