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公开(公告)号：US11236076B2
公开(公告)日：2022-02-01
申请号：US16088374
申请日：2017-03-27
申请人： Novartis AG
IPC分类号： C07D405/14 , C07C211/52 , C07C269/06 , C07D241/20 , C07D333/64 , C07D401/04 , C07D403/14 , C07D487/04
摘要： The present invention is directed to reaction mixtures comprising a water-surfactant mixture and a co-solvent. This technology reduced the amount of organic solvents needed for performing chemical reactions. Furthermore, compared to reaction mixtures lacking the co-solvent, solvation of the reactants and products of the chemical reaction is greatly enhanced, leading to a significantly improved yield, purity, reproducibility and robustness.
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公开(公告)号：US11220681B2
公开(公告)日：2022-01-11
申请号：US16478149
申请日：2018-01-11
申请人： Novartis AG
发明人： Yu Gai , Fabrice Gallou , Feng Gao , Pengfei Guo , Weiyong Kong , Michael Parmentier , Jianguang Zhou
摘要： The present invention is directed to aqueous reaction mixtures for enzymatic synthesis reactions comprising a surfactant. The surfactant in the reaction mixture increases stability and yield of the enzymatic reaction. Furthermore, method for performing an enzymatic reaction using said aqueous reaction mixtures are provided.
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公开(公告)号：US11235316B2
公开(公告)日：2022-02-01
申请号：US16316709
申请日：2017-07-10
申请人： Novartis AG
IPC分类号： C07C211/04 , B01J31/22 , B01J13/00 , B01J31/02 , B01J31/24 , C08L71/00 , B01J31/18 , C07C231/02 , C07C233/73
摘要： The present invention is directed to reaction mixtures comprising a water-surfactant mixture, wherein the catalyst comprises a compound with solubilizing groups. This technology improves the solubility of the reaction components in the water-surfactant mixture and thereby, greatly increases the productivity and selectivity of the chemical reaction.
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