公开(公告)号：US20230399382A1

公开(公告)日：2023-12-14

申请号：US18186064

申请日：2023-03-17

Applicant: Novartis AG

Inventor： Johanna ABEND ,  Zorica DRAGIC ,  Adam Lloyd FEIRE ,  Mark KNAPP ,  Steven KOVACS ,  Elisabetta TRAGGIAI ,  Lichun WANG ,  Yongqiang WANG ,  Danqing WU ,  Qilong WU ,  Fangmin XU

IPC: C07K16/08 ,  A61K39/42 ,  A61K45/06 ,  A61K9/19

CPC classification number: C07K16/084 ,  A61K39/42 ,  A61K45/06 ,  A61K9/19 ,  C07K2317/20 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/24

Abstract: The present invention relates to anti-VP1 antibodies, antibody fragments, and their uses for the prevention and treatment of polyoma virus infection and associated diseases.

公开(公告)号：US20170356006A1

公开(公告)日：2017-12-14

申请号：US15493837

申请日：2017-04-21

Applicant: NOVARTIS AG

Inventor： Zorica DRAGIC ,  Sabine GEISSE ,  Rita SCHMITZ ,  Burkhard WILMS

IPC: C12N15/85 ,  C07K16/00

CPC classification number: C12N15/85 ,  C07K16/00 ,  C12N2830/00 ,  C12N2830/30

Abstract: The present invention is based on the finding that the combination of a specific 5′UTR polynucleotide sequence (see SEQ ID NO 1) and the hCD33 secretory leader sequence in an expression cassette for expressing a polypeptide of interest results in a surprisingly better expression level of the polypeptide of interest compared to prior art expression cassettes. Based on this finding, the present invention inter alia provides novel expression cassettes, expression vectors and methods for producing a polypeptide of interest with high yield.

公开(公告)号：US20190071488A1

公开(公告)日：2019-03-07

申请号：US16183262

申请日：2018-11-07

Applicant: Novartis AG

Inventor： Johanna ABEND ,  Zorica DRAGIC ,  Adam Lloyd FEIRE ,  Mark KNAPP ,  Steven KOVACS ,  Elisabetta TRAGGIAI ,  Lichun WANG ,  Yongqiang WANG ,  Danqing WU ,  Qilong WU ,  Fangmin XU

IPC: C07K16/08 ,  A61K45/06 ,  A61K39/42

Abstract: The present invention relates to anti-VP1 antibodies, antibody fragments, and their uses for the prevention and treatment of polyoma virus infection and associated diseases.

公开(公告)号：US20250051423A1

公开(公告)日：2025-02-13

申请号：US18780282

申请日：2024-07-22

Applicant: Novartis AG

Inventor： Johanna ABEND ,  Zorica DRAGIC ,  Adam Lloyd FEIRE ,  Mark KNAPP ,  Steven KOVACS ,  Elisabetta TRAGGIAI ,  Lichun WANG ,  Yongqiang WANG ,  Danqing WU ,  Qilong WU ,  Fangmin XU

IPC: C07K16/08 ,  A61K9/19 ,  A61K39/42 ,  A61K45/06

Abstract: The present invention relates to anti-VP1 antibodies, antibody fragments, and their uses for the prevention and treatment of polyoma virus infection and associated diseases.

公开(公告)号：US20220363735A1

公开(公告)日：2022-11-17

申请号：US17502910

申请日：2021-10-15

Applicant: Novartis AG

Inventor： Johanna ABEND ,  Zorica DRAGIC ,  Adam Lloyd FEIRE ,  Mark KNAPP ,  Steven KOVACS ,  Elisabetta TRAGGIAI ,  Lichun WANG ,  Yongqiang WANG ,  Danqing WU ,  Qilong WU ,  Fangmin Xu

IPC: C07K16/08 ,  A61K39/42 ,  A61K45/06 ,  A61K9/19

Abstract: The present invention relates to anti-VP 1 antibodies, antibody fragments, and their uses for the prevention and treatment of polyoma virus infection and associated diseases.

公开(公告)号：US20180079799A1

公开(公告)日：2018-03-22

申请号：US15829115

申请日：2017-12-01

Applicant: Novartis AG

Inventor： Johanna ABEND ,  Zorica DRAGIC ,  Adam Lloyd FEIRE ,  Mark KNAPP ,  Steven KOVACS ,  Elisabetta TRAGGIAI ,  Lichun WANG ,  Yongqiang WANG ,  Danqing WU ,  Qilong WU ,  Fangmin XU

IPC: C07K16/08 ,  A61K45/06 ,  A61K39/42

CPC classification number: C07K16/084 ,  A61K9/19 ,  A61K39/42 ,  A61K45/06 ,  C07K2317/20 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to anti-VP1 antibodies, antibody fragments, and their uses for the prevention and treatment of polyoma virus infection and associated diseases.