公开(公告)号：US20240252541A1

公开(公告)日：2024-08-01

申请号：US18357976

申请日：2023-07-24

申请人： Ossium Health, Inc. ,  The Trustees of Columbia University in the City of New York

发明人： Erik J. WOODS ,  Brian H. JOHNSTONE ,  Dongsheng GU ,  Aubrey Marie SHERRY ,  Kelsey Gwen MUSALL ,  Kazuhiko YAMADA ,  Megan SYKES

IPC分类号： A61K35/28 ,  A61K31/44 ,  A61K45/06 ,  A61P37/06 ,  C07K16/26 ,  C07K16/28

CPC分类号： A61K35/28 ,  A61K31/44 ,  A61K45/06 ,  A61P37/06 ,  C07K16/26 ,  C07K16/2806 ,  C07K16/2875

摘要： Described herein are methods of cell therapies. Also described herein are methods of establishing a mixed chimerism, and/or preventing a rejection of a donor organ in a subject wherein said subject has received an organ transplant, the method comprising administering to said subject a population of hematopoietic cells, wherein said organ transplant comprises a heart transplant.

公开(公告)号：US20240207322A1

公开(公告)日：2024-06-27

申请号：US18456422

申请日：2023-08-25

申请人： OSSIUM HEALTH, INC.

发明人： Erik J. WOODS ,  Brian H. JOHNSTONE ,  Dongsheng GU ,  Aubrey Marie SHERRY ,  Kelsey Gwen MUSALL ,  Megan SYKES ,  Tomoaki KATO ,  Jianing FU

IPC分类号： A61K35/28 ,  A61K31/436 ,  A61K35/17 ,  A61K35/38 ,  A61K38/17 ,  A61P37/06 ,  C12N5/0783 ,  C12N5/0789

CPC分类号： A61K35/28 ,  A61K31/436 ,  A61K35/17 ,  A61K35/38 ,  A61K38/1774 ,  A61P37/06 ,  C12N5/0636 ,  C12N5/0647

摘要： Described herein are methods of cell therapies. Also described herein are methods of generating donor derived T cells in an organ transplant recipient, by administering bone marrow stem cells to the organ transplant recipient about 1 to about 30 days after the organ transplant recipient receives one or more organ transplants.