公开(公告)号：US20210069248A1

公开(公告)日：2021-03-11

申请号：US17017670

申请日：2020-09-10

申请人： Obsidian Therapeutics, Inc.

发明人： Kutlu Goksu ELPEK ,  Meghan C. LANGLEY ,  Tucker Read EZELL ,  Dexue SUN ,  Jennifer Leah GORI ,  Geetha Hanna MYLVAGANAM ,  Michelle OLS ,  Michelle FLEURY ,  Celeste RICHARDSON ,  James A. STORER ,  Vipin SURI ,  Shyamsundar SUBRAMANIAN ,  Colleen FOLEY ,  Molly Reed PERKINS ,  Jeremy Hatem TCHAICHA ,  Scott Francis HELLER

IPC分类号： A61K35/17 ,  C12N15/86 ,  C07K14/54 ,  C12N9/88 ,  A61K31/433

摘要： The present disclosure provides drug responsive domains derived from human carbonic anhydrase 2 that can modulate protein stability for human interleukin 15 (IL15) payloads, as well as compositions and methods of use thereof.

公开(公告)号：US20220332780A1

公开(公告)日：2022-10-20

申请号：US17753594

申请日：2020-09-10

申请人： Obsidian Therapeutics, Inc.

发明人： Kutlu Goksu ELPEK ,  Dhruv Kam SETHI ,  Meghan C. LANGLEY ,  Tucker Read EZELL ,  Dexue SUN ,  Jennifer Leah GORI ,  Geetha Hanna MYLVAGANAM ,  Michelle OLS ,  Michelle FLEURY ,  Celeste RICHARDSON ,  James A. STORER ,  Vipin SURI ,  Shyamsundar SUBRAMANIAN ,  Colleen FOLEY ,  Molly Reed PERKINS ,  Jeremy Hatem TCHAICHA ,  Scott Francis HELLER

IPC分类号： C07K14/54 ,  C07K14/725 ,  A61K31/427 ,  A61K35/17 ,  A61P35/00 ,  C12N15/62 ,  C12N5/0783 ,  C12N15/86 ,  C12N9/88

摘要： The present disclosure provides drug responsive domains derived from human carbonic anhydrase 2 that can modulate protein stability for human interleukin 15 (EL15) payloads, as well as compositions and methods of use thereof.