公开(公告)号：US20170368359A1

公开(公告)日：2017-12-28

申请号：US15699905

申请日：2017-09-08

Applicant: Oculeve, Inc.

Inventor： James Donald LOUDIN ,  Manfred FRANKE ,  Daniel N. HAMILTON ,  Anand DORAISWAMY ,  Douglas Michael ACKERMANN

IPC: A61N1/378 ,  A61N1/36

CPC classification number: A61N1/3787 ,  A61N1/36046 ,  A61N1/3606 ,  A61N1/36121 ,  A61N1/3756 ,  B29D11/00038 ,  B29D11/00826

Abstract: Described here are devices, systems, and methods for increasing tear production by stimulating the cornea, conjunctiva, and/or subconjunctiva. In some variations, the devices may be in the form of a contact lens. The contact lens may comprise a lens body and a stimulator chip, where the stimulator chip is embedded in the lens body. An external power source wirelessly transmits energy to the stimulator chip, where the stimulator chip may convert the energy to an electric waveform to stimulate the cornea, conjunctiva, and/or subconjunctiva. Stimulation may activate the lacrimal reflex to increase tear production. The devices and systems for increasing tear production may be used in methods of treating dry eye, reducing the symptoms of tired eye, increasing comfort for contact lens wearers, and extending the number of years a contact lens user can wear contacts. Also described are methods of manufacturing a contact lens.

公开(公告)号：US20170368333A1

公开(公告)日：2017-12-28

申请号：US15700935

申请日：2017-09-11

Applicant: Oculeve, Inc.

Inventor： James Donald LOUDIN ,  Amitava GUPTA ,  John WARDLE ,  Christopher William STIVERS ,  Anand DORAISWAMY ,  Marie Dvorak CHRIST ,  F. Richard CHRIST

IPC: A61N1/05 ,  C08F230/08 ,  H01B1/12 ,  C08F220/54 ,  A61N1/04 ,  A61N1/36

CPC classification number: A61N1/0546 ,  A61N1/0456 ,  A61N1/0496 ,  A61N1/36014 ,  C08F220/54 ,  C08F230/08 ,  H01B1/125 ,  Y10T29/49826 ,  Y10T29/49885 ,  C08F226/10 ,  C08F220/20 ,  C08F2222/1013 ,  C08F2230/085

Abstract: Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.

公开(公告)号：US20160114172A1

公开(公告)日：2016-04-28

申请号：US14920847

申请日：2015-10-22

Applicant: Oculeve, Inc.

Inventor： James Donald LOUDIN ,  Manfred FRANKE ,  Daniel N. HAMILTON ,  Anand DORAISWAMY ,  Douglas Michael ACKERMANN

IPC: A61N1/378 ,  A61N1/36

CPC classification number: A61N1/3787 ,  A61N1/36046 ,  A61N1/36121 ,  B29D11/00038 ,  B29D11/00826

Abstract: Described here are devices, systems, and methods for increasing tear production by stimulating the cornea, conjunctiva, and/or subconjunctiva. In some variations, the devices may be in the form of a contact lens. The contact lens may comprise a lens body and a stimulator chip, where the stimulator chip is embedded in the lens body. An external power source wirelessly transmits energy to the stimulator chip, where the stimulator chip may convert the energy to an electric waveform to stimulate the cornea, conjunctiva, and/or subconjunctiva. Stimulation may activate the lacrimal reflex to increase tear production. The devices and systems for increasing tear production may be used in methods of treating dry eye, reducing the symptoms of tired eye, increasing comfort for contact lens wearers, and extending the number of years a contact lens user can wear contacts. Also described are methods of manufacturing a contact lens.

Abstract translation: 这里描述了通过刺激角膜，结膜和/或结膜下增加泪液产生的装置，系统和方法。 在一些变型中，装置可以是隐形眼镜的形式。 隐形眼镜可以包括透镜体和刺激器芯片，其中刺激器芯片嵌入在透镜体中。 外部电源将能量无线地传输到刺激器芯片，其中刺激器芯片可以将能量转换成电波形以刺激角膜，结膜和/或结膜下。 刺激可以激活泪液反射以增加泪液产生。 用于增加泪液生产的装置和系统可以用于治疗干眼症，减少疲劳眼睛的症状，增加隐形眼镜佩戴者的舒适度以及延长隐形眼镜用户可佩戴接触的年数的方法。 还描述了制造隐形眼镜的方法。

公开(公告)号：US20180280688A1

公开(公告)日：2018-10-04

申请号：US15904036

申请日：2018-02-23

Applicant: Oculeve, Inc.

Inventor： James Donald LOUDIN ,  Amitava GUPTA ,  John WARDLE ,  Christopher William STIVERS ,  Anand DORAISWAMY ,  Marie Dvorak CHRIST ,  F. Richard CHRIST

IPC: A61N1/05 ,  H01B1/12 ,  C08F220/54 ,  C08F220/20 ,  C08F226/10 ,  C08F230/08 ,  A61N1/04 ,  A61N1/36 ,  C08F222/10

Abstract: Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.

公开(公告)号：US20150238754A1

公开(公告)日：2015-08-27

申请号：US14630471

申请日：2015-02-24

Applicant: Oculeve, Inc.

Inventor： James Donald LOUDIN ,  Amitava GUPTA ,  John WARDLE ,  Christopher William STIVERS ,  Anand DORAISWAMY ,  Marie Dvorak CHRIST ,  F. Richard CHRIST

IPC: A61N1/05 ,  H01B13/00 ,  A61N1/36 ,  H01B1/12

CPC classification number: A61N1/0546 ,  A61N1/0456 ,  A61N1/0496 ,  A61N1/36014 ,  C08F220/54 ,  C08F230/08 ,  H01B1/125 ,  Y10T29/49826 ,  Y10T29/49885 ,  C08F226/10 ,  C08F220/20 ,  C08F2222/1013 ,  C08F2230/085

Abstract: Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.

Abstract translation: 本文描述的是用于促进鼻或鼻窦组织的电刺激的聚合物制剂。 聚合物制剂可以是通过UV交联方法制备的水凝胶。 可以将水凝胶作为鼻刺激装置的组分包含，以刺激泪腺以改善泪液的产生并治疗干眼症。 此外，本文描述了用于制造鼻刺激器的装置和方法，包括水凝胶的成形。