公开(公告)号：US20200147371A1

公开(公告)日：2020-05-14

申请号：US16669419

申请日：2019-10-30

Applicant: Old Dominion University Research Foundation

Inventor： Andrei G. PAKHOMOV ,  Shu XIAO ,  Olga N. PAKHOMOVA ,  Maura CASCIOLA

IPC: A61N1/36 ,  A61N1/04 ,  A61N1/08

Abstract: Methods and apparatuses (systems, devices, etc.) for treating biological tissue to evoke one or more desirable biological and/or physiological effects using pulsed electric fields in the sub-microsecond range at very low electric field strength (e.g., less than 1 kV/cm) but at high (e.g., megahertz) frequencies.

公开(公告)号：US20200259261A1

公开(公告)日：2020-08-13

申请号：US16273112

申请日：2019-02-11

Applicant: Old Dominion University Research Foundation

Inventor： Shu XIAO ,  Xianbing ZOU

IPC: H01Q9/04 ,  H01P3/16

Abstract: Resistively loaded dielectric biconical antenna apparatuses, including systems and devices, that may be used to transmit very short electrical pulses (e.g., nanosecond, sub-nanosecond, picosecond, etc.) into tissue non-invasively at energy levels sufficient to invoke biological changes in the tissue. These resistively loaded dielectric biconical antenna apparatuses may include a resistor ring reducing internal reflection and reducing energy loss, as well as delivering longer pulses (e.g. microsecond to millisecond) to tissue.

公开(公告)号：US20190038337A1

公开(公告)日：2019-02-07

申请号：US16057115

申请日：2018-08-07

Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

Inventor： Karl H. SCHOENBACH ,  Richard HELLER ,  James CAMP ,  Stephen P. BEEBE ,  Shu XIAO ,  Amy DONATE

IPC: A61B18/12 ,  A61N5/06 ,  A61N1/32 ,  A61N1/40 ,  A61N5/00 ,  A61N5/02 ,  A61B18/00 ,  A61B18/24 ,  A61B18/20 ,  A61B18/18 ,  A61N5/067

CPC classification number: A61B18/1206 ,  A61B18/12 ,  A61B18/1815 ,  A61B18/20 ,  A61B18/24 ,  A61B2018/00613 ,  A61B2018/00761 ,  A61B2018/00767 ,  A61B2018/00791 ,  A61B2018/00994 ,  A61N1/327 ,  A61N1/403 ,  A61N5/00 ,  A61N5/025 ,  A61N5/0625 ,  A61N2005/0651 ,  A61N2005/0666 ,  A61N2005/067

Abstract: Systems and methods for treatment of a biological tissues including target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.

公开(公告)号：US20210268274A1

公开(公告)日：2021-09-02

申请号：US17306314

申请日：2021-05-03

Applicant: Old Dominion University Research Foundation

Inventor： Andrei G. PAKHOMOV ,  Olga N. PAKHOMOVA ,  Shu XIAO

IPC: A61N1/32 ,  C12N13/00

Abstract: Provided herein are methods of generating a biologically effective unipolar nanosecond electric pulse by superposing two biologically ineffective bipolar nanosecond electric pulses and related aspects, such as electroporation and/or therapeutic applications of these methods to non-invasively target electrostimulation (ES) selectively to deep tissues and organs.

公开(公告)号：US20190054294A1

公开(公告)日：2019-02-21

申请号：US16104089

申请日：2018-08-16

Applicant: Old Dominion University Research Foundation

Inventor： Andrei G. PAKHOMOV ,  Olga N. PAKHOMOVA ,  Shu XIAO

IPC: A61N1/32 ,  A61N1/04 ,  A61N1/36 ,  C12N13/00

Abstract: Provided herein are methods of generating a biologically effective unipolar nanosecond electric pulse by superposing two biologically ineffective bipolar nanosecond electric pulses and related aspects, such as electroporation and/or therapeutic applications of these methods to non-invasively target electrostimulation (ES) selectively to deep tissues and organs.

公开(公告)号：US20180296837A1

公开(公告)日：2018-10-18

申请号：US16014822

申请日：2018-06-21

Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

Inventor： Shu XIAO ,  Andrei PAKHOMOV ,  Karl H. SCHOENBACH

IPC: A61N1/36 ,  A61N5/02 ,  A61N2/00 ,  A61N1/40

CPC classification number: A61N1/36014 ,  A61N1/40 ,  A61N2/006 ,  A61N5/02

Abstract: A system for treatment of biological tissues is provided. The system can deliver electric pulses to a targeted region within a biological tissue. The system includes an antenna assembly and a lens. The antenna assembly is configured to generate and direct electromagnetic radiation. The lens is configured to be positioned between a surface of the biological tissue and the antenna assembly. The lens can have a plurality of lossy portions. The lens can be configured to be adjustable to create a patient-specific desired electric field distribution by selective positioning of the plurality of lossy portions within the lens.