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公开(公告)号:US20150148291A1
公开(公告)日:2015-05-28
申请号:US14555258
申请日:2014-11-26
申请人: OPKO BIOLOGICS LTD.
发明人: UDI EYAL FIMA , GILI HART
IPC分类号: C07K14/59 , C07K14/505
CPC分类号: C07K14/59 , C07K14/505 , C07K14/555 , C07K14/61 , C07K2319/00 , C07K2319/31 , C07K2319/35
摘要: A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.
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公开(公告)号:US20200255816A1
公开(公告)日:2020-08-13
申请号:US16865086
申请日:2020-05-01
申请人: OPKO Biologics Ltd.
发明人: UDI EYAL FIMA , GILI HART
IPC分类号: C12N9/64 , C07K14/745 , C07K14/59 , C07K14/505 , C12N9/96
摘要: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
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