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公开(公告)号:US20100234790A1
公开(公告)日:2010-09-16
申请号:US12772889
申请日:2010-05-03
申请人: Hosheng Tu , Barbara Niksch , David Haffner , Gregory Smedley , Olav B. Bergheim , Morteza (Mory) Gharib
发明人: Hosheng Tu , Barbara Niksch , David Haffner , Gregory Smedley , Olav B. Bergheim , Morteza (Mory) Gharib
IPC分类号: A61M1/00
CPC分类号: A61F9/00781 , A61F9/0017 , A61F2250/0067 , A61L27/54 , A61L2300/258 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/42 , A61L2430/16 , A61M27/002
摘要: Implants and methods for treating ocular disorders are provided. One method involves introducing an implant into an anterior chamber of an eye such that at least a distal end of the implant is temporarily in the anterior chamber. The implant is implanted into eye tissue adjacent the anterior chamber. A therapeutic agent is eluted from the implant into at least one of the anterior chamber, a physiologic outflow pathway of the eye, and a space adjacent a choroid of the eye. The therapeutic agent can be an antiproliferative agent, an anti-inflammatory drug, or a compound for treating glaucoma or ocular hypertension. The therapeutic agent can be contained within the implant or coated on the implant.
摘要翻译: 提供了用于治疗眼部疾病的植入物和方法。 一种方法包括将植入物引入眼睛的前房,使得植入物的至少远端暂时位于前房中。 将植入物植入邻近前房的眼组织。 将治疗剂从植入物洗脱到前房中的至少一个,眼睛的生理流出路径和与眼睛的脉络膜相邻的空间。 治疗剂可以是抗增生剂,抗炎药或治疗青光眼或高眼压症的化合物。 治疗剂可以包含在植入物内或涂覆在植入物上。
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公开(公告)号:US07708711B2
公开(公告)日:2010-05-04
申请号:US10706300
申请日:2003-11-12
申请人: Hosheng Tu , Barbara Niksch , David Haffner , Gregory Smedley , Olav B. Bergheim , Morteza (Mory) Gharib
发明人: Hosheng Tu , Barbara Niksch , David Haffner , Gregory Smedley , Olav B. Bergheim , Morteza (Mory) Gharib
IPC分类号: A61M19/00
CPC分类号: A61F9/00781 , A61F9/0017 , A61F2250/0067 , A61L27/54 , A61L2300/258 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/42 , A61L2430/16 , A61M27/002
摘要: Devices and methods are provided for the treatment of ocular disorders. An ocular implant has a body comprising material that includes a therapeutic drug. The body has an inlet portion and an outlet portion. The inlet portion is configured to reside in an anterior chamber of an eye when the outlet portion is disposed in a physiological outflow pathway of the eye. The outlet portion has an outflow opening such that the body drains fluid from the anterior chamber to the physiological outflow pathway. One method of treating an ocular disorder involves introducing an implant comprising a therapeutic drug into the eye such that the implant drains aqueous humor into a physiological outflow pathway and the therapeutic drug reaches eye tissue.
摘要翻译: 提供了用于治疗眼部疾病的装置和方法。 眼部植入物具有包含治疗药物的材料的主体。 主体具有入口部分和出口部分。 当出口部分设置在眼睛的生理流出路径中时,入口部分构造成位于眼睛的前房中。 出口部分具有流出开口,使得主体将流体从前房排出到生理流出路径。 治疗眼部疾病的一种方法包括将包含治疗药物的植入物引入眼睛,使得植入物将房水排入生理流出途径,并且治疗药物到达眼组织。
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公开(公告)号:US08348877B2
公开(公告)日:2013-01-08
申请号:US12772889
申请日:2010-05-03
申请人: Hosheng Tu , Barbara Niksch , David Haffner , Gregory Smedley , Olav B Bergheim , Morteza Gharib
发明人: Hosheng Tu , Barbara Niksch , David Haffner , Gregory Smedley , Olav B Bergheim , Morteza Gharib
IPC分类号: A61M19/00
CPC分类号: A61F9/00781 , A61F9/0017 , A61F2250/0067 , A61L27/54 , A61L2300/258 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/42 , A61L2430/16 , A61M27/002
摘要: Implants and methods for treating ocular disorders are provided. One method involves introducing an implant into an anterior chamber of an eye such that at least a distal end of the implant is temporarily in the anterior chamber. The implant is implanted into eye tissue adjacent the anterior chamber. A therapeutic agent is eluted from the implant into at least one of the anterior chamber, a physiologic outflow pathway of the eye, and a space adjacent a choroid of the eye. The therapeutic agent can be an antiproliferative agent, an anti-inflammatory drug, or a compound for treating glaucoma or ocular hypertension. The therapeutic agent can be contained within the implant or coated on the implant.
摘要翻译: 提供了用于治疗眼部疾病的植入物和方法。 一种方法包括将植入物引入眼睛的前房,使得植入物的至少远端暂时位于前房中。 将植入物植入邻近前房的眼组织。 将治疗剂从植入物洗脱到前房中的至少一个,眼睛的生理流出路径和与眼睛的脉络膜相邻的空间。 治疗剂可以是抗增生剂,抗炎药或治疗青光眼或高眼压症的化合物。 治疗剂可以包含在植入物内或涂覆在植入物上。
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公开(公告)号:US20080015488A1
公开(公告)日:2008-01-17
申请号:US11860785
申请日:2007-09-25
申请人: Hosheng Tu , Gregory Smedley , Barbara Niksch , David Haffner
发明人: Hosheng Tu , Gregory Smedley , Barbara Niksch , David Haffner
IPC分类号: A61M1/00
CPC分类号: A61F2/16 , A61F9/00781 , A61K9/0048
摘要: The invention relates generally medical devices and methods for the treatment of glaucoma in an animal eye and, more particularly, to medical devices and methods for treating tissue of the trabecular meshwork and/or Schlemm's canal of the eye to restore or rejuvenate a portion or all of the normal physiological function of directing aqueous outflow for maintaining a normal intraocular pressure in the eye.
摘要翻译: 本发明一般涉及用于治疗动物眼睛中的青光眼的医疗装置和方法,更具体地,涉及用于治疗小梁网和/或眼睛的施莱姆氏管的组织以恢复或恢复一部分或全部的医疗装置和方法 引导水流出的正常生理功能,以维持眼中正常的眼内压。
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公开(公告)号:US20070118147A1
公开(公告)日:2007-05-24
申请号:US11653815
申请日:2007-01-16
申请人: Gregory Smedley , David Haffner , Barbara Niksch , Hosheng Tu , Thomas Burns
发明人: Gregory Smedley , David Haffner , Barbara Niksch , Hosheng Tu , Thomas Burns
IPC分类号: A61F9/00
CPC分类号: A61F9/00781 , A61F9/0017 , A61F9/00736 , A61F9/00754
摘要: A method is provided for treatment of cataract in combination with a glaucoma procedure while maintaining the intraocular pressure by permitting aqueous to flow out of an anterior chamber of the eye through a surgically stented pathway. A trabecular stent is adapted for implantation within the trabecular meshwork of an eye such that intraocular liquid flows controllably from the anterior chamber of the eye to Schlemm's canal, bypassing the trabecular meshwork. Depending upon the specific treatment contemplated, pharmaceuticals may be utilized in conjunction with the trabecular stent enabling post-cataract healing processes.
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公开(公告)号:US20060047263A1
公开(公告)日:2006-03-02
申请号:US11255625
申请日:2005-10-21
申请人: Hosheng Tu , Gregory Smedley , Barbara Niksch , David Haffner
发明人: Hosheng Tu , Gregory Smedley , Barbara Niksch , David Haffner
IPC分类号: A61M31/00
CPC分类号: A61F2/16 , A61F9/00781 , A61K9/0048
摘要: The invention relates generally medical devices and methods for the treatment of glaucoma in an animal eye and, more particularly, to medical devices and methods for treating tissue of the trabecular meshwork and/or Schlemm's canal of the eye to restore or rejuvenate a portion or all of the normal physiological function of directing aqueous outflow for maintaining a normal intraocular pressure in the eye.
摘要翻译: 本发明一般涉及用于治疗动物眼睛中的青光眼的医疗装置和方法,更具体地,涉及用于治疗小梁网和/或眼睛的施莱姆氏管的组织以恢复或恢复一部分或全部的医疗装置和方法 引导水流出的正常生理功能,以维持眼中正常的眼内压。
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公开(公告)号:US20070112292A1
公开(公告)日:2007-05-17
申请号:US11598542
申请日:2006-11-13
申请人: Hosheng Tu , Gregory Smedley , David Haffner , Barbara Niksch
发明人: Hosheng Tu , Gregory Smedley , David Haffner , Barbara Niksch
IPC分类号: A61M5/00
CPC分类号: A61M27/00 , A61F9/00781
摘要: The invention relates generally to medical devices and methods for reducing the intraocular pressure in an animal eye and, more particularly, to stent type devices for permitting aqueous outflow from the eye's anterior chamber and associated methods thereof for the treatment of glaucoma. Some aspects provide a self-trephining glaucoma stent and methods thereof which advantageously allow for a “one-step” procedure in which the incision and placement of the stent are accomplished by a single device and operation. This desirably allows for a faster, safer, and less expensive surgical procedure.
摘要翻译: 本发明一般涉及用于降低动物眼睛中的眼内压的医疗装置和方法,更具体地,涉及用于允许水眼从前房的水流出及其相关方法用于治疗青光眼的支架型装置。 一些方面提供了自交叉青光眼支架及其方法,其有利地允许通过单个装置和操作实现支架的切口和放置的“一步”程序。 这理想地允许更快,更安全和更便宜的外科手术。
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公开(公告)号:US20070010827A1
公开(公告)日:2007-01-11
申请号:US11455391
申请日:2006-06-19
申请人: Hosheng Tu , David Haffner , Gregory Smedley , Barbara Niksch , Morteza Gharib
发明人: Hosheng Tu , David Haffner , Gregory Smedley , Barbara Niksch , Morteza Gharib
IPC分类号: A61F11/00
CPC分类号: A61F9/00781 , A61M27/002
摘要: Surgical methods and related medical devices for treating glaucoma are disclosed. The method comprises trabecular bypass surgery, which involves bypassing diseased trabecular meshwork with the use of a stent implant. The stent implant is inserted into an opening created in the trabecular meshwork by a piercing member that is slidably advanceable through the lumen of the stent implant for supporting the implant insertion. The stent implant is positioned through the trabecular meshwork so that an inlet end of the stent implant is exposed to the anterior chamber of the eye and an outlet end is positioned into fluid collection channels at about an exterior surface of the trabecular meshwork or up to the level of aqueous veins.
摘要翻译: 公开了用于治疗青光眼的手术方法和相关的医疗装置。 该方法包括小梁旁路手术,其涉及利用支架植入物绕过患病的小梁网。 支架植入物通过刺穿构件插入在小梁网中形成的开口中,该刺穿构件可滑动地前进通过支架植入物的内腔,用于支撑植入物插入。 支架植入物定位穿过小梁网,使得支架植入物的入口端暴露于眼睛的前房,并且出口端被定位在围绕小梁网的外表面的流体收集通道中,或直到 水静脉水平。
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公开(公告)号:US20060241749A1
公开(公告)日:2006-10-26
申请号:US11455598
申请日:2006-06-19
申请人: Hosheng Tu , David Haffner , Gregory Smedley , Barbara Niksch , Morteza Gharib
发明人: Hosheng Tu , David Haffner , Gregory Smedley , Barbara Niksch , Morteza Gharib
IPC分类号: A61F2/14
CPC分类号: A61F9/00781 , A61M27/002
摘要: Surgical methods and related medical devices for treating glaucoma are disclosed. The method comprises trabecular bypass surgery, which involves bypassing diseased trabecular meshwork with the use of a stent implant. The stent implant is inserted into an opening created in the trabecular meshwork by a piercing member that is slidably advanceable through the lumen of the stent implant for supporting the implant insertion. The stent implant is positioned through the trabecular meshwork so that an inlet end of the stent implant is exposed to the anterior chamber of the eye and an outlet end is positioned into fluid collection channels at about an exterior surface of the trabecular meshwork or up to the level of aqueous veins.
摘要翻译: 公开了用于治疗青光眼的手术方法和相关的医疗装置。 该方法包括小梁旁路手术,其涉及利用支架植入物绕过患病的小梁网。 支架植入物通过刺穿构件插入在小梁网中形成的开口中,该刺穿构件可滑动地前进通过支架植入物的内腔,用于支撑植入物插入。 支架植入物定位穿过小梁网,使得支架植入物的入口端暴露于眼睛的前房,并且出口端被定位在围绕小梁网的外表面的流体收集通道中,或直到 水静脉水平。
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公开(公告)号:US20070276316A1
公开(公告)日:2007-11-29
申请号:US11836112
申请日:2007-08-08
申请人: David Haffner , Gregory Smedley , Hosheng Tu
发明人: David Haffner , Gregory Smedley , Hosheng Tu
IPC分类号: A61M1/00
CPC分类号: A61F9/00781
摘要: Intraocular stents and applicators are disclosed for treating glaucoma. The stents are configured to extend between the anterior chamber of the eye and Schlemm's canal for enhancing outflow of aqueous from the anterior chamber so as to reduce intraocular pressure. The stents can have features for anchoring the stent into Schlemm's canal as well as preventing the walls of Schlemm's canal from closing the outlet of the stents. The applicators can be steerable so as to make implantation easier. Additionally, the applicators can be configured to hold a plurality of stents so that multiple stents can be implanted through one incision without removing the applicator from the incision between serial implantations.
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