公开(公告)号：US20230203131A1

公开(公告)日：2023-06-29

申请号：US17923323

申请日：2021-05-07

Applicant: OSAKA UNIVERSITY ,  MATRIXOME, INC.

Inventor： Kiyotoshi SEKIGUCHI ,  Mamoru TAKIZAWA ,  Yukimasa TANIGUCHI

IPC: C07K14/75 ,  C07K14/78 ,  C12N5/00

CPC classification number: C07K14/75 ,  C07K14/78 ,  C12N5/0068 ,  C12N5/0062 ,  C07K2319/00 ,  C12N2513/00

Abstract: The present invention provides a gel formed of fibrin and a molecule generated by thrombin treatment of a chimeric protein that comprises a fibrinogen fragment capable of binding to fibrinogen upon thrombin treatment and a laminin fragment having integrin-binding activity, and optionally further comprises a protein having growth factor-binding activity. The gel of the present invention is suitable as a gel substrate that has properties of the basement membrane and can be used in medical applications.