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公开(公告)号：US20210046122A1
公开(公告)日：2021-02-18
申请号：US16961354
申请日：2019-01-11
Applicant: OSAKA UNIVERSITY , ROHTO PHARMACEUTICAL CO., LTD.
Inventor： Kohji NISHIDA , Ryuhei HAYASHI , Shun SHIBATA , Toru OKUBO , Yoichi HONMA
Abstract: The present invention addresses the problem of providing a novel therapeutic agent that is effective against diseases involving stratified squamous epithelial cells such as dry eye syndrome. The present invention is an agent for promoting normal differentiation/maturation of stratified squamous epithelial cells, which comprises a secretion of mesenchymal stem cells. It is preferable that the secretions not include animal serum, that the mesenchymal stem cells be adipose-derived mesenchymal stem cells, umbilical cord-derived mesenchymal stem cells, or bone marrow-derived mesenchymal stem cells, and that the stratified squamous epithelial cells be at least one selected from the group consisting of corneal epithelial cells, conjunctival epithelial cells, epidermal keratinocytes, oral epithelial cells, epiglottic epithelial cells, esophageal epithelial cells, vaginal epithelial cells, vocal fold epithelial cells, nasal epithelial cells, and nasal vestibular epithelial cells.
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公开(公告)号：US20180148685A1
公开(公告)日：2018-05-31
申请号：US15543021
申请日：2016-01-12
Applicant: Osaka University
Inventor： Kohji Nishida , Yuzuru SASAMOTO , Ryuhei HAYASHI
Abstract: The present invention relates to a method for inducing a keratin 12-positive corneal epithelioid cell from a surface ectoderm-derived cell. More specifically, the present invention relates to a method for inducing a keratin 12-positive corneal epithelioid cell, comprising introducing PAX6, KLF4, and OCT4 into a surface ectoderm-derived cell, such as an oral mucosal epithelial cell, and a corneal epithelioid cell induced by the method.
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3.发明申请公开(公告)号：US20180010093A1
公开(公告)日：2018-01-11
申请号：US15542200
申请日：2016-01-13
Applicant: Osaka University
Inventor： Kohji Nishida , Ryuhei HAYASHI , Yuki ISHIKAWA
CPC classification number: C12N5/0621 , C12N5/0607 , C12N5/10 , C12N2500/90 , C12N2501/117 , C12N2501/727 , C12N2506/45
Abstract: The present invention relates to a method for inducing the differentiation of corneal epithelial cells from pluripotent stem cells. More specifically, the present invention relates to a method for autonomously differentiating pluripotent stem cells, such as human iPS cells, into ectodermal cell lineage in a serum-free medium without using feeder cells and inducing the differentiation of the resultant ocular surface ectodermal lineage cells into corneal epithelial cells.
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4.发明申请公开(公告)号：US20210371818A1
公开(公告)日：2021-12-02
申请号：US17348174
申请日：2021-06-15
Applicant: Osaka University
Inventor： Kohji NISHIDA , Ryuhei HAYASHI , Yuki ISHIKAWA
Abstract: The present invention relates to a method for inducing the differentiation of corneal epithelial cells from pluripotent stem cells. More specifically, the present invention relates to a method for autonomously differentiating pluripotent stem cells, such as human iPS cells, into ectodermal cell lineage in a serum-free medium without using feeder cells and inducing the differentiation of the resultant ocular surface ectodermal lineage cells into corneal epithelial cells.
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