公开(公告)号：US20210046122A1

公开(公告)日：2021-02-18

申请号：US16961354

申请日：2019-01-11

Applicant: OSAKA UNIVERSITY ,  ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Kohji NISHIDA ,  Ryuhei HAYASHI ,  Shun SHIBATA ,  Toru OKUBO ,  Yoichi HONMA

IPC: A61K35/28 ,  A61P27/02

Abstract: The present invention addresses the problem of providing a novel therapeutic agent that is effective against diseases involving stratified squamous epithelial cells such as dry eye syndrome. The present invention is an agent for promoting normal differentiation/maturation of stratified squamous epithelial cells, which comprises a secretion of mesenchymal stem cells. It is preferable that the secretions not include animal serum, that the mesenchymal stem cells be adipose-derived mesenchymal stem cells, umbilical cord-derived mesenchymal stem cells, or bone marrow-derived mesenchymal stem cells, and that the stratified squamous epithelial cells be at least one selected from the group consisting of corneal epithelial cells, conjunctival epithelial cells, epidermal keratinocytes, oral epithelial cells, epiglottic epithelial cells, esophageal epithelial cells, vaginal epithelial cells, vocal fold epithelial cells, nasal epithelial cells, and nasal vestibular epithelial cells.

公开(公告)号：US20190015452A1

公开(公告)日：2019-01-17

申请号：US15749766

申请日：2016-08-03

Applicant: OSAKA UNIVERSITY ,  ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Kohji NISHIDA ,  Ryuuhei HAYASHI ,  Yoichi HONMA ,  Toru OKUBO ,  Shun SHIBATA

IPC: A61K35/28 ,  A61P27/02 ,  C12N5/0775 ,  C12N5/00

Abstract: The present invention relates to mesenchymal stem cell-derived microparticles having activity that promotes the growth of corneal epithelial stem cells and/or corneal epithelial cells, activity that maintains corneal epithelial stem cells in an undifferentiated state or promotes the formation of colonies thereby, and function that protects corneal epithelium.