公开(公告)号：US11578053B2

公开(公告)日：2023-02-14

申请号：US17546284

申请日：2021-12-09

Applicant: NOVARTIS AG

Inventor： Peng Fu ,  Yu Gai ,  Feng Gao ,  Weiyong Kong ,  Yadong Lu ,  Zhongcheng Min ,  Shaofeng Rong ,  Chutian Shu ,  Can Wang ,  Ruidong Wang ,  Jibin Zhao ,  Xianglin Zhao ,  Yi Zhao ,  Jianguang Zhou ,  Benjamin Martin

IPC: C07D401/06 ,  C07D209/04 ,  C07D211/74

Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-(((2S,4S)-(4-ethoxy-1-(((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11220681B2

公开(公告)日：2022-01-11

申请号：US16478149

申请日：2018-01-11

Applicant: Novartis AG

Inventor： Yu Gai ,  Fabrice Gallou ,  Feng Gao ,  Pengfei Guo ,  Weiyong Kong ,  Michael Parmentier ,  Jianguang Zhou

IPC: C12N9/96 ,  C12P7/22 ,  C12N9/04 ,  C12N9/02 ,  C12P17/06 ,  C12P17/12

Abstract: The present invention is directed to aqueous reaction mixtures for enzymatic synthesis reactions comprising a surfactant. The surfactant in the reaction mixture increases stability and yield of the enzymatic reaction. Furthermore, method for performing an enzymatic reaction using said aqueous reaction mixtures are provided.

公开(公告)号：US12084442B2

公开(公告)日：2024-09-10

申请号：US18057505

申请日：2022-11-21

Applicant: Novartis AG

Inventor： Atwood Kim Cheung ,  Donglei Liu ,  Stefan Peukert ,  Heng Ge ,  Yu Gai ,  Xingjuan Chang

IPC: A61K45/06 ,  C07D471/04

CPC classification number: C07D471/04 ,  A61K45/06

Abstract: The invention relates to a compound of formula (I):




or a pharmaceutically acceptable salt thereof, wherein A, R1 and R3 are as described herein, as well as compositions and methods of using such compounds.

公开(公告)号：US11208398B2

公开(公告)日：2021-12-28

申请号：US17260393

申请日：2019-07-15

Applicant: NOVARTIS AG

Inventor： Peng Fu ,  Yu Gai ,  Feng Gao ,  Weiyong Kong ,  Yadong Lu ,  Zhongcheng Min ,  Shaofeng Rong ,  Chutian Shu ,  Can Wang ,  Ruidong Wang ,  Jibin Zhao ,  Xianglin Zhao ,  Yi Zhao ,  Jianguang Zhou ,  Benjamin Martin

IPC: C07D401/06 ,  C07D209/04 ,  C07D211/74

Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-((2S,4S)-(4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.