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公开(公告)号：US20160264619A1
公开(公告)日：2016-09-15
申请号：US15164736
申请日：2016-05-25
申请人： Octapharma AG
发明人： Petra Schulz , Rainer Pape , Werner Gehringer
摘要： The present invention relates to a method or process for the manufacture of a virus and prion save native fibrinogen concentrate of high purity and low amounts of fibrinopeptide A and fibronectin.
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公开(公告)号：US20150045539A1
公开(公告)日：2015-02-12
申请号：US14382712
申请日：2013-03-12
申请人： OCTAPHARMA AG
发明人： Petra Schulz , Werner Ghringer , Friedrich Schön , Caroline Leitinger , Jürgen Römisch , Rainer Pape
摘要： A process for purifying fibrinogen from a fibrinogen containing source by precipitation of fibrinogen by a precipitating agent from a fibrinogen containing solution in the presence of one or more chelating agent(s) and removal of the supernatant from the fibrinogen paste, characterised in that fibrinogen is extracted from the paste forming a liquid fraction containing fibrinogen, and an undissolved residue, which is separated from the liquid.
摘要翻译： 一种通过在一种或多种螯合剂存在下由含纤维蛋白原溶液沉淀纤维蛋白原的纤维蛋白原来净化纤维蛋白原的方法，并从纤维蛋白原糊中除去上清液，其特征在于纤维蛋白原为 从形成含有纤维蛋白原的液体部分的糊剂中提取，和从液体中分离的未溶解残余物。
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公开(公告)号：US20190016755A1
公开(公告)日：2019-01-17
申请号：US16136003
申请日：2018-09-19
申请人： OCTAPHARMA AG
发明人： Petra Schulz , Werner Gehringer , Friedrich Schön , Caroline Leitinger , Jürgen Römisch , Rainer Pape
摘要： A process for purifying fibrinogen from a fibrinogen containing source by precipitation of fibrinogen by a precipitating agent from a fibrinogen containing solution in the presence of one or more chelating agent(s) and removal of the supernatant from the fibrinogen paste, characterised in that fibrinogen is extracted from the paste forming a liquid fraction containing fibrinogen, and an undissolved residue, which is separated from the liquid.
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公开(公告)号：US09938318B2
公开(公告)日：2018-04-10
申请号：US15164736
申请日：2016-05-25
申请人： OCTAPHARMA AG
发明人： Petra Schulz , Rainer Pape , Werner Gehringer
摘要： The present invention relates to a method or process for the manufacture of a virus and prion save native fibrinogen concentrate of high purity and low amounts of fibrinopeptide A and fibronectin.
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公开(公告)号：US10112972B2
公开(公告)日：2018-10-30
申请号：US14382712
申请日：2013-03-12
申请人： OCTAPHARMA AG
发明人： Petra Schulz , Werner Gehringer , Friedrich Schön , Caroline Leitinger , Jürgen Römisch , Rainer Pape
摘要： A process for purifying fibrinogen from a fibrinogen containing source by precipitation of fibrinogen by a precipitating agent from a fibrinogen containing solution in the presence of one or more chelating agent(s) and removal of the supernatant from the fibrinogen paste, characterized in that fibrinogen is extracted from the paste forming a liquid fraction containing fibrinogen, and an undissolved residue, which is separated from the liquid.
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公开(公告)号：US20150031621A1
公开(公告)日：2015-01-29
申请号：US14327110
申请日：2014-07-09
申请人： OCTAPHARMA AG
IPC分类号： C07K14/47
CPC分类号： C07K14/472 , A61K38/1709 , C07K1/36 , C07K14/435 , C07K14/47
摘要： A method for purification of complement Factor H from a complement Factor H containing source such as blood or blood plasma, in particular a caprylate precipitate of a Factor H containing source, which is e.g. obtained by addition of caprylate ions to fractions of blood or plasma, comprising the steps of: a) providing a Factor H containing source, in particular reconstitution of caprylate precipitate to provide a complement Factor H containing solution; b) performing a cation exchange chromatography in particular as first chromatographic step; c) performing an anion exchange chromatography; d) performing a hydroxyl apatite chromatography; e) followed by ultra/diafiltration to obtain a complement Factor H concentrate.
摘要翻译： 用于从补体因子H纯化补体因子H的方法，所述补体因子H含有血液或血浆中的源，特别是含H因子的来源的辛酸盐沉淀物。 通过向血液或血浆的级分中加入辛酸盐离子获得，包括以下步骤：a）提供含有因子H的来源，特别是辛酸沉淀重构以提供补体因子H的溶液; b）特别是进行阳离子交换层析作为第一色谱步骤; c）进行阴离子交换层析; d）进行羟基磷灰石层析; e），然后进行超/渗滤以获得补体因子H浓缩物。
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