公开(公告)号：US20150119320A1

公开(公告)日：2015-04-30

申请号：US14592641

申请日：2015-01-08

申请人： OPKO BIOLOGICS LTD.

发明人： UDI EYAL FIMA ,  OREN HERSHKOVITZ

IPC分类号： A61K47/48 ,  A61K38/22

CPC分类号： A61K47/60 ,  A61K38/22 ,  A61K38/26

摘要： A composition which includes oxyntomodulin and polyethylene glycol polymer (PEG polymer) linked via a reversible linker such as 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS) is disclosed. Pharmaceutical compositions comprising the reverse pegylated oxyntomodulin and methods of using same are also disclosed.

公开(公告)号：US20210008172A1

公开(公告)日：2021-01-14

申请号：US16924810

申请日：2020-07-09

申请人： OPKO Biologics Ltd.

发明人： OREN HERSHKOVITZ ,  Lital Israeli-Yagev ,  Ahuva Bar-Ilan ,  Laura Moschcovich ,  Moran Golan

IPC分类号： A61K38/30 ,  C07K1/107 ,  C12N15/64 ,  C12N15/69 ,  A61K38/27 ,  A61K38/17

摘要： Compositions which include polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus or amino terminus of an insulin-like growth factor 1 (IGF-1) or IGF-1 variant. Polynucleotides encoding the same are disclosed. Pharmaceutical compositions and pharmaceutical formulations comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.