公开(公告)号：US20190300530A1

公开(公告)日：2019-10-03

申请号：US16383382

申请日：2019-04-12

Applicant: Novartis AG

Inventor： Jiping FU ,  Wooseok HAN ,  Subramanian KARUR ,  Peichao LU ,  Keith Bruce PFISTER ,  Joseph Michael YOUNG

IPC: C07D471/14 ,  C07D401/12 ,  C07D491/16 ,  A61P31/12 ,  A61K45/06 ,  C07D471/22 ,  A61K31/4985 ,  C07D405/12

Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by hepatitis B virus, and reducing the occurrence of serious conditions associated with HBV.

公开(公告)号：US20170088525A1

公开(公告)日：2017-03-30

申请号：US15375560

申请日：2016-12-12

Applicant: Novartis AG

Inventor： Jiping FU ,  Xianming JIN ,  Subramanian KARUR ,  Guillaume LAPOINTE ,  Ann Marie MADERA ,  Zachary Kevin SWEENEY

IPC: C07D261/08 ,  A61K31/42 ,  A61K45/06

CPC classification number: C07D261/08 ,  A61K31/42 ,  A61K31/422 ,  A61K45/06 ,  C07D413/06 ,  C07D413/12 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481 ,  A61K2300/00

Abstract: This invention pertains generally to compounds of Formula I as described herein and compositions containing such compounds, as well as methods of using such compounds to treat bacterial infections. In certain aspects, the invention provides methods and compositions comprising these compounds for treating infections caused by Gram-negative bacteria.

公开(公告)号：US20180312507A1

公开(公告)日：2018-11-01

申请号：US15965172

申请日：2018-04-27

Applicant: Novartis AG

Inventor： Jiping FU ,  Wooseok HAN ,  Subramanian KARUR ,  Peichao LU ,  Keith Bruce PFISTER ,  Joseph Michael YOUNG

IPC: C07D471/14 ,  C07D405/12 ,  C07D401/12 ,  C07D491/16 ,  A61P31/12

CPC classification number: C07D471/14 ,  A61K31/4985 ,  A61K45/06 ,  A61P31/12 ,  C07D401/12 ,  C07D405/12 ,  C07D471/22 ,  C07D491/16

Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by hepatitis B virus, and reducing the occurrence of serious conditions associated with HBV.

公开(公告)号：US20170174640A1

公开(公告)日：2017-06-22

申请号：US15454187

申请日：2017-03-09

Applicant: Novartis AG

Inventor： Jiping FU ,  Xianming JIN ,  Subramanian KARUR ,  Guillaume LAPOINTE ,  Patrick LEE ,  Zachary Kevin SWEENEY

IPC: C07D261/04 ,  C07D413/04 ,  A61K31/4439 ,  A61K45/06 ,  A61K31/5377 ,  C07D417/10 ,  A61K31/427 ,  A61K31/422 ,  A61K31/42 ,  C07D413/10

CPC classification number: C07D261/04 ,  A61K31/42 ,  A61K31/421 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/5377 ,  A61K45/06 ,  C07D413/04 ,  C07D413/10 ,  C07D417/10

Abstract: This invention pertains generally to compounds of Formula I and compositions containing such compounds, as well as methods of using such compounds to treat bacterial infections. In certain aspects, the invention pertains to methods and compositions for treating infections caused by Gram-negative bacteria.

公开(公告)号：US20200270252A1

公开(公告)日：2020-08-27

申请号：US16808985

申请日：2020-03-04

Applicant: Novartis AG

Inventor： Jiping FU ,  Wooseok HAN ,  Subramanian KARUR ,  Peichao LU ,  Keith Bruce PFISTER ,  Joseph Michael YOUNG

IPC: C07D471/14 ,  C07D405/12 ,  A61P31/12 ,  C07D491/16 ,  C07D401/12 ,  A61K45/06 ,  A61K31/4985 ,  C07D471/22

Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by hepatitis B virus, and reducing the occurrence of serious conditions associated with HBV.

公开(公告)号：US20180030004A1

公开(公告)日：2018-02-01

申请号：US15728351

申请日：2017-10-09

Applicant: Novartis AG

Inventor： Jiping FU ,  Xianming JIN ,  Subramanian KARUR ,  Guillaume LAPOINTE ,  Ann Marie MADERA ,  Zachary Kevin SWEENEY

IPC: C07D261/08 ,  A61K45/06 ,  A61K31/42 ,  A61K31/422 ,  C07D413/12 ,  C07D413/06

CPC classification number: C07D261/08 ,  A61K31/42 ,  A61K31/422 ,  A61K45/06 ,  C07D413/06 ,  C07D413/12 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481 ,  A61K2300/00

Abstract: This invention pertains generally to compounds of Formula I as described herein and compositions containing such compounds, as well as methods of using such compounds to treat bacterial infections. In certain aspects, the invention provides methods and compositions comprising these compounds for treating infections caused by Gram-negative bacteria.