公开(公告)号：US20190038337A1

公开(公告)日：2019-02-07

申请号：US16057115

申请日：2018-08-07

Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

Inventor： Karl H. SCHOENBACH ,  Richard HELLER ,  James CAMP ,  Stephen P. BEEBE ,  Shu XIAO ,  Amy DONATE

IPC: A61B18/12 ,  A61N5/06 ,  A61N1/32 ,  A61N1/40 ,  A61N5/00 ,  A61N5/02 ,  A61B18/00 ,  A61B18/24 ,  A61B18/20 ,  A61B18/18 ,  A61N5/067

CPC classification number: A61B18/1206 ,  A61B18/12 ,  A61B18/1815 ,  A61B18/20 ,  A61B18/24 ,  A61B2018/00613 ,  A61B2018/00761 ,  A61B2018/00767 ,  A61B2018/00791 ,  A61B2018/00994 ,  A61N1/327 ,  A61N1/403 ,  A61N5/00 ,  A61N5/025 ,  A61N5/0625 ,  A61N2005/0651 ,  A61N2005/0666 ,  A61N2005/067

Abstract: Systems and methods for treatment of a biological tissues including target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.