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公开(公告)号：US09993368B2
公开(公告)日：2018-06-12
申请号：US12914940
申请日：2010-10-28
CPC分类号： A61F9/00781 , A61F9/0017 , A61F9/007 , A61F2009/00891 , A61F2250/0067 , A61K9/0051 , A61M27/002 , A61M2210/0612 , Y10S623/905
摘要： Surgical methods and related medical devices for treating ocular disorders are disclosed. Some methods relate to delivering an implant within an eye, and involve providing an elongate guide device, such as, a flexible guide member or a guide wire. A distal end of the guide device can be advanced into an anterior chamber of an eye, or through at least a portion of a site of resistance along a physiologic outflow pathway of the eye, or from an anterior chamber of the eye to a location proximate a physiologic outflow pathway of the eye. The implant is advanced along the guide device toward the guide device distal end, and is positioned to conduct aqueous humor between the anterior chamber and the physiologic outflow pathway.
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公开(公告)号：US20090138081A1
公开(公告)日：2009-05-28
申请号：US12366565
申请日：2009-02-05
申请人： Olav B. Bergheim , Morteza Gharib
发明人： Olav B. Bergheim , Morteza Gharib
CPC分类号： A61F9/00781 , A61F9/0017 , A61F9/007 , A61F2009/00891 , A61F2250/0067 , A61K9/0051 , A61M27/002 , A61M2210/0612 , Y10S623/905
摘要： Implants and methods for treating ocular disorders are disclosed. One implant has an inlet portion configured to extend through a portion of a tissue of an eye and an outlet portion configured to extend into and along a physiologic outflow pathway of the eye. The implant provides a flow path between an anterior chamber of the eye and the physiologic outflow pathway. One implant includes a body having adjacent regions of differing cross-sectional dimensions configured to anchor the implant and/or stabilize at least a portion of the flow path through the implant. One method involves inserting a fiber optic in an eye, locating a distal end of the fiber optic at a physiologic outflow pathway through which aqueous humor drains from an anterior chamber of the eye, and delivering a material comprising a therapeutic agent along the fiber optic and into the physiologic outflow pathway.
摘要翻译： 公开了用于治疗眼部疾病的植入物和方法。 一个植入物具有被配置为延伸穿过眼睛的组织的一部分的入口部分和被配置为延伸到眼睛的生理流出道中并沿着眼睛的生理流出路径的出口部分。 植入物提供眼睛前房和生理流出路径之间的流动路径。 一个植入物包括具有不同横截面尺寸的相邻区域的主体，其被构造成锚定植入物和/或稳定通过植入物的流动路径的至少一部分。 一种方法是将光纤插入到眼睛中，将光纤的远端定位在生理学流出路径，通过该生理流出路径，房水从眼睛的前房排出，以及沿着光纤传送包含治疗剂的材料， 进入生理流出途径。
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公开(公告)号：US09987472B2
公开(公告)日：2018-06-05
申请号：US12979249
申请日：2010-12-27
申请人： Hosheng Tu , Gregory T. Smedley , David Steven Haffner , Barbara A. Niksch , Richard A. Hill , Olav B. Bergheim
发明人： Hosheng Tu , Gregory T. Smedley , David Steven Haffner , Barbara A. Niksch , Richard A. Hill , Olav B. Bergheim
CPC分类号： A61M27/00 , A61F9/00781
摘要： Systems and methods for treating ocular disorders are disclosed. One system has a delivery instrument, with a non-linear axis, configured to be inserted into an anterior chamber of an eye and moved to a location proximate a physiologic outflow pathway of the eye. The delivery instrument carries an implant that has a distal end sized for insertion into tissue such that aqueous humor drains from the anterior chamber to the physiologic outflow pathway. One method involves inserting a non-linear portion of a delivery device into the anterior chamber to position an implant within the eye. Another method involves using a delivery device with a curved distal portion to implant an implant at a location communicating with the physiologic outflow pathway. The delivery can be through a corneal incision and the implant can comprise a drug.
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公开(公告)号：US06780164B2
公开(公告)日：2004-08-24
申请号：US10395627
申请日：2003-03-21
IPC分类号： A61M500
CPC分类号： A61F9/00781 , A61F9/0017 , A61F9/007 , A61F2009/00891 , A61F2250/0067 , A61K9/0051 , A61M27/002 , A61M2210/0612 , Y10S623/905
摘要： Surgical methods and related medical devices for treating glaucoma are disclosed. The method comprises trabecular bypass surgery, which involve bypassing diseased trabecular meshwork with the use of a seton implant. The seton implant is used to prevent a healing process known as filling in, which has a tendency to close surgically created openings in the trabecular meshwork. The surgical method and novel implant are addressed to the trabecular meshwork, which is a major site of resistance to outflow in glaucoma. In addition to bypassing the diseased trabecular meshwork at the level of the trabecular meshwork, existing outflow pathways are also used or restored. The seton implant is positioned through the trabecular meshwork so that an inlet end of the seton implant is exposed to the anterior chamber of the eye and an outlet end is positioned into fluid collection channels at about an exterior surface of the trabecular meshwork or up to the level of aqueous veins.
摘要翻译： 公开了用于治疗青光眼的手术方法和相关的医疗装置。 该方法包括小梁旁路手术，其涉及利用植入物绕过患病的小梁网。 镶嵌植入物用于防止称为填充的愈合过程，其具有在小梁网中关闭手术产生的开口的趋势。 手术方法和新型植入物是针对小梁网，其是青光眼流出阻力的主要部位。 除了在小梁网的水平绕过患病的小梁网，还使用或恢复现有的流出路径。 镶嵌植入物定位成穿过小梁网，使得植入植入物的入口端暴露于眼睛的前房，并且出口端被定位在小梁网的大约外表面处的流体收集通道中，或者直到 水静脉水平。
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公开(公告)号：US06638239B1
公开(公告)日：2003-10-28
申请号：US09549350
申请日：2000-04-14
IPC分类号： A61M100
CPC分类号： A61F9/00781 , A61F9/0017 , A61F9/007 , A61F2009/00891 , A61F2250/0067 , A61K9/0051 , A61M27/002 , A61M2210/0612 , Y10S623/905
摘要： Surgical methods and related medical devices for treating glaucoma are disclosed. The method comprises trabecular bypass surgery, which involve bypassing diseased trabecular meshwork with the use of a seton implant. The seton implant is used to prevent a healing process known as filling in, which has a tendency to close surgically created openings in the trabecular meshwork. The surgical method and novel implant are addressed to the trabecular meshwork, which is a major site of resistance to outflow in glaucoma. In addition to bypassing the diseased trabecular meshwork at the level of the trabecular meshwork, existing outflow pathways are also used or restored. The seton implant is positioned through the trabecular meshwork so that an inlet end of the seton implant is exposed to the anterior chamber of the eye and an outlet end is positioned into fluid collection channels at about an exterior surface of the trabecular meshwork or up to the level of aqueous veins.
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公开(公告)号：US08333742B2
公开(公告)日：2012-12-18
申请号：US12437482
申请日：2009-05-07
CPC分类号： A61F9/00781 , A61F9/0017 , A61F9/007 , A61F2009/00891 , A61F2250/0067 , A61K9/0051 , A61M27/002 , A61M2210/0612 , Y10S623/905
摘要： Surgical methods and related medical devices for treating ocular disorders are disclosed. Some methods relate to delivering an implant within an eye, and involve providing an elongate guide device, such as, a flexible guide member or a guide wire. A distal end of the guide device can be advanced into an anterior chamber of an eye, or through at least a portion of a site of resistance along a physiologic outflow pathway of the eye, or from an anterior chamber of the eye to a location proximate a physiologic outflow pathway of the eye. The implant is advanced along the guide device toward the guide device distal end, and is positioned to conduct aqueous humor between the anterior chamber and the physiologic outflow pathway.
摘要翻译： 公开了用于治疗眼部疾病的手术方法和相关的医疗装置。 一些方法涉及在眼睛内递送植入物，并且涉及提供细长的引导装置，例如柔性引导构件或导丝。 引导装置的远端可以进入眼睛的前房，或者沿着眼睛的生理流出路径，或者从眼睛的前房到位于邻近的位置的至少一部分电阻位置 眼睛的生理流出道。 植入物沿着引导装置前进到引导装置远端，并且被定位成在前房和生理流出路径之间引导房水。
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公开(公告)号：US20110105987A1
公开(公告)日：2011-05-05
申请号：US12914940
申请日：2010-10-28
IPC分类号： A61M1/00
CPC分类号： A61F9/00781 , A61F9/0017 , A61F9/007 , A61F2009/00891 , A61F2250/0067 , A61K9/0051 , A61M27/002 , A61M2210/0612 , Y10S623/905
摘要： Surgical methods and related medical devices for treating ocular disorders are disclosed. Some methods relate to delivering an implant within an eye, and involve providing an elongate guide device, such as, a flexible guide member or a guide wire. A distal end of the guide device can be advanced into an anterior chamber of an eye, or through at least a portion of a site of resistance along a physiologic outflow pathway of the eye, or from an anterior chamber of the eye to a location proximate a physiologic outflow pathway of the eye. The implant is advanced along the guide device toward the guide device distal end, and is positioned to conduct aqueous humor between the anterior chamber and the physiologic outflow pathway.
摘要翻译： 公开了用于治疗眼部疾病的手术方法和相关的医疗装置。 一些方法涉及在眼睛内递送植入物，并且涉及提供细长的引导装置，例如柔性引导构件或导丝。 引导装置的远端可以进入眼睛的前房，或者沿着眼睛的生理流出路径，或者从眼睛的前房到位于邻近的位置的至少一部分电阻位置 眼睛的生理流出道。 植入物沿着引导装置前进到引导装置远端，并且被定位成在前房和生理流出路径之间引导房水。
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公开(公告)号：US20100234790A1
公开(公告)日：2010-09-16
申请号：US12772889
申请日：2010-05-03
申请人： Hosheng Tu , Barbara Niksch , David Haffner , Gregory Smedley , Olav B. Bergheim , Morteza (Mory) Gharib
发明人： Hosheng Tu , Barbara Niksch , David Haffner , Gregory Smedley , Olav B. Bergheim , Morteza (Mory) Gharib
IPC分类号： A61M1/00
CPC分类号： A61F9/00781 , A61F9/0017 , A61F2250/0067 , A61L27/54 , A61L2300/258 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/42 , A61L2430/16 , A61M27/002
摘要： Implants and methods for treating ocular disorders are provided. One method involves introducing an implant into an anterior chamber of an eye such that at least a distal end of the implant is temporarily in the anterior chamber. The implant is implanted into eye tissue adjacent the anterior chamber. A therapeutic agent is eluted from the implant into at least one of the anterior chamber, a physiologic outflow pathway of the eye, and a space adjacent a choroid of the eye. The therapeutic agent can be an antiproliferative agent, an anti-inflammatory drug, or a compound for treating glaucoma or ocular hypertension. The therapeutic agent can be contained within the implant or coated on the implant.
摘要翻译： 提供了用于治疗眼部疾病的植入物和方法。 一种方法包括将植入物引入眼睛的前房，使得植入物的至少远端暂时位于前房中。 将植入物植入邻近前房的眼组织。 将治疗剂从植入物洗脱到前房中的至少一个，眼睛的生理流出路径和与眼睛的脉络膜相邻的空间。 治疗剂可以是抗增生剂，抗炎药或治疗青光眼或高眼压症的化合物。 治疗剂可以包含在植入物内或涂覆在植入物上。
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9.发明申请公开(公告)号：US20090137983A1
公开(公告)日：2009-05-28
申请号：US12366242
申请日：2009-02-05
IPC分类号： A61F9/007
CPC分类号： A61F9/00781 , A61F9/0017 , A61F9/007 , A61F2009/00891 , A61F2250/0067 , A61K9/0051 , A61M27/002 , A61M2210/0612 , Y10S623/905
摘要： Implants and methods for treating ocular disorders are described. One method involves providing an elongated delivery device and an implant mounted at a distal end of the delivery device. An incision is formed in eye tissue and the implant is inserted the through the incision using the delivery device. The implant is implanted at a location communicating with a physiologic outflow pathway of an eye such that a distal end portion of the implant and a proximal end portion of the delivery device are relatively disposed in a non-linear orientation during implantation. In one method, the implant is non-linear after insertion.
摘要翻译： 描述了用于治疗眼部疾病的植入物和方法。 一种方法包括提供细长的输送装置和安装在输送装置的远端处的植入物。 在眼组织中形成切口，并且使用输送装置将植入物插入穿过切口。 将植入物植入在与眼睛的生理流出道相通的位置处，使得植入物的远端部分和输送装置的近端部分在植入期间以非线性取向相对地布置。 在一种方法中，植入物在插入后是非线性的。
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公开(公告)号：US08273050B2
公开(公告)日：2012-09-25
申请号：US10889254
申请日：2004-07-12
CPC分类号： A61F9/00781 , A61F9/0017 , A61F9/007 , A61F2009/00891 , A61F2250/0067 , A61K9/0051 , A61M27/002 , A61M2210/0612 , Y10S623/905
摘要： Ocular implants and methods of treating ocular disorders are provided. One method involves inserting an implant into an anterior chamber of an eye. The implant has a therapeutic drug or agent and is advanced within the anterior chamber to a location posterior to a cornea of the eye. At least a portion of the implant is placed into eye tissue at this location. The therapeutic drug of the implant is exposed to aqueous humor. In one method, an anchor is utilized to retain the implant in eye tissue.
摘要翻译： 提供眼部植入物和治疗眼部疾病的方法。 一种方法是将植入物插入眼睛的前房。 植入物具有治疗药物或药剂，并且在前房内前进到眼睛角膜后面的位置。 将植入物的至少一部分放置在眼部组织中。 植入物的治疗药物暴露于房水中。 在一种方法中，使用锚固体将植入物保持在眼睛组织中。
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