公开(公告)号：US20190202785A1

公开(公告)日：2019-07-04

申请号：US16325880

申请日：2017-08-16

Applicant: Novartis AG

Inventor： Florian Karl KLEINBECK-RINIKER ,  Ives MAFLI ,  Benjamin MARTIN ,  Gerhard PENN ,  Gottfried SEDELMEIER ,  Joerg SEDELMEIER ,  Francesco VENTURONI

IPC: C07D213/16 ,  C07C45/49 ,  C07C249/02 ,  C07C229/06 ,  C07C201/12 ,  C07D207/267

CPC classification number: C07D213/16 ,  C07B2200/07 ,  C07C45/49 ,  C07C67/347 ,  C07C201/06 ,  C07C201/12 ,  C07C201/16 ,  C07C205/51 ,  C07C205/53 ,  C07C227/18 ,  C07C229/06 ,  C07C231/02 ,  C07C249/02 ,  C07C249/08 ,  C07C251/38 ,  C07C269/00 ,  C07C271/22 ,  C07D207/12 ,  C07D207/267 ,  C07D213/36 ,  C07C229/34 ,  C07C233/51 ,  C07C69/738

Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.