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公开(公告)号：US20110306548A1
公开(公告)日：2011-12-15
申请号：US13144757
申请日：2010-01-22
申请人： Ole Hvilsted Olsen , Jens Breinholt , Christine Bruun Schiødt , Helle Demuth , Leif Nørskov-Lauritsen , Peter Thygesen
发明人： Ole Hvilsted Olsen , Jens Breinholt , Christine Bruun Schiødt , Helle Demuth , Leif Nørskov-Lauritsen , Peter Thygesen
摘要： The present invention relates to stable growth hormone (GH) compounds, which through the introduction of cysteine residues have disulphide bridges, which make the compounds resistant to proteolytic degradation.
摘要翻译： 本发明涉及稳定生长激素（GH）化合物，其通过引入半胱氨酸残基具有二硫键，这使得化合物对蛋白水解降解具有抗性。
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公开(公告)号：US08513192B2
公开(公告)日：2013-08-20
申请号：US13144757
申请日：2010-01-22
申请人： Ole Hvilsted Olsen , Jens Breinholt , Christine Bruun Schiødt , Helle Demuth , Leif Nørskov-Lauritsen , Peter Thygesen
发明人： Ole Hvilsted Olsen , Jens Breinholt , Christine Bruun Schiødt , Helle Demuth , Leif Nørskov-Lauritsen , Peter Thygesen
摘要： The present invention relates to stable growth hormone (GH) compounds, which through the introduction of cysteine residues have disulphide bridges, which make the compounds resistant to proteolytic degradation.
摘要翻译： 本发明涉及稳定生长激素（GH）化合物，其通过引入半胱氨酸残基具有二硫键，这使得化合物对蛋白水解降解具有抗性。
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3.发明授权Furyl-pyridone compounds, useful as fungicides and obtained from the fungus Cladobotryum 失效呋喃基 - 吡啶酮化合物，可用作杀真菌剂并从真菌Cladobotryum得到公开(公告)号：US06172006B2
公开(公告)日：2001-01-09
申请号：US09040488
申请日：1998-03-18
IPC分类号： A01N4340
CPC分类号： C07D491/04 , A01N43/90 , A01N63/04 , C12P17/18 , C12R1/645 , Y10S435/911
摘要： The invention relates to biologically active novel compounds having formula (I) as defined herein. Also disclosed are methods of preparing said compounds, fungicidal compositions comprising, as an active ingredient, these compounds, use of the compounds, and method of controlling fungi at loci infested or liable to be infested therewith.
摘要翻译： 本发明涉及具有本文定义的式（I）的生物活性新型化合物。 还公开了制备所述化合物的方法，杀真菌组合物包含作为活性成分的这些化合物，该化合物的用途，以及控制真菌侵袭或易于侵染的位点的方法。
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公开(公告)号：US20130143815A1
公开(公告)日：2013-06-06
申请号：US13809681
申请日：2011-07-15
申请人： Henrik Sune Andersen , Kjeld Madsen , Helle Demuth , Christine Bruun Schioedt , Leif Noerskov-Lauritsen , Peter Thygesen , Carsten Behrens , Mette Guldbrandt
发明人： Henrik Sune Andersen , Kjeld Madsen , Helle Demuth , Christine Bruun Schioedt , Leif Noerskov-Lauritsen , Peter Thygesen , Carsten Behrens , Mette Guldbrandt
IPC分类号： C07K14/61
CPC分类号： C07K14/61 , A61K47/554
摘要： The present invention relates to growth hormone conjugates comprising a bile acid residue, said conjugation may occur through wt or mutant amino acid residues. The growth hormone polypeptide may be wt human growth hormone or a growth hormone variant.
摘要翻译： 本发明涉及包含胆汁酸残基的生长激素缀合物，所述缀合可以通过wt或突变体氨基酸残基进行。 生长激素多肽可以是人生长激素或生长激素变体。
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公开(公告)号：US09211342B2
公开(公告)日：2015-12-15
申请号：US13574128
申请日：2011-01-24
申请人： Helle Demuth , Christine Brunn Schioedt , Leif Noerskov-Lauritsen , Jianhe Chen , Peter Thygesen
发明人： Helle Demuth , Christine Brunn Schioedt , Leif Noerskov-Lauritsen , Jianhe Chen , Peter Thygesen
CPC分类号： A61K47/48215 , A61K38/00 , A61K47/60 , C07K14/61
摘要： The present invention relates to growth hormone (GH) compounds having additional disulphide bridges and at least one additional single point mutation making the compounds resistant to proteolytic degradation.
摘要翻译： 本发明涉及具有额外二硫键的生长激素（GH）化合物和至少一种额外的单点突变，使得化合物对蛋白水解降解具有抗性。
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公开(公告)号：US20130040883A1
公开(公告)日：2013-02-14
申请号：US13574128
申请日：2011-01-24
申请人： Helle Demuth , Christine Brunn Schioedt , Leif Noerskov-Lauritsen , Jianhe Chen , Peter Thygesen
发明人： Helle Demuth , Christine Brunn Schioedt , Leif Noerskov-Lauritsen , Jianhe Chen , Peter Thygesen
CPC分类号： A61K47/48215 , A61K38/00 , A61K47/60 , C07K14/61
摘要： The present invention relates to growth hormone (GH) compounds having additional disulphide bridges and at least one additional single point mutation making the compounds resistant to proteolytic degradation.
摘要翻译： 本发明涉及具有额外二硫键的生长激素（GH）化合物和至少一种额外的单点突变，使得化合物对蛋白水解降解具有抗性。
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![4,5,6,7-tetrahydro-thieno[3, 2-C]pyridine derivatives, their preparation and use](/abs-image/US/2001/01/23/US06177443B1/abs.jpg.150x150.jpg)
7.发明授权4,5,6,7-tetrahydro-thieno[3, 2-C]pyridine derivatives, their preparation and use 失效4,5,6,7-四氢 - 噻吩并[3,2-C]吡啶衍生物，其制备和用途公开(公告)号：US06177443B1
公开(公告)日：2001-01-23
申请号：US09035464
申请日：1998-03-05
申请人： Peter Madsen , Jane Marie Lundbeck , Niels Westergarrd , Lars Naerum , Annemarie Reinhardt Varming , Helle Demuth , Morten Heide
发明人： Peter Madsen , Jane Marie Lundbeck , Niels Westergarrd , Lars Naerum , Annemarie Reinhardt Varming , Helle Demuth , Morten Heide
IPC分类号： A61K3144
CPC分类号： A61K31/4365 , A61K31/44 , A61K31/47
摘要： The present invention relates to pharmaceutical compositions comprising a pharmaceutically acceptable carrier or diluent and a compound of formula I wherein A together with the double bond of formula I is benzene or thiophene; R1 is optionally substituted C1-6 alkyl or optionally substituted aryl; R2 is optionally substituted C1-6-alkyl, optionally substituted aralkyl, or —COR3, wherein R3 is optionally substituted C1-6-alkyl, optionally substituted aralkyl, or optionally substituted aryl; R4 and R5 independently are hydrogen, halogen, perhalomethyl, optionally substituted C1-6-alkyl, hydroxy, optionally substituted C1-6-alkoxy, nitro, cyano, amino, optionally substituted mono- or optionally substituted di-C1-6-alkylamino, acylamino, C1-6-alkoxycarbonyl, carboxy or carbamoyl; n is 0, and m is 1, and methods of treating or preventing a disease of the endocrinologic system.
摘要翻译： 本发明涉及包含药学上可接受的载体或稀释剂和式I化合物的药物组合物，其中A与式I的双键是苯或噻吩; R1是任选取代的C 1-6烷基或任选取代的芳基; R 2是任选取代的C 1-6 - 烷基，任选取代的芳烷基或-COR 3，其中R 3是任选取代的C 1-6 - 烷基，任选取代的芳烷基或任选取代的芳基; R 4和R 5独立地是氢，卤素，全卤甲基，任选取代的C 1-6 - 烷基，羟基，任选取代的C 1-6 - 烷氧基，硝基，氰基，氨基，任选取代的单 - 或任选取代的二-C 1-6烷基氨基， 酰基氨基，C 1-6 - 烷氧基羰基，羧基或氨基甲酰基; n为0，m为1，以及治疗或预防内分泌系统疾病的方法。
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