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公开(公告)号：US20190276804A1
公开(公告)日：2019-09-12
申请号：US16348944
申请日：2017-11-09
Applicant: OSAKA UNIVERSITY , KYOTO UNIVERSITY
Inventor： Kiyotoshi SEKIGUCHI , Fumi EBISU , Hidetoshi SAKURAI , Mingming ZHAO , Megumu SAITO
Abstract: Provided is a method for inducing pluripotent stem cells to differentiate into somatic cells in a culture medium containing a heparin binding growth factor, the method comprising bringing cells into contact with a conjugate of a laminin E8 fragment and a growth factor binding domain-containing fragment of a heparan sulfate proteoglycan. According to the present invention, pluripotent stem cells can be induced to differentiate into any desired somatic cells in a highly efficient manner.
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