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公开(公告)号：US20230212186A1
公开(公告)日：2023-07-06
申请号：US18068195
申请日：2022-12-19
发明人： Arthur T. SANDS , Neil F. BENCE , Christoph W. ZAPF , Frederick COHEN , Chenbo WANG , Thomas CUMMINS , Hiroko TANAKA , Hunter SHUNATONA , Mario CARDOZO , Dahlia WEISS , Jennifa GOSLING
IPC分类号： C07D403/12 , C07D403/14 , C07D413/14 , C07D401/14 , C07D405/14 , C07D491/08 , C07D471/04
CPC分类号： C07D403/12 , C07D403/14 , C07D413/14 , C07D401/14 , C07D405/14 , C07D491/08 , C07D471/04
摘要： Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising a Cbl-b inhibitor and a cancer vaccine, as well as methods for treating cancer using a Cbl-b inhibitor and a cancer vaccine; and pharmaceutical compositions comprising a Cbl-b inhibitor and an oncolytic virus, as well as methods for treating cancer using a Cbl-b inhibitor and an oncolytic virus.
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公开(公告)号：US20210053986A1
公开(公告)日：2021-02-25
申请号：US16875917
申请日：2020-05-15
发明人： Arthur T. SANDS , Neil F. BENCE , Christoph W. ZAPF , Frederick COHEN , Chenbo WANG , Thomas CUMMINS , Hiroko TANAKA , Hunter SHUNATONA , Mario CARDOZO , Dahlia WEISS , Jennifa GOSLING
IPC分类号： C07D498/08 , C07D403/12 , C07D403/14 , C07D413/14 , C07D471/04
摘要： Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising a Cbl-b inhibitor and a cancer vaccine, as well as methods for treating cancer using a Cbl-b inhibitor and a cancer vaccine; and pharmaceutical compositions comprising a Cbl-b inhibitor and an oncolytic virus, as well as methods for treating cancer using a Cbl-b inhibitor and an oncolytic virus.
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公开(公告)号：US20220378839A1
公开(公告)日：2022-12-01
申请号：US17864307
申请日：2022-07-13
发明人： Arthur T. SANDS , Neil F. BENCE , Christoph W. ZAPF , Frederick COHEN , Chenbo WANG , Thomas CUMMINS , Hiroko TANAKA , Hunter SHUNATONA , Mario CARDOZO , Dahlia WEISS , Jennifa GOSLING
IPC分类号： A61K35/17 , A61P35/00 , A61K33/243 , A61K31/438 , A61K31/454 , A61K31/4545 , A61K35/761 , A61K35/763 , A61K35/768 , A61K38/19 , A61K39/00 , A61K39/39 , A61K39/395 , A61K45/06 , A61N5/10 , C07D401/14 , C07D405/14 , C07D471/04 , C07D491/107 , C07F5/02 , C12N5/0783
摘要： Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising a Cbl-b inhibitor and a cancer vaccine, as well as methods for treating cancer using a Cbl-b inhibitor and a cancer vaccine; and pharmaceutical compositions comprising a Cbl-b inhibitor and an oncolytic virus, as well as methods for treating cancer using a Cbl-b inhibitor and an oncolytic virus.
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公开(公告)号：US20220324835A1
公开(公告)日：2022-10-13
申请号：US16964979
申请日：2019-01-25
发明人： Paul A. BARSANTI , Neil F. BENCE , Jennifa GOSLING , Anjanabha SAHA , Asad M TAHERBHOY , Christoph W. ZAPF , Kathleen BOYLE , Mario CARDOZO , Jeffrey MIHALIC , Morgan LAWRENZ , Mark GALLOP , Jilliane BRUFFEY , Thomas CUMMINS , Daniel ROBBINS , Hiroko TANAKA , Chenbo WANG , Frederick COHEN , Wylie PALMER , Arthur T. SANDS , Hunter SHUNATONA
IPC分类号： C07D401/14 , A61K35/17 , A61K39/00 , C07D249/12 , A61K31/4196 , C07D401/12 , A61K31/455 , C07D403/12 , A61K31/506 , A61K31/4725 , A61K31/4709 , A61K31/497 , A61K31/4375 , C07D471/04 , A61K31/427 , C07D417/12 , C07D405/14 , A61K31/428 , C07D413/14 , A61K31/423 , A61K31/4545 , A61K31/496 , C07D413/12 , C07D491/107 , C07D413/10 , A61K31/4245 , A61K31/4155 , A61K31/4178 , C07D403/10 , C07D487/04 , A61K31/433 , C07D491/052 , C07D451/02 , A61K31/55 , C07D471/08 , A61K31/5377 , A61K31/541 , C07D403/14 , C07D417/14 , A61K31/438 , A61K31/499 , A61K31/4985 , C07D491/08 , A61K31/436 , A61K31/4748 , A61K31/437 , C07D498/04 , A61K31/5386 , C07D498/10 , A61P35/00 , A61K39/39 , C07D453/02 , C12N5/0783 , C12N5/0781
摘要： Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo.
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公开(公告)号：US20210053961A1
公开(公告)日：2021-02-25
申请号：US16913949
申请日：2020-06-26
发明人： Arthur T. SANDS , Neil F. BENCE , Christoph W. ZAPF , Frederick COHEN , Chenbo WANG , Thomas CUMMINS , Hiroko TANAKA , Hunter SHUNATONA , Mario CARDOZO , Dahlia WEISS , Jennifa GOSLING
IPC分类号： C07D413/14 , C07D401/14 , C07D471/04 , C07D405/14 , C07D403/10 , C07D403/12
摘要： Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising a Cbl-b inhibitor and a cancer vaccine, as well as methods for treating cancer using a Cbl-b inhibitor and a cancer vaccine; and pharmaceutical compositions comprising a Cbl-b inhibitor and an oncolytic virus, as well as methods for treating cancer using a Cbl-b inhibitor and an oncolytic virus.
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