公开(公告)号：US20190308927A1

公开(公告)日：2019-10-10

申请号：US16452452

申请日：2019-06-25

Applicant: Novartis AG

Inventor： Florian Karl KLEINBECK-RINIKER ,  Benjamin MARTIN ,  Gerhard PENN ,  Francesco VENTURONI ,  Thierry SCHLAMA ,  Thomas RUCH ,  Thomas ALLMENDINGER ,  Bernhard WIETFELD ,  Paolo FILIPPONI

IPC: C07C69/738 ,  C07C67/035 ,  C07C251/40 ,  C07C59/84 ,  C07C251/66 ,  C07C51/373 ,  C07D207/36 ,  C07D265/02 ,  C07C229/34 ,  C07C313/06

Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.

公开(公告)号：US20180354889A1

公开(公告)日：2018-12-13

申请号：US15780957

申请日：2016-12-08

Applicant: Novartis AG

Inventor： Florian Karl KLEINBECK-RINIKER ,  Benjamin MARTIN ,  Gerhard PENN ,  Francesco VENTURONI ,  Thierry SCHLAMA ,  Thomas RUCH ,  Thomas ALLMENDINGER ,  Bernhard WIETFELD ,  Paolo FILIPPONI

IPC: C07C69/738 ,  C07C67/035 ,  C07C59/84 ,  C07C51/373 ,  C07C229/34 ,  C07C251/40 ,  C07C251/66 ,  C07C313/06

CPC classification number: C07C69/738 ,  C07B2200/07 ,  C07C51/373 ,  C07C59/84 ,  C07C67/035 ,  C07C229/34 ,  C07C251/40 ,  C07C251/66 ,  C07C313/06 ,  C07D207/36 ,  C07D265/02

Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.

公开(公告)号：US20190202785A1

公开(公告)日：2019-07-04

申请号：US16325880

申请日：2017-08-16

Applicant: Novartis AG

Inventor： Florian Karl KLEINBECK-RINIKER ,  Ives MAFLI ,  Benjamin MARTIN ,  Gerhard PENN ,  Gottfried SEDELMEIER ,  Joerg SEDELMEIER ,  Francesco VENTURONI

IPC: C07D213/16 ,  C07C45/49 ,  C07C249/02 ,  C07C229/06 ,  C07C201/12 ,  C07D207/267

CPC classification number: C07D213/16 ,  C07B2200/07 ,  C07C45/49 ,  C07C67/347 ,  C07C201/06 ,  C07C201/12 ,  C07C201/16 ,  C07C205/51 ,  C07C205/53 ,  C07C227/18 ,  C07C229/06 ,  C07C231/02 ,  C07C249/02 ,  C07C249/08 ,  C07C251/38 ,  C07C269/00 ,  C07C271/22 ,  C07D207/12 ,  C07D207/267 ,  C07D213/36 ,  C07C229/34 ,  C07C233/51 ,  C07C69/738

Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.

公开(公告)号：US20180022690A1

公开(公告)日：2018-01-25

申请号：US15550224

申请日：2016-02-11

Applicant: Novartis AG

Inventor： Benjamin MARTIN ,  Francesca MANDRELLI ,  Francesco VENTURONI

IPC: C07C201/10 ,  C07C205/44 ,  C07C205/04 ,  B01J31/02 ,  C07C335/16 ,  C07D207/06 ,  C07F9/535 ,  C07C205/51 ,  C07C201/12

CPC classification number: C07C201/10 ,  B01J31/0237 ,  B01J31/0241 ,  B01J31/0244 ,  B01J31/0265 ,  C07B2200/07 ,  C07C201/12 ,  C07C205/04 ,  C07C205/44 ,  C07C205/51 ,  C07C227/04 ,  C07C335/16 ,  C07C2601/14 ,  C07C2602/08 ,  C07D207/06 ,  C07F7/1804 ,  C07F9/5355 ,  C07C205/53 ,  C07C229/34

Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.