公开(公告)号：US20240216436A1

公开(公告)日：2024-07-04

申请号：US18486907

申请日：2023-10-13

申请人： Ossium Health, Inc. ,  Emory University ,  Children's Healthcare of Atlanta

发明人： Edwin M. HORWITZ ,  Erik J. WOODS, SR. ,  Brian H. JOHNSTONE ,  Hannah Marie MILLER

IPC分类号： A61K35/28 ,  A61P37/06

CPC分类号： A61K35/28 ,  A61P37/06

摘要： The present disclosure provides composition and methods comprising interferon γ-primed human mesenchymal stromal cells (γMSCs) for preventing or reducing the likelihood of Graft Versus Host Disease (GVHD) or a symptom thereof in a human subject that has been administered a hematopoietic stem cell transplant (HCT).

公开(公告)号：US20240240151A1

公开(公告)日：2024-07-18

申请号：US18448864

申请日：2023-08-11

申请人： OSSIUM HEALTH, INC.

发明人： Erik J. WOODS ,  Brian H. JOHNSTONE ,  Dongsheng GU ,  Hannah Marie MILLER

IPC分类号： C12N5/0775 ,  C12N9/52

CPC分类号： C12N5/0663 ,  C12N9/52 ,  C12N2509/00

摘要： Compositions and methods for the extraction mesenchymal cells from deceased donor bone, and therapeutic applications thereof, along with combination therapeutic applications comprising mesenchymal cells from deceased donors and bone marrow derived from deceased donors are presented.

公开(公告)号：US20210317415A1

公开(公告)日：2021-10-14

申请号：US17227217

申请日：2021-04-09

申请人： Ossium Health, Inc.

发明人： Erik J. WOODS ,  Brian H. JOHNSTONE

IPC分类号： C12N5/077 ,  C12N5/0775 ,  C12N5/0789

摘要： Provided herein are methods and systems for recovering bone marrow. The methods comprising perfusing a bone with a perfusion media and recovering the liberated bone marrow cells.

公开(公告)号：US20240260567A1

公开(公告)日：2024-08-08

申请号：US18545891

申请日：2023-12-19

申请人： Ossium Health, Inc.

发明人： Erik J. WOODS ,  Brian H. JOHNSTONE

IPC分类号： A01N1/02 ,  C12N5/0775 ,  C12N5/0789

CPC分类号： A01N1/0284 ,  A01N1/0221 ,  A01N1/0289 ,  C12N5/0647 ,  C12N5/0663 ,  C12N2509/00

摘要： The present disclosure relates to, at least, a vacuum-assisted method for infiltrating cadaver bone with a cryoprotectant and a method for rapidly warming the cryopreserved cadaver bone for bone marrow processing.

公开(公告)号：US20210214688A1

公开(公告)日：2021-07-15

申请号：US17199376

申请日：2021-03-11

申请人： Ossium Health, Inc.

发明人： Erik J. WOODS ,  Brian H. JOHNSTONE ,  Dongsheng GU ,  Aubrey Marie SHERRY ,  Kelsey Gwen MUSALL ,  John R. WOODS ,  James HARDIN ,  Alan HOOKS

IPC分类号： C12N5/0775 ,  A61B17/16 ,  A01N1/02

摘要： Methods are provided for extracting bone marrow cells from bone obtained from deceased donors, for preparing the bone marrow for cryopreservation and for obtaining desired cells from cryopreserved and fresh bone marrow.

公开(公告)号：US20210037810A1

公开(公告)日：2021-02-11

申请号：US17079309

申请日：2020-10-23

申请人： Ossium Health, Inc.

发明人： Erik J. Woods ,  Brian H. JOHNSTONE ,  Joseph INGALLS

IPC分类号： A01N1/02 ,  C12N5/077

摘要： A bone cutting assembly includes a manually actuated upper cutting element that carries a plurality of cutting blades configured to cut through frozen bone segments. A lower cutting element supports a bone segment to be cut and can include cutting blades aligned with the cutting blades of the upper cutting assembly. A pivoting linkage or a rack and pinion arrangement can be provided between the upper cutting element and a manually operated handle to provide sufficient mechanical advantage or leverage to allow an operator to manually cut through the bone.

公开(公告)号：US20240271098A1

公开(公告)日：2024-08-15

申请号：US18412312

申请日：2024-01-12

申请人： OSSIUM HEALTH, INC.

发明人： Erik J. WOODS ,  Brian H. JOHNSTONE ,  Dongsheng GU ,  Aubrey Marie SHERRY ,  Kelsey Gwen MUSALL ,  John R. WOODS ,  James HARDIN ,  Alan HOOKS

IPC分类号： C12N5/0775 ,  A01N1/02 ,  A61B17/00 ,  A61B17/16

CPC分类号： C12N5/0663 ,  A01N1/0221 ,  A61B17/1611 ,  A61B2017/00831

摘要： Methods are provided for extracting bone marrow cells from bone obtained from deceased donors, for preparing the bone marrow for cryopreservation and for obtaining desired cells from cryopreserved and fresh bone marrow.

公开(公告)号：US20240252541A1

公开(公告)日：2024-08-01

申请号：US18357976

申请日：2023-07-24

申请人： Ossium Health, Inc. ,  The Trustees of Columbia University in the City of New York

发明人： Erik J. WOODS ,  Brian H. JOHNSTONE ,  Dongsheng GU ,  Aubrey Marie SHERRY ,  Kelsey Gwen MUSALL ,  Kazuhiko YAMADA ,  Megan SYKES

IPC分类号： A61K35/28 ,  A61K31/44 ,  A61K45/06 ,  A61P37/06 ,  C07K16/26 ,  C07K16/28

CPC分类号： A61K35/28 ,  A61K31/44 ,  A61K45/06 ,  A61P37/06 ,  C07K16/26 ,  C07K16/2806 ,  C07K16/2875

摘要： Described herein are methods of cell therapies. Also described herein are methods of establishing a mixed chimerism, and/or preventing a rejection of a donor organ in a subject wherein said subject has received an organ transplant, the method comprising administering to said subject a population of hematopoietic cells, wherein said organ transplant comprises a heart transplant.

公开(公告)号：US20240207322A1

公开(公告)日：2024-06-27

申请号：US18456422

申请日：2023-08-25

申请人： OSSIUM HEALTH, INC.

发明人： Erik J. WOODS ,  Brian H. JOHNSTONE ,  Dongsheng GU ,  Aubrey Marie SHERRY ,  Kelsey Gwen MUSALL ,  Megan SYKES ,  Tomoaki KATO ,  Jianing FU

IPC分类号： A61K35/28 ,  A61K31/436 ,  A61K35/17 ,  A61K35/38 ,  A61K38/17 ,  A61P37/06 ,  C12N5/0783 ,  C12N5/0789

CPC分类号： A61K35/28 ,  A61K31/436 ,  A61K35/17 ,  A61K35/38 ,  A61K38/1774 ,  A61P37/06 ,  C12N5/0636 ,  C12N5/0647

摘要： Described herein are methods of cell therapies. Also described herein are methods of generating donor derived T cells in an organ transplant recipient, by administering bone marrow stem cells to the organ transplant recipient about 1 to about 30 days after the organ transplant recipient receives one or more organ transplants.

公开(公告)号：US20240164371A1

公开(公告)日：2024-05-23

申请号：US18352942

申请日：2023-07-14

申请人： OSSIUM HEALTH, INC.

发明人： Erik J. WOODS ,  Brian H. JOHNSTONE ,  Dongsheng GU ,  Aubrey Marie SHERRY ,  Kelsey Gwen MUSALL

IPC分类号： A01N1/02

CPC分类号： A01N1/0284 ,  A01N1/0221 ,  A01N1/0252

摘要： Methods, systems, and compositions are provided for extracting bone marrow cells from bone obtained from deceased donors, for preparing the bone marrow for cryopreservation, and for obtaining desired cells from cryopreserved and fresh bone marrow