公开(公告)号：US20200255816A1

公开(公告)日：2020-08-13

申请号：US16865086

申请日：2020-05-01

申请人： OPKO Biologics Ltd.

发明人： UDI EYAL FIMA ,  GILI HART

IPC分类号： C12N9/64 ,  C07K14/745 ,  C07K14/59 ,  C07K14/505 ,  C12N9/96

摘要： Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.

公开(公告)号：US20150203558A1

公开(公告)日：2015-07-23

申请号：US14566370

申请日：2014-12-10

申请人： OPKO BIOLOGICS LTD.

发明人： FUAD FARES ,  UDI EYAL FIMA

IPC分类号： C07K14/555 ,  C07K14/59

CPC分类号： C07K14/555 ,  A61K38/19 ,  A61K47/64 ,  C07K14/505 ,  C07K14/59 ,  C07K14/61 ,  C07K2319/00 ,  C07K2319/31 ,  C07K2319/35 ,  C07K2319/91

摘要： A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.

公开(公告)号：US20150158926A1

公开(公告)日：2015-06-11

申请号：US14555308

申请日：2014-11-26

申请人： OPKO BIOLOGICS, LTD.

发明人： FUAD FARES ,  UDI EYAL FIMA

IPC分类号： C07K14/61 ,  A61K38/24 ,  A61K38/27 ,  C07K14/59

CPC分类号： A61K38/27 ,  A61K38/24 ,  A61K47/02 ,  A61K47/12 ,  C07K14/505 ,  C07K14/555 ,  C07K14/59 ,  C07K14/61 ,  C07K2319/00 ,  C07K2319/31 ,  G01N33/74 ,  G01N2333/65 ,  G01N2800/52

摘要： CTP-modified human growth hormone polypeptides and pharmaceutical formulations and pharmaceutical compositions comprising the same and methods of producing, and using the same are disclosed.

摘要翻译： 公开了CTP-修饰的人生长激素多肽和药物制剂和包含其的药物组合物以及制备和使用它们的方法。

公开(公告)号：US20150148291A1

公开(公告)日：2015-05-28

申请号：US14555258

申请日：2014-11-26

申请人： OPKO BIOLOGICS LTD.

发明人： UDI EYAL FIMA ,  GILI HART

IPC分类号： C07K14/59 ,  C07K14/505

CPC分类号： C07K14/59 ,  C07K14/505 ,  C07K14/555 ,  C07K14/61 ,  C07K2319/00 ,  C07K2319/31 ,  C07K2319/35

摘要： A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.

公开(公告)号：US20150126445A1

公开(公告)日：2015-05-07

申请号：US14566681

申请日：2014-12-10

申请人： OPKO BIOLOGICS LTD.

发明人： FUAD FARES ,  UDI EYAL FIMA

IPC分类号： C07K14/505 ,  C07K14/59

CPC分类号： C07K14/505 ,  C07K14/555 ,  C07K14/59 ,  C07K14/61 ,  C07K2319/00 ,  C07K2319/31

摘要： A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.

公开(公告)号：US20150126444A1

公开(公告)日：2015-05-07

申请号：US14566663

申请日：2014-12-10

申请人： OPKO BIOLOGICS, LTD.

发明人： FUAD FARES ,  UDI EYAL FIMA

IPC分类号： C07K14/505 ,  A61M5/178 ,  C07K14/59

CPC分类号： C07K14/505 ,  A61M5/178 ,  C07K14/555 ,  C07K14/59 ,  C07K14/61 ,  C07K2319/00 ,  C07K2319/31

摘要： CTP-modified human growth hormone polypeptides and pharmaceutical formulations and pharmaceutical compositions comprising the same and methods of producing, and using the same are disclosed.

公开(公告)号：US20150119320A1

公开(公告)日：2015-04-30

申请号：US14592641

申请日：2015-01-08

申请人： OPKO BIOLOGICS LTD.

发明人： UDI EYAL FIMA ,  OREN HERSHKOVITZ

IPC分类号： A61K47/48 ,  A61K38/22

CPC分类号： A61K47/60 ,  A61K38/22 ,  A61K38/26

摘要： A composition which includes oxyntomodulin and polyethylene glycol polymer (PEG polymer) linked via a reversible linker such as 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS) is disclosed. Pharmaceutical compositions comprising the reverse pegylated oxyntomodulin and methods of using same are also disclosed.

公开(公告)号：US20150093358A1

公开(公告)日：2015-04-02

申请号：US14555246

申请日：2014-11-26

申请人： OPKO BIOLOGICS LTD.

发明人： FUAD FARES ,  UDI EYAL FIMA

IPC分类号： C07K14/59 ,  C07K14/555 ,  C07K14/605 ,  C07K14/505

CPC分类号： C07K14/59 ,  A61K38/1816 ,  C07K14/505 ,  C07K14/555 ,  C07K14/605 ,  C07K14/61 ,  C07K2319/00 ,  C07K2319/31

摘要： A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also discarded.

摘要翻译： 公开了包含至少两个附着于非人感兴趣肽的绒毛膜促性腺激素的羧基末端肽（CTP）的多肽和多核苷酸。 还丢弃了包含本发明的非人多肽和多核苷酸的药物组合物以及使用人和非人多肽和多核苷酸两者的方法。