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公开(公告)号:US20200017489A1
公开(公告)日:2020-01-16
申请号:US16521925
申请日:2019-07-25
申请人: Ohio University
IPC分类号: C07D417/14 , A61K31/4166 , A61K31/427 , A61K31/428 , A61K31/155 , A61K31/4439 , A61K45/06 , C07D233/84 , C07D277/16 , C07D277/36 , C07D277/84 , C07D405/04 , C07D413/04 , C07D417/04 , C07D417/06
摘要: Compounds having General Formula (I) or General Formula (II): in which R1 is chosen from C1 to C10 aliphatic or heteroaliphatic groups, optionally substituted with one or more aryl groups, substituted aryl groups, heteroaryl groups, substituted heteroaryl groups, or combination thereof, R2 is chosen from aromatic moieties, substituted aromatic moieties, heteroaromatic moieties, substituted heteroaromatic moieties, and coumarin; R3 is chosen from —H, C1 to C10 aliphatic or heteroaliphatic groups, phenyl, or substituted phenyl, wherein the aliphatic or heteroaliphatic groups are optionally substituted with one or more phenyl groups, aryl groups, heteroaryl groups, substituted heteroaryl groups, or combination thereof, and wherein the aliphatic or heteroaliphatic groups are optionally bonded to R2 to form a ring; X is S or O; and Y is S or NH, may be used in pharmaceutical compositions that modify of biological signaling processes or as reagents for biological assays.
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公开(公告)号:US10407420B2
公开(公告)日:2019-09-10
申请号:US15975321
申请日:2018-05-09
申请人: Ohio University
IPC分类号: C07D417/14 , C07D233/84 , C07D277/16 , C07D277/36 , C07D277/84 , C07D405/04 , C07D413/04 , C07D417/06 , A61K31/4166 , A61K31/427 , A61K31/428 , A61K31/155 , A61K31/4439 , A61K45/06 , C07D417/04
摘要: Compounds having General Formula (I) or General Formula (II): in which R1 is chosen from C1 to C10 aliphatic or heteroaliphatic groups, optionally substituted with one or more aryl groups, substituted aryl groups, heteroaryl groups, substituted heteroaryl groups, or combination thereof; R2 is chosen from aromatic moieties, substituted aromatic moieties, heteroaromatic moieties, substituted heteroaromatic moieties, and coumarin; R3 is chosen from —H, C1 to C10 aliphatic or heteroaliphatic groups, phenyl, or substituted phenyl, wherein the aliphatic or heteroaliphatic groups are optionally substituted with one or more phenyl groups, aryl groups, heteroaryl groups, substituted heteroaryl groups, or combination thereof, and wherein the aliphatic or heteroaliphatic groups are optionally bonded to R2 to form a ring; X is S or O; and Y is S or NH, may be used in pharmaceutical compositions that modify of biological signaling processes or as reagents for biological assays.
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公开(公告)号:US20170210737A1
公开(公告)日:2017-07-27
申请号:US15326821
申请日:2015-05-06
申请人: Ohio University
IPC分类号: C07D417/14 , C07D413/04 , C07D405/04 , C07D417/04 , C07D417/06 , C07D277/36 , C07D277/84 , C07D233/84 , C07D277/16
CPC分类号: C07D417/14 , A61K31/155 , A61K31/4166 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K45/06 , C07D233/84 , C07D277/16 , C07D277/36 , C07D277/84 , C07D405/04 , C07D413/04 , C07D417/04 , C07D417/06 , Y02A50/411
摘要: Compounds having General Formula (I) or General Formula (II): in which R1 is chosen from C1 to C10 aliphatic or heteroaliphatic groups, optionally substituted with one or more aryl groups, substituted aryl groups, heteroaryl groups, substituted heteroaryl groups, or combination thereof; R2 is chosen from aromatic moieties, substituted aromatic moieties, heteroaromatic moieties substituted heteroaromatic moieties, and coumarin; R3 is chosen from —H, C1 to C10 aliphatic or heteroaliphatic groups, phenyl, or substituted phenyl, wherein the aliphatic or heteroaliphatic groups are optionally substituted with one or more phenyl groups, aryl groups, heteroaryl groups, substituted heteroaryl groups, or combination thereof, and wherein the aliphatic or heteroaliphatic groups are optionally bonded to R2 to form a ring; X is S or O; and Y is S or NH, may be used in pharmaceutical compositions that modify of biological signaling processes or as reagents for biological assays.
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公开(公告)号:US20170202818A1
公开(公告)日:2017-07-20
申请号:US15326782
申请日:2015-05-06
申请人: Ohio University
发明人: Douglas Goetz , Kelly D. McCall , Stephen C. Bergmeier , Frank L. Schwartz , Pooja Bhatt , Sudhir Deosarkar
IPC分类号: A61K31/4439 , A61K31/427
CPC分类号: C07D417/14 , A61K31/155 , A61K31/4166 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K45/06 , C07D233/84 , C07D277/16 , C07D277/36 , C07D277/84 , C07D405/04 , C07D413/04 , C07D417/04 , C07D417/06 , Y02A50/411
摘要: Methods for modulating GSK-3 activity and methods for treating a GSK-3-mediated disorder in a subject in need thereof. The methods include contacting a cell expressing GSK-3 with or administering to the subject in need a therapeutically effective amount of one or more compounds of General Formula (I) or General Formula (II): or pharmaceutically-acceptable salts or solvates thereof.
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公开(公告)号:US20180362521A1
公开(公告)日:2018-12-20
申请号:US15975321
申请日:2018-05-09
申请人: Ohio University
IPC分类号: C07D417/14 , C07D277/36 , C07D417/04 , A61K31/155 , A61K31/427 , C07D413/04 , C07D277/84 , C07D233/84 , C07D417/06 , A61K45/06 , C07D277/16 , A61K31/4166 , C07D405/04 , A61K31/4439 , A61K31/428
CPC分类号: C07D417/14 , A61K31/155 , A61K31/4166 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K45/06 , C07D233/84 , C07D277/16 , C07D277/36 , C07D277/84 , C07D405/04 , C07D413/04 , C07D417/04 , C07D417/06 , Y02A50/411
摘要: Compounds having General Formula (I) or General Formula (II): in which R1 is chosen from C1 to C10 aliphatic or heteroaliphatic groups, optionally substituted with one or more aryl groups, substituted aryl groups, heteroaryl groups, substituted heteroaryl groups, or combination thereof; R2 is chosen from aromatic moieties, substituted aromatic moieties, heteroaromatic moieties, substituted heteroaromatic moieties, and coumarin; R3 is chosen from —H, C1 to C10 aliphatic or heteroaliphatic groups, phenyl, or substituted phenyl, wherein the aliphatic or heteroaliphatic groups are optionally substituted with one or more phenyl groups, aryl groups, heteroaryl groups, substituted heteroaryl groups, or combination thereof, and wherein the aliphatic or heteroaliphatic groups are optionally bonded to R2 to form a ring; X is S or O; and Y is S or NH, may be used in pharmaceutical compositions that modify of biological signaling processes or as reagents for biological assays.
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公开(公告)号:US10023567B2
公开(公告)日:2018-07-17
申请号:US15326821
申请日:2015-05-06
申请人: Ohio University
IPC分类号: C07D417/14 , C07D233/84 , C07D413/04 , C07D405/04 , C07D277/16 , C07D417/06 , C07D277/36 , C07D277/84 , C07D417/04
摘要: Compounds having General Formula (I) or General Formula (II): in which R1 is chosen from C1 to C10 aliphatic or heteroaliphatic groups, optionally substituted with one or more aryl groups, substituted aryl groups, heteroaryl groups, substituted heteroaryl groups, or combination thereof; R2 is chosen from aromatic moieties, substituted aromatic moieties, heteroaromatic moieties substituted heteroaromatic moieties, and coumarin; R3 is chosen from —H, C1 to C10 aliphatic or heteroaliphatic groups, phenyl, or substituted phenyl, wherein the aliphatic or heteroaliphatic groups are optionally substituted with one or more phenyl groups, aryl groups, heteroaryl groups, substituted heteroaryl groups, or combination thereof, and wherein the aliphatic or heteroaliphatic groups are optionally bonded to R2 to form a ring; X is S or O; and Y is S or NH, may be used in pharmaceutical compositions that modify of biological signaling processes or as reagents for biological assays.
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