公开(公告)号：US20220363670A1

公开(公告)日：2022-11-17

申请号：US17125335

申请日：2020-12-17

Applicant: NOVARTIS AG

Inventor： Simona Cotesta ,  Marc Gerspacher ,  Catherine Leblanc ,  Edwige Liliane Jeanne Lorthiois ,  Bo Liu ,  Rainer Machauer ,  Robert Mah ,  Christophe Mura ,  Pascal Rigollier ,  Nadine Schneider ,  Stefan Stutz ,  Andrea Vaupel ,  Nicolas Warin ,  Rainer Wilcken

IPC: C07D403/14 ,  C07D405/14 ,  C07D417/14 ,  C07D401/14 ,  C07D471/04 ,  C07D413/14 ,  C07D487/04

Abstract: The present invention provides a compound of formula (I) or a stereoisomer thereof, or an atropisomer thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of a stereoisomer thereof, or a pharmaceutically acceptable salt of an atropisomer thereof; a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.

公开(公告)号：US11702409B2

公开(公告)日：2023-07-18

申请号：US17125335

申请日：2020-12-17

Applicant: NOVARTIS AG

Inventor： Simona Cotesta ,  Marc Gerspacher ,  Catherine Leblanc ,  Edwige Liliane Jeanne Lorthiois ,  Bo Liu ,  Rainer Machauer ,  Robert Mah ,  Christophe Mura ,  Pascal Rigollier ,  Nadine Schneider ,  Stefan Stutz ,  Andrea Vaupel ,  Nicolas Warin ,  Rainer Wilcken

IPC: C07D403/14 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

CPC classification number: C07D403/14 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07B2200/13

Abstract: The present invention provides a compound of formula (I) or a stereoisomer thereof, or an atropisomer thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of a stereoisomer thereof, or a pharmaceutically acceptable salt of an atropisomer thereof;




a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.

公开(公告)号：US12226405B2

公开(公告)日：2025-02-18

申请号：US17241981

申请日：2021-04-27

Applicant: Novartis AG

Inventor： Robin Alec Fairhurst ,  Christine Fritsch ,  Marc Gerspacher ,  Jürgen Hans-Hermann Hinrichs ,  Jean-Baptiste Georges Armand Langlois ,  Catherine Leblanc ,  Tengfei Li ,  Edwige Liliane Jeanne Lorthiois ,  Christophe Mura ,  Cristina Montserrat Nieto-Oberhuber ,  Milen Todorov ,  Andrea Vaupel ,  Nicolas Warin ,  Rainer Wilcken

IPC: A61K31/437 ,  A61K31/155 ,  A61K31/436 ,  A61K31/4375 ,  A61K31/4747 ,  A61K31/519 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/635 ,  A61K31/675 ,  A61P35/00 ,  C07D471/10 ,  C07D471/20 ,  C07D491/20 ,  C07D491/22 ,  C07D495/20 ,  C07D495/22

Abstract: The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt form thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of disease.

公开(公告)号：US11492402B2

公开(公告)日：2022-11-08

申请号：US16601070

申请日：2019-10-14

Applicant: NOVARTIS AG

Inventor： Verena Brand ,  Dominik Feuerbach ,  Fabrizio Gasparini ,  Nathalie George ,  Eveline Schaadt ,  Derya Shimshek ,  Honnappa Srinivas ,  Markus Waldhuber ,  Rainer Wilcken

IPC: C07K16/28 ,  A61P25/28 ,  A61K39/395 ,  A61K39/00 ,  C12N7/00 ,  C12N15/70

Abstract: The present invention provides antibodies that bind to and stabilize human Triggering Receptor Expressed on Myeloid cells 2 (TREM2) protein and methods of using these antibodies.