公开(公告)号：US11249076B2

公开(公告)日：2022-02-15

申请号：US14464971

申请日：2014-08-21

Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

Inventor： Kusunoki Higashino ,  Yasuhiro Sando ,  Kenichi Miyata

IPC: G01N33/543 ,  B01F5/06 ,  B01F11/00 ,  B01F15/00 ,  B01F5/10 ,  B01F11/02 ,  B01F13/00 ,  B01L3/00

Abstract: A test device having a micro flow channel including a reaction part where a reactant that is reactive to a tested chemical dispersed in a tested fluid is fixed, and at least one actuator for actuating the tested fluid to move in at least one of two opposite sides of the micro flow channel so as to homogenize a density distribution of the tested chemical in the tested fluid. The tested fluid is sent in the micro flow channel a plurality of times.

公开(公告)号：US09597283B2

公开(公告)日：2017-03-21

申请号：US14758108

申请日：2013-12-27

Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

Inventor： Daiki Kaneko ,  Takakuni Matsuda ,  Kenichi Miyata ,  Kai Suzuki ,  Hiroyuki Fujiki ,  Shizuo Kinoshita ,  Koji Ohmoto ,  Miki Aihara

IPC: A61K9/16 ,  A61K9/00 ,  A61K47/38 ,  A61K47/32 ,  A61K47/10 ,  A61K9/10 ,  A61K9/14 ,  A61K31/55

CPC classification number: A61K9/0019 ,  A61K9/0024 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/1652 ,  A61K9/1688 ,  A61K9/1694 ,  A61K31/55 ,  A61K47/10 ,  A61K47/32 ,  A61K47/38

Abstract: This invention provides an injectable formulation to be administered intramuscularly or subcutaneously that is used for the prevention or treatment of polycystic kidney disease, and that can maintain a therapeutically effective blood concentration of tolvaptan for a long period of time; and a process for producing the same. More specifically, this invention relates to an injectable depot formulation comprising (1) a particle containing optically active tolvaptan as an active ingredient and (2) a pharmaceutically acceptable carrier for injection, and a process for producing the same.