公开(公告)号：US20170158747A1

公开(公告)日：2017-06-08

申请号：US15367003

申请日：2016-12-01

Applicant: Novartis AG

Inventor： Michael DIDONATO ,  Mark KNUTH ,  Shelly MEEUSEN ,  Glen SPRAGGON

IPC: C07K14/54 ,  A61K38/20 ,  A61K39/395 ,  C07K16/00 ,  A61K45/06

CPC classification number: C07K14/5428 ,  A61K38/2066 ,  A61K39/395 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/00 ,  C07K2317/51 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2318/10 ,  C07K2319/31

Abstract: The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through interleukin 10 receptor. Provided antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prophylaxis of immune related disorders. Additionally provided are polynucleotides and vectors that encode antibody cytokine engrafted proteins and host cells capable of producing antibody cytokine engrafted proteins, as well as methods of combining antibody cytokine engrafted proteins with other therapeutics in treating immune related disorder.