公开(公告)号：US20230026259A1

公开(公告)日：2023-01-26

申请号：US17436892

申请日：2020-03-06

申请人： Obsidian Therapeutics, Inc.

发明人： Vipin SURI ,  Celeste RICHARDSON ,  Brian DOLINSKI ,  Abhishek KULKARNI ,  Mara Christine Inniss ,  Dexue SUN ,  Elizabeth Jane WEISMAN ,  Grace Y. Olinger ,  Scott Francis HELLER ,  Jennifer Leah GORI ,  Michelle Lynn OLS ,  Kutlu Goksu ELPEK ,  Tucker Read EZELL ,  Michael SCHEBESTA ,  Michelle Lois FLEURY ,  Dhruv Kam SETHI

IPC分类号： C12N9/88 ,  A61K39/00 ,  C07K14/705

摘要： The present disclosure provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities. In particular, the present application is directed to fusion proteins comprising a fragment of human human carbonic anhydrase 2 and a chimeric antigen receptor (CAR). The activity of the destabilizing domain can be regulated by externally administered agents.

公开(公告)号：US20220267398A1

公开(公告)日：2022-08-25

申请号：US17596277

申请日：2020-06-12

申请人： Obsidian Therapeutics, Inc.

发明人： Michelle Lynn OLS ,  Vipin SURI ,  Dexue SUN ,  Dhruv Kam SETHI ,  Michael SCHEBESTA ,  Michelle Lois FLEURY ,  Kutlu Goksu ELPEK

IPC分类号： C07K14/54 ,  C07K14/725 ,  C07K14/705 ,  C12N9/88

摘要： The present disclosure provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.

公开(公告)号：US20220056092A1

公开(公告)日：2022-02-24

申请号：US17413512

申请日：2019-12-11

申请人： Obsidian Therapeutics, Inc.

发明人： Michelle Lynn OLS ,  Vipin SURI ,  Dexue SUN ,  Dan Jun LI ,  Dhruv Kam SETHI ,  Abhishek KULKARNI ,  Benjamin J. PRIMACK ,  James STORER

IPC分类号： C07K14/54 ,  C07K14/725 ,  C07K16/28 ,  A61K35/17 ,  A61P35/00

摘要： The present disclosure provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.

公开(公告)号：US20220332780A1

公开(公告)日：2022-10-20

申请号：US17753594

申请日：2020-09-10

申请人： Obsidian Therapeutics, Inc.

发明人： Kutlu Goksu ELPEK ,  Dhruv Kam SETHI ,  Meghan C. LANGLEY ,  Tucker Read EZELL ,  Dexue SUN ,  Jennifer Leah GORI ,  Geetha Hanna MYLVAGANAM ,  Michelle OLS ,  Michelle FLEURY ,  Celeste RICHARDSON ,  James A. STORER ,  Vipin SURI ,  Shyamsundar SUBRAMANIAN ,  Colleen FOLEY ,  Molly Reed PERKINS ,  Jeremy Hatem TCHAICHA ,  Scott Francis HELLER

IPC分类号： C07K14/54 ,  C07K14/725 ,  A61K31/427 ,  A61K35/17 ,  A61P35/00 ,  C12N15/62 ,  C12N5/0783 ,  C12N15/86 ,  C12N9/88

摘要： The present disclosure provides drug responsive domains derived from human carbonic anhydrase 2 that can modulate protein stability for human interleukin 15 (EL15) payloads, as well as compositions and methods of use thereof.

公开(公告)号：US20220175781A1

公开(公告)日：2022-06-09

申请号：US17436997

申请日：2020-03-06

申请人： Obsidian Therapeutics, Inc.

发明人： Michael SCHEBESTA ,  Michelle Lois FLEURY ,  Kutlu Goksu ELPEK ,  Elizabeth Jane WEISMAN ,  Vipin SURI ,  Dexue SUN ,  Dan Jun LI ,  Steven Mark SHAMAH ,  Michael Joseph BRISKIN ,  Celeste RICHARDSON ,  Tariq A. KASSUM ,  Michelle Lynn OLS ,  Brian DOLINSKI ,  Mara Christine INNISS ,  Emily BRIDEAU ,  Jennifer Leah GORI ,  Dhruv Kam SETHI

IPC分类号： A61K31/519 ,  C12N9/06 ,  A61K31/55

摘要： The present disclosure provides regulatable biocircuit systems, effector modules and compositions for cancer immunotherapy. Methods for inducing anti-cancer immune responses in a subject are also provided.